4',6'-DIMETHOXY-2'-HYDROXYCHALCONE

CAS No.: 1775-97-9

Chemical Name:: 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE

Synonyms: FlavoringB;Flavokavin B;FLAVOKAWIN B;FLAVOKAWAIN B;Flavokavain B;FLAVOKAVAIN B(P);CARDAMONIN-4'-METHYL ETHER;4',6'-DIMETHOXY-2'-HYDROXYCHALCONE;2'-Hydroxy-4',6'-Dimethoxychalcone;4',6'-DIMETHOXY-2'-HYDROXYCHALCONE

CBNumber:: CB4430922

Molecular Formula:: C17H16O4

Molecular Weight:: 284.31

MOL File:: 1775-97-9.mol

MSDS File:: SDS

Modify Date:: 2023/5/25 18:01:09

Request For Quotation

4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Properties

Melting point	85-87°C
Boiling point	500.1±50.0 °C(Predicted)
Density	1.203±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	6.84±0.40(Predicted)
form	Solid
color	Yellow to Dark Yellow
LogP	4.206 (est)
CAS DataBase Reference	1775-97-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Chemical Properties,Uses,Production

Description

Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC₅₀s = 32, 48, 6.2, and 3.9 μM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD₅₀s = 15 and 32 μM, respectively).

Uses

Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models. ?Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.

4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

5,7-DIMETHOXYFLAVONE

4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Suppliers

Global( 138)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Biosyn Research Chemicals	+91-91-9346022300 +91-9346022300	Telangana, India	465	58	Inquiry
chromsynth pvt ltd	+919704220374	Hyderabad, India	244	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Biosyn Research Chemicals	+91 9346022300/+91 9399339999	Telangana, India	1340	58	Inquiry
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	CHINA	1824	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3777	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	China	11506	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry

Supplier	Advantage
Biosyn Research Chemicals	58
chromsynth pvt ltd	58
CLEARSYNTH LABS LTD.	58
Biosyn Research Chemicals	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
career henan chemical co	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hubei Ipure Biology Co., Ltd	58

1775-97-9(4',6'-DIMETHOXY-2'-HYDROXYCHALCONE)Related Search:

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5,7-DIMETHOXYFLAVONE 3',4',5',5,6,7-HEXAMETHOXYFLAVONE 2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE 3',4',5',5,7-PENTAMETHOXYFLAVONE 5,6,7-TRIMETHOXYFLAVONE

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2'-Hydroxychalcone CARDAMONIN 4',5,7-TRIMETHOXYFLAVONE

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CARDAMONIN-4'-METHYL ETHER FLAVOKAWAIN B FLAVOKAWIN B DIMETHOXY-2'-HYDROXYCHALCONE, 4',6'- (E)-1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPENONE 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one) (E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl- FLAVOKAVAIN B(P) Flavokavin B (E)-2'-Hydroxy-4',6'-dimethoxychalcone Flavokavain B (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one FlavoringB 4',6'-Dimethoxy-2'-hydroxychalcone (Flavokawain B) 2-Propen-1-one,1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)- 2'-Hydroxy-4',6'-Dimethoxychalcone (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 1775-97-9 Chalcones Plant Oils, Toxins, Phenolic Acids & Derivatives