Lomerizine hydrochloride
- CAS No.
- 101477-54-7
- Chemical Name:
- Lomerizine hydrochloride
- Synonyms
- KB 2796;TERRANAS;Lomeizine HCL;LOMERIZINE HCL;Lomerizine2HCl;LOMERIZINE DIHCL;KB-2796, Terranas;LOMERIZINEHYDROCHLORTDE;KB-2796 dihydrochloride;LOMERIZINE HYDROCHLORIDE
- CBNumber:
- CB5186585
- Molecular Formula:
- C27H32Cl2F2N2O3
- Molecular Weight:
- 541.46
- MOL File:
- 101477-54-7.mol
- Modify Date:
- 2023/6/8 9:03:00
| Melting point | 214-218°C dec. |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥30mg/mL |
| form | powder |
| color | white to tan |
| Merck | 14,5563 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 101477-54-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TK9189000 | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | LD50 orally in mice: 300 mg/kg (Ohtaka) | |||||||||
| NFPA 704 |
|
Lomerizine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L6295 | Lomerizine dihydrochloride ≥98% (HPLC), powder | 101477-54-7 | 10MG | ₹9601.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L6295 | Lomerizine dihydrochloride ≥98% (HPLC), powder | 101477-54-7 | 50MG | ₹38688.55 | 2022-06-14 | Buy |
| TCI Chemicals (India) | L0245 | Lomerizine Dihydrochloride | 101477-54-7 | 200MG | ₹5100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | L0245 | Lomerizine Dihydrochloride | 101477-54-7 | 1G | ₹14800 | 2022-05-26 | Buy |
Lomerizine hydrochloride Chemical Properties,Uses,Production
Description
Lomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination of mechanisms, especially a functional block of L-type voltagesensitive calcium channels (L-VSCCs). Lomerizine increases cerebral blood flow compared to peripheral blood flow with only weak effects on systemic arterial blood pressure. Other mechanisms involved could be blockade of other VSCC and sodium channels, 5-HT2 and alpha-1 receptors. As a reducing agent of cortical spreading depression and neurogenic inflammation, Lomerizine was shown to be useful in migraine. In an open clinical study, it demonstrated efficacy in the treatment of cluster headache. Moreover, it may have utility in other neurological diseases such as cerebrovascular ischemia or cerebral infarction.
Chemical Properties
Colourless Crystalline Solid
Uses
A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.
Lomerizine hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | CHINA | 1320 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 11667 | 58 | Inquiry |
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