2-Hydroxychalcone
- CAS No.
- 644-78-0
- Chemical Name:
- 2-Hydroxychalcone
- Synonyms
- 2-HYDROXYCHALCONE;o-Hydroxychalcone;2-HYDROXYCHALCONE;HYDROXYCHALCONE, 2-;2-Hydroxychalcone>SALICYLALACETOPHENONE;HYDROXYCHALCONE,2-(AS);2-Hydroxychalcone, 98+%;TRANS-2-HYDROXYCHALCONE;2-(2-HYDROXYBENZAL)ACETOPHENONE
- CBNumber:
- CB7100356
- Molecular Formula:
- C15H12O2
- Molecular Weight:
- 224.25
- MOL File:
- 644-78-0.mol
- Modify Date:
- 2024/11/15 19:19:13
| Melting point | 144-150 °C(lit.) |
|---|---|
| Boiling point | 396.3±34.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| pka | 9.26±0.35(Predicted) |
| form | powder |
| color | Yellow |
| BRN | 2049134 |
| CAS DataBase Reference | 644-78-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29147000 | |||||||||
| NFPA 704 |
|
2-Hydroxychalcone price More Price(2)
2-Hydroxychalcone Chemical Properties,Uses,Production
Description
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. It is also capable of inducing apoptosis by downregulating Bcl-2 levels and inhibiting the activation of NF-kB.
in vitro
2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.
References
[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. DOI:10.1016/j.cbi.2013.03.012
[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. DOI:10.1124/MOL.58.3.526
[3]. Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity doi: 10.3390/antibiotics9090576
2-Hydroxychalcone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4535 | 58 | Inquiry |
| Anji Biosciences | +91 40 40154989 | Hyderabad, India | 201 | 58 | Inquiry |
| Discovery Intermediates Private Limited | +91 40-2305-8175 | Hyderabad, India | 19 | 58 | Inquiry |
| Discovery Intermediates Pvt., Ltd | 91-40-23058175 | Hyderabad, India | 50 | 58 | Inquiry |
| Rowan Fine Chemicals | 09849376734 | Hyderabad, India | 117 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| PEE ESS AROMATICS | +91 4426247322 | New Delhi, India | 258 | 30 | Inquiry |
| Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
| SREE SYNERIC LAB | null | New Delhi, India | 328 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Anji Biosciences | 58 |
| Discovery Intermediates Private Limited | 58 |
| Discovery Intermediates Pvt., Ltd | 58 |
| Rowan Fine Chemicals | 58 |
| CHEMSWORTH | 30 |
| Alfa Aesar | 58 |
| PEE ESS AROMATICS | 30 |
| Biosyn Research Chemicals | 58 |
| SREE SYNERIC LAB | 58 |
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