Trimetazidine
- CAS No.
- 5011-34-7
- Chemical Name:
- Trimetazidine
- Synonyms
- Preductal;Vasorel;Vasartel;AKOS B006602;TRIMETAZIDINE;TRIMETAZIDINE HCL;TIMTEC-BB SBB007020;ART-CHEM-BB B006602;ART-CHEM-BB B014361;Trimetazidine USP/EP/BP
- CBNumber:
- CB4126777
- Molecular Formula:
- C14H22N2O3
- Molecular Weight:
- 266.34
- MOL File:
- 5011-34-7.mol
- Modify Date:
- 2024/7/18 18:48:51
| Boiling point | bp2 200-205° |
|---|---|
| Density | 1.092±0.06 g/cm3(Predicted) |
| vapor pressure | 0.003Pa at 25℃ |
| storage temp. | Hygroscopic, Refrigerator, Under inert atmosphere |
| solubility | Chlorofrom (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.07±0.10(Predicted) |
| color | Colourless to Pale Yellow Gel |
| Stability | Hygroscopic |
| LogP | 1.143 at 25℃ and pH6 |
| CAS DataBase Reference | 5011-34-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H226-H314-H412-H302 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P270-P301+P312-P330-P501-P273-P501 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
Trimetazidine Chemical Properties,Uses,Production
Originator
Vastarel,Biopharma,France,1963
Manufacturing Process
Monoformylpiperazine is reacted molecule for molecule with 2,3,4-
trimethoxybenzyl chloride in the presence of 1 1/2 molecules of sodium
carbonate and in suspension in ethyl alcohol, during 2 to 3 hours.
The reaction product is filtered and the filtrate is evaporated in vacuo to
remove the alcohol. There remains an oily product from which the excess
formyl-ethylenediamine is removed by distillation under 1 mm Hg pressure up
to 125°C. The dark yellow, residual product is treated with 10% hydrochloric
acid at 100°C for 12 hours to eliminate the formyl group; it is evaporated to a
syrupy consistency and taken up with ethyl alcohol at the boiling point until
complete miscibility is attained; it is then discolored over carbon, filtered and
stored at low temperature.
The (2,3,4-trimethoxyphenyl) methylpiperazine hydrochloride precipitates as
white needles: the precipitate is drained and washed with anhydrous sulfuric
ether. Melting point: 222°C to 226°C.
Therapeutic Function
Coronary vasodilator
Trimetazidine Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| Acute Research | +91-9825068697 +91-9825068697 | Gujarat, India | 43 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Maps Laboratories Pvt Ltd | +91-9925030826 +91-9925013085 | Gujarat, India | 28 | 58 | Inquiry |
| Rakshit Group of Companies (Rakshit Drugs Pvt Ltd) | +91-4023810385 +91-9246228579 | Telangana, India | 36 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pragati Raw Pharma Pvt Ltd | 08046071689 | Mumbai, India | 2 | 58 | Inquiry |
| Rakshit Drugs Private Limited | 09023801673 | Hyderabad, India | 21 | 58 | Inquiry |
| Bhavi Chem | 08048602333 | Mumbai, India | 73 | 58 | Inquiry |
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