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Degarelix

CAS No.: 214766-78-6

Chemical Name:: Degarelix

Synonyms: Degarelix acetate;FirMagon;Dikarek;DEGARELIX;Degarelix-d7;Peptides Acetate;Degarelix impurity;DEGARELIX USP/EP/BP;Degarelix acetate salt;Degarelix, Degarelix acetate

CBNumber:: CB52448443

Molecular Formula:: C82H103ClN18O16

Molecular Weight:: 1632.26

MOL File:: 214766-78-6.mol

MSDS File:: SDS

Modify Date:: 2026/8/4 11:17:55

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Degarelix Properties

Density	1.325±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO:10.0(Max Conc. mg/mL);6.13(Max Conc. mM) H2O:25.0(Max Conc. mg/mL);15.32(Max Conc. mM)
pka	10.38±0.40(Predicted)
form	Solid
color	White to off-white
Sequence	Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-4-Aph(Hor)-4-D-Aph(Cbm)-Leu-Lys(ipr)-Pro-D-Ala-NH2
InChIKey	MEUCPCLKGZSHTA-XYAYPHGZSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360
Hazardous Substances Data	214766-78-6(Hazardous Substances Data)

Degarelix price

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Degarelix Chemical Properties,Uses,Production

Description

Antagonists of GnRH have proven to be an effective therapy for hormonally regulated cancers, such as prostate and some types of breast. As analogs of GnRH, they bind competitively and reversibly to GnRH receptors in the pituitary gland, thereby blocking the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In men, the reduction of LH triggers the ablation of testosterone secretion from the testes, and these castration-like levels have been essential in the effective management of advanced prostate cancer. In comparison to GnRH agonists, antagonists do not suffer from a potential flare of the disease as a result of an initial stimulation of the hypothalamic-pituitary-gonadal axis prior to down-regulation of the GnRH receptor. Moreover, GnRH antagonists provide beneficial effects more rapidly postdosing and result in a more efficient suppression of gonadotropin levels. With this in mind, degarelix acetate has been launched as a third-generation GnRH antagonist for the treatment of prostate cancer, and it joins other third-generation agents, ganirelix and cetronelix, on the market.

Uses

Degarelix, is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.

Clinical Use

Ferring launched degarelix acetate, a gonadotrophin-releasing hormone (GnRH) antagonist, in 2009 in the U.S. for the treatment of prostate cancer. The compound has been approved by the E.U. for the same indication, and in the same year it was launched in the UK and Germany. Degarelix has been developed as a one-month or three-month sustained-release injectable formulation. Compared to other GnRH antagonists, degarelix displays improved aqueous solubility, longer acting effects and weaker histamine-releasing properties.

Side effects

The most common adverse events included injection site reactions (pain, erythema, swelling, or induration), hot flashes, increased weight, and increases in serum levels of transaminases and gamma-glutamyltransferase. In addition to being contraindicated in patients with a previous hypersensitivity to degarelix, it should not be administered to women who are or may become pregnant as fetal harm can occur. Since long-term androgen deprivation therapy prolongs the QT interval, physicians should consider whether the benefits of degarelix outweigh the potential risks in patients with congenital long QT syndrome, electrolyte abnormalities, or congestive heart failure or in patients taking antiarrhythmic medications.

Degarelix Preparation Products And Raw materials

Raw materials

Preparation Products

Degarelix Suppliers

Global( 295)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jigs Chemical ltd	+919099003427	Gujarat, India	234	58	Inquiry
AKASH PHARMA EXPORTS	+91-9388123451 +91-9846039283	Kerela, India	469	58	Inquiry
AURO PEPTIDES LTD	+91 (40) 6672 1200	Beijing, India	10	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6094	58	Inquiry
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	China	15111	58	Inquiry
Apextide Co Ltd	+86-15300650552; +86-15300650552	China	91	58	Inquiry
Chengdu Shengnuo Biopharm Co.,Ltd	+86-13880038419	China	69	58	Inquiry
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	China	3370	58	Inquiry
Sichuan Hantongkuntai Biotechnology Co., LTD.	18981903347	China	235	58	Inquiry
Lotusland Life Sciences	+8615821988213	China	2411	58	Inquiry

Supplier	Advantage
Jigs Chemical ltd	58
AKASH PHARMA EXPORTS	58
AURO PEPTIDES LTD	58
CLEARSYNTH LABS LTD.	58
AFINE CHEMICALS LIMITED	58
Apextide Co Ltd	58
Chengdu Shengnuo Biopharm Co.,Ltd	58
RongNa Biotechnology Co.,Ltd	58
Sichuan Hantongkuntai Biotechnology Co., LTD.	58
Lotusland Life Sciences	58

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5,6-Dihydro-6-methyluracil N-[4-(3-Oxo-propyl)-phenyl]-acetamide N-L-phenylalanyl-L-2-amino-1-phenylpropane

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DEGARELIX N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-4-[2,6-dioxohexahydropyrimidin-4(S)-ylcarboxamido]-L-phenylalanyl-4-ureido-D-phenylalanyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide acetate D-Alaninamide, N-acetyl-3-(naphtalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-4-((((4S)-2,6-dioxohexahydropyrimidin-4-yl)carbonyl)amino)-L-phenylalanyl-4-(carbamoylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl- Degarelix acetate(FE-200486,Degarelix) Degarelix, Degarelix acetate Degarelix acetate salt D-Alaninamide,N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-ly D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl- Degarelix impurity DEGARELIX USP/EP/BP Degarelix-d7 Dikarek Peptides Acetate D7-Degarelix Trifluoroacetate FirMagon Degarelix acetate 214766-78-6 217466-78-6 C82H103ClN18O16C2H4O2 C82H103N18O16Cl C82H103ClN18O16 API