Naphthol AS-E
- CAS No.
- 92-78-4
- Chemical Name:
- Naphthol AS-E
- Synonyms
- nAS-E;C.I. 37510;Naftol AS-E;NAPTHOL AS-E;NAPHTHOL AS-E;Amarthol AS-E;DaitoGrounderE;AcnaNaphtholPC;Kiwa Grounder E;92-78-4 Naphthol AS-E
- CBNumber:
- CB4723659
- Molecular Formula:
- C17H12ClNO2
- Molecular Weight:
- 297.74
- MOL File:
- 92-78-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 17:06:35
Melting point | 255°C |
---|---|
Boiling point | 416.5±30.0 °C(Predicted) |
Density | 1.399±0.06 g/cm3(Predicted) |
vapor pressure | 0Pa at 25℃ |
storage temp. | Sealed in dry,Room Temperature |
solubility | soluble in Dimethylformamide |
pka | 8.69±0.40(Predicted) |
Colour Index | 37510 |
form | Beige solid |
color | White to Light yellow to Dark green |
LogP | 2.97 at 23℃ and pH7.2 |
CAS DataBase Reference | 92-78-4(CAS DataBase Reference) |
EPA Substance Registry System | 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-hydroxy- (92-78-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H317-H319 |
Precautionary statements | P261-P264-P272-P280-P302+P352-P305+P351+P338 |
HS Code | 2924.29.7790 |
Naphthol AS-E price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 217505 | CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB. | 92-78-4 | 250MG | ₹10709.99 | 2022-06-14 | Buy |
TCI Chemicals (India) | C2103 | 4'-Chloro-3-hydroxy-2-naphthanilide | 92-78-4 | 25G | ₹5000 | 2022-05-26 | Buy |
Naphthol AS-E Chemical Properties,Uses,Production
Preparation
4-Chlorobenzenamine and 3-Hydroxy-2-naphthoic acid condensation.
General Description
A cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 M, respectively) by directly binding to CBP′s KIX domain (Kd ~8.6 M using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin in a HEK293T-based RLuc reporter assay (IC50<2.5 M), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 M), but not that of RLuc.
Properties and Applications
light yellow microstrip red uniform powder, melting point for 258 ~ 259 ℃. Insoluble in water solution and sodium carbonate, soluble in adjacent two chlorobenzene, ethanol and glacial acetic acid. Sodium hydroxide solution for yellow in the liquid. Sensitive to air. Mainly used for cotton fabrics, viscose and silk dyeing, general is not used for printing, and can be used as organic pigments intermediate. This product to cotton affinity is higher, coupled ability medium.
Naphthol AS-E Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Bhagwati Industries | +91-9909249884 +91-9909249884 | Gujarat, India | 89 | 58 | Inquiry |
Jagson Colorchem Limited | +91-9879484214 +91-9879484214 | Gujarat, India | 318 | 58 | Inquiry |
Vipul Organics Ltd | +91-2266139999 +91-2266139999 | Maharashtra, India | 277 | 58 | Inquiry |
Jaffs Dyechem Private Limited | +91-9825035135 +91-7925392314 | Gujarat, India | 309 | 58 | Inquiry |
Aarnee International | 91-79-40055406 | Gujarat, India | 20 | 58 | Inquiry |
Textile Colour and Chemical (Exports) | 91-79-26575821 | Gujarat, India | 38 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Emco Dyestuff Private Limited | 08048372738Ext 428 | Mumbai, India | 15 | 58 | Inquiry |
Daikaffil Chemicals (India) Limited | +91 22 2353 0325 | Maharashtra, India | 6 | 58 | Inquiry |
Om Impex | 08048371895Ext 259 | Maharashtra, India | 35 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Bhagwati Industries | 58 |
Jagson Colorchem Limited | 58 |
Vipul Organics Ltd | 58 |
Jaffs Dyechem Private Limited | 58 |
Aarnee International | 58 |
Textile Colour and Chemical (Exports) | 58 |
A.J Chemicals | 58 |
Emco Dyestuff Private Limited | 58 |
Daikaffil Chemicals (India) Limited | 58 |
Om Impex | 58 |
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