ChemicalBook > Product Catalog >API >Circulatory system drugs >Angina Pectoris Drugs >Trimetazidine dihydrochloride
Trimetazidine dihydrochloride
- CAS No.
- 13171-25-0
- Chemical Name:
- Trimetazidine dihydrochloride
- Synonyms
- s4004;Takkmint;vastarel;kyurinett;Yoshimilon;Vastarel F;Youmetazine;Trimetazidine 3HCl;TRIMETAZIDINE 2HCL;TRIMETAZIDINE DI HCL
- CBNumber:
- CB6176226
- Molecular Formula:
- C14H24Cl2N2O3
- Molecular Weight:
- 339.26
- MOL File:
- 13171-25-0.mol
- Modify Date:
- 2024/7/2 8:55:13
| Melting point | 231-235 °C(lit.) |
|---|---|
| storage temp. | Refrigerator |
| solubility | Freely soluble in water, sparingly soluble in alcohol. |
| form | Solid |
| color | White to Off-White |
| Merck | 14,9705 |
| Stability | Hygroscopic |
| InChIKey | XIRALXKCBGTYSC-UHFFFAOYSA-N |
| CAS DataBase Reference | 13171-25-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TM2976100 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey) | |||||||||
| NFPA 704 |
|
Trimetazidine dihydrochloride price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 653322 | 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride 97% | 13171-25-0 | 10G | ₹11712.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 653322 | 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride 97% | 13171-25-0 | 25G | ₹20664.93 | 2022-06-14 | Buy |
Trimetazidine dihydrochloride Chemical Properties,Uses,Production
Description
Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.
Chemical Properties
Crystalline Solid
Uses
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:
- Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
- Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.
Trimetazidine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 353)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| chakrachem Lifesciences | +91 9902744663 | Hyderabad, India | 451 | 58 | Inquiry |
| Prajna generics pvt ltd | +91-9441174873 +91-9441174873 | Hyderabad, India | 24 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| JPN Pharma Pvt Ltd | +919833233531 | Maharashtra, India | 33 | 58 | Inquiry |
| Technodrugs Intermediates Pvt. Ltd. | +91-2226743405 +91-2226743405 | Maharashtra, India | 16 | 58 | Inquiry |
| Sharon Bio Medicine Ltd | +91-9769026333 +91-9821911142 | Mumbai, India | 12 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Aragen Life Sciences Pvt. Ltd. | +91-91-40-66929999 +91-914066929999 | Hyderabad, India | 18 | 58 | Inquiry |
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1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE
1-[(2,3,4-Trimethoxy-phenyl)methyl]piperazine Dihydrochloride
Vastarel F
Yoshimilon
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride,Trimetazidine dihydrochloride
Trimetazidine 3HCl
Takkmint
Youmetazine
1-[2,3,4-TRIMETHOXYPHENYL)-METHYI] PIPERAZINE DIHYDROCHLORIDE
Sibutramine trimetazidine hydrochloride
1-(2,3,4-TriMethoxybenzyl)piperazine dihydrochloride 97%
1-((2,3,4-trimethoxyphenyl)methyl)-piperazindihydrochloride
1-(2,3,4-trimethoxybenzyl)-piperazindihydrochloride
kyurinett
s4004
vastarel
1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DI&
TRIMETAZIDINE DI HCL
TRIMETAZIDINE DIHYDROCHLORIDE
TRIMETAZIDINE HYDROCHLORIDE
TRIMETAZIDINE 2HCL
1-[[2,3,4-Trimethoxyphenyl] methyl] piperazine hydrochloride
Trimetazidine for system suitability CRS
Trimetazidine dihydrochloride/TRIMETAZIDINE 2HCL
Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
Trimetazidine dihydrochloride USP/EP/BP
trimetazidine impurity1136
Trimetazidine dihydrochloride (Y0000092)
Trimetazidine DihydrochlorideQ: What is
Trimetazidine Dihydrochloride Q: What is the CAS Number of
Trimetazidine Dihydrochloride Q: What is the storage condition of
Trimetazidine Dihydrochloride Q: What are the applications of
Trimetazidine Dihydrochloride
1-(2,3,4-tetramethoxybenzyl)piperzine Di Hydrochloride
1-(2,3,4-Trimethoxybenzyl)piperazine Dihydrochloride, ≥ 98.0%
13171-25-0
C14H22N2O32HCl
C14H22N2O32HClC14H24Cl2
C14H22N2O32HClC14H24Cl2N2O3
C14H22N2O32ClH
Building Blocks
Heterocyclic Building Blocks
Piperazines
Building Blocks
C14 to C15
Chemical Synthesis
Heterocyclic Building Blocks
Piperazines
Intermediates & Fine Chemicals
Pharmaceuticals
13171-25-0