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6-hydroxydexamethasone

6-hydroxydexamethasone Structure
CAS No.
55879-47-5
Chemical Name:
6-hydroxydexamethasone
Synonyms
6-hydroxydexamethasone;6β-hydroxy Dexamethasone;Dexamethasone Impurity 12;Dexamethasone 6β-Hydroxy Impurity;Dexamethasone 6beta-Hydroxy Impurity;6-Hydroxydexamethasone Solution, 100ppm;(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CBNumber:
CB51341435
Molecular Formula:
C22H29FO6
Molecular Weight:
408.46
MOL File:
55879-47-5.mol
Modify Date:
2023/5/18 11:31:20
Request For Quotation

6-hydroxydexamethasone Properties

Melting point 259-262°C
Boiling point 613.2±55.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Dioxane (Very Slightly, Sonicated), Methanol (Slightly)
form Solid
pka 12.06±0.70(Predicted)
color White to Light Yellow

6-hydroxydexamethasone Chemical Properties,Uses,Production

Description

6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

Chemical Properties

Off-White Solid

Uses

The hydrophilic metabolite of Dexamethasone (D298800).

6-hydroxydexamethasone Preparation Products And Raw materials

Raw materials

Preparation Products

6-hydroxydexamethasone Suppliers

Global( 29)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
China National Standard Pharmaceutical Corporation Limited +8615391658522 China 11927 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd 18502726233; 18502726233 China 9820 58 Inquiry
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 China 30968 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28118 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
China National Standard Pharmaceutical Corporation Limited 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd 58
Nantong Hanfang Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

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6-hydroxydexamethasone Dexamethasone 6β-Hydroxy Impurity Dexamethasone Impurity 12 6-Hydroxydexamethasone Solution, 100ppm (6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one Dexamethasone 6beta-Hydroxy Impurity 6β-hydroxy Dexamethasone 55879-47-5 C22H29FO6 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids