ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >p38 MAPK inhibitor >Skepinone-L
Skepinone-L
- CAS No.
- 1221485-83-1
- Chemical Name:
- Skepinone-L
- Synonyms
- CS-1010;CBS3830;SKEPINONE;Skepinone-L;Skepinone-L, >=98%;Skepinone-L (CBS3830);Skepinone-L USP/EP/BP;inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
- CBNumber:
- CB52628399
- Molecular Formula:
- C24H21F2NO4
- Molecular Weight:
- 425.42
- MOL File:
- 1221485-83-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:18
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
Skepinone-L Chemical Properties,Uses,Production
Description
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.
Uses
Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.
Skepinone-L Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 79)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26165 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Matrix Scientific | 803 788-9494 All other calls | United States | 6655 | 80 | Inquiry |
1221485-83-1(Skepinone-L)Related Search:
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Skepinone-L, >=98%
3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann
Skepinone-L
2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one
CS-1010
SKEPINONE
CBS3830
Skepinone-L USP/EP/BP
Skepinone-L (CBS3830)
(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one
inhibit,SkepinoneL,Skepinone-L,CBS-3830,Skepinone L,CBS 3830,Autophagy,p38 MAPK,Inhibitor
1221485-83-1
C24H21F2NO4
MAPK
Inhibitors