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Goserelin

CAS No.: 65807-02-5

Chemical Name:: Goserelin

Synonyms: Zoladex;Goserlin;Goserelin validation mixture CRS;Pbtbo;ici118630;Goserelin;Geserelin;Gosereline;decapeptidei;Goserelin-d7

CBNumber:: CB4281027

Molecular Formula:: C59H84N18O14

Molecular Weight:: 1269.41

MOL File:: 65807-02-5.mol

Modify Date:: 2023/11/24 16:35:22

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Goserelin Properties

Density	1.50±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	H₂O: 20 mg/mL, clear, colorless
form	white powder
pka	9.82±0.15(Predicted)
InChIKey	BLCLNMBMMGCOAS-URPVMXJPSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H334-H332-H317
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P261-P271-P304+P340-P312
Safety Statements	22-24/25
WGK Germany	3
HS Code	3504009000

Goserelin Chemical Properties,Uses,Production

Description

Goserelin is an analog of luteinizing hormone-releasing hormone (LHRH) useful in the treatment of malignancies responsive to hormonal manipulation. Administered parenterally in a biodegradable depot, goserelin is reportedly as effective as orchidectomy and oophorectomy in patients with advanced prostate carcinoma and pre-menopausal breast cancer.

Chemical Properties

White or almost white powder.

Uses

Labeled Goserelin, intended for use as an internal standard for the quantification of Goserelin by GC- or LC-mass spectrometry.

Side effects

Hot flashes (flushing), dizziness, headache, increased sweating, decreased sexual interest/ability, trouble sleeping, nausea, change in breast size, vaginal dryness, or hair loss may occur. Pain, bruising, bleeding, redness, or swelling at the injection site may also occur.
This medication may rarely make your blood sugar rise, which can cause or worsen diabetes.
Serious side effects including: symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating), signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion), fast/irregular heartbeat, severe dizziness, fainting.
In men using this medication for prostate cancer, a rare but very serious urinary blockage problem or spinal cord problem (compression) can occur, especially during the first month of treatment.

Drug interactions

Goserelin may be given on its own or is often combined with another hormone therapy such as tamoxifen or drugs known as aromatase inhibitors (anastrozole, exemestane and letrozole).
The risk or severity of QTc prolongation can be increased when Goserelin is combined with Clozapine. The risk or severity of methemoglobinemia can be increased when Goserelin is combined with Cocaine.

Goserelin Preparation Products And Raw materials

Raw materials

D-SER LIPOPHILIC SEPHADEX 1,4-Dioxane tert-Butyl nitrite 1-Butanol

HYDRAZINE Fmoc-O-tert-butyl-D-serine Potassium cyanate Nalpha-FMOC-L-Tryptophan Diethylamine

BOC-L-Leucine N,N'-Bis(9-fluorenylmethyloxycarbonyl)-L-histidine N,N'-Diisopropylcarbodiimide Divinylbenzene Piperidine

TRIFLOUROACETIC ACID Fmoc-L-Serine FMOC-TYR(2-BR-Z)-OH

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Preparation Products

Goserelin Suppliers

Global( 151)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Hardik Onco Care	08047642620	Ahmedabad, India	7	58	Inquiry
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	China	616	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10311	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry

Supplier	Advantage
Ralington Pharma	58
Manus Aktteva	34
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Hardik Onco Care	58
Nantong Guangyuan Chemicl Co,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shaanxi Pioneer Biotech Co., Ltd .	58

65807-02-5(Goserelin)Related Search:

Alarelin Acetate Taltirelin Goserelin EP Impurity G ((D-His2)-Goserelin) Gonadorelin Goserelin EP Impurity L ((D-Leu7)-Goserelin)

Gonadorelin impurity LHRH AC-SER-ASP-LYS-PRO-OH Amiodarone AMIODARONE IMPURITY E

GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER(T-BU)-LEU-ARG-PRO-AZAGLY-NH2],Goserelin acetate,Goserelin HCl AMIODARONE IMPURITY D Goserelin, Human GOSERELIN VALIDATION MIXTURE (D-HIS2)-GOSERELIN

4-D-SER-GOSERELIN (D-SER4)-GOSERELIN (D-LEU7)-GOSERELIN

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GOSERELIN ACETATE SALT (D-SER(TBU)6,AZAGLY10)-GONADOTROPIN-RELEASING HORMONE ACETATE SALT (D-SER(TBU)6,AZAGLY10)-LHRH ACETATE SALT (D-SER(TBU)6,AZAGLY10)-LUTEINIZING HORMONE-RELEASING FACTOR ACETATE SALT (D-SER(TBU)6,AZAGLY10)-LUTEINIZING HORMONE-RELEASING HORMONE ACETATE SALT PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2 ACETATE SALT 2-(aminocarbonyl)hydrazide decapeptidei d-ser(t-bu)(sup6)aza-gly(sup10)-gnrh ici118630 luteinizinghormone-releasingfactor(pig),6-(o-1,1-dimethylethyl)-d-serene)-1 1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-, 2-(aminocarbonyl)hydrazide Luteinizing hormone-releasing factor (pig), 6-[O-(1,1-dimethylethyl)-D-serine]-10-deglycinamide-, 2-(aminocarbonyl)hydrazide Goserelin 6-[O-(1，1-Dimethylethyl)-D-serine]-10-deglycirmmideluteinizing hormone-releasing factor(pig)2-(aminocarbonyl)hydrazide 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-O-(1,1-dimethylethyl)-D-Ser-L-Leu-L-Arg-L-Pro-ureido-NH2 Einecs 263-657-4 Pbtbo Phenol, 4,4'-(2,2-dioxido-3H-1,2-benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methyl-, sodium salt (1:1) Sodium alpha-(3,5-dibromo-2-methyl-4-oxo-2,5-cyclohexadienylidene)-alpha-(3,5-dibromo-4-hydroxyphenyl)toluenesulphonate Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-Gly-NH2 (D-Ser(tBu)6,Azagly10)-LHRH (free base) Goserelin (free base) GOSERELIN ACETATE PH. EUR. Human Goserelin Goserelin-d7 Geserelin Goserelin, Gosereline, Goserelinum, Goserelina Goserelin for NMR identification CRS Goserelin CRS Goserelin/Zoladex/Decapeptide I Goserelin USP/EP/BP Goserelin Deuterated Acetate DISCONTINUED Goserelin D10Q: What is Goserelin D10 Q: What is the CAS Number of Goserelin D10 Q: What is the storage condition of Goserelin D10 Q: What are the applications of Goserelin D10 Goserelin-d7Q: What is Goserelin-d7 Q: What is the CAS Number of Goserelin-d7 Goserelin Acetate(net) Zoladex Goserlin Goserelin validation mixture CRS Gosereline endo-5a-glycine-gonadorelin Goserelin-d7 Tritrifluoroacetate 65807-02-5 145781-95-6 C59H84N18O14 Pepetides peptides hormones