Pomalidomide-PEG4-CO2H
- CAS No.
- 2138440-81-8
- Chemical Name:
- Pomalidomide-PEG4-CO2H
- Synonyms
- Pomalidomide-PEG4-COOH;Poma-PEG4-COOH;Pomalidomide-PEG4-CO2H;POMALIDOMIDE-PEG4-CO 2 H;Pomalidomide 4'-PEG4-acid;Thalidomide-NH-PEG4-C2-COOH;1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid;Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-;1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber:
- CB54846410
- Molecular Formula:
- C24H31N3O10
- Molecular Weight:
- 521.52
- MOL File:
- 2138440-81-8.mol
- Modify Date:
- 2024/7/2 8:55:11
Pomalidomide-PEG4-CO2H Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.
Pomalidomide-PEG4-CO2H Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-PEG4-CO2H Suppliers
Global( 22)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | China | 2996 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| DC Chemicals | 021-58447131 13564518121 | China | 9412 | 58 | Inquiry |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | China | 11710 | 58 | Inquiry |
| Xi‘an Deeptech Biotechnology Co.,LTD | 15114901355 | China | 183 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48466 | 58 | Inquiry |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | China | 4824 | 58 | Inquiry |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | China | 10010 | 58 | Inquiry |
| ChemShuttle, Inc. | 0510-83588313-802 18800520310; | China | 3000 | 62 | Inquiry |
2138440-81-8(Pomalidomide-PEG4-CO2H)Related Search:
E3 Ligase Ligand-Linker Conjugates 1
POMALIDOMIDE-PEG2-CO2H
Pomalidomide-PEG1-azide
Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
Pomalidomide-PEG3-N3
Pomalidomide-PEG6-butyl iodide
Pomalidomide-PEG5-CO2H
POMALIDOMIDE-PEG1-CO2H
Pomalidomide-PEG3-Amine HCl salt
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POMALIDOMIDE-PEG4-CO 2 H
Pomalidomide-PEG4-CO2H
1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
Pomalidomide-PEG4-COOH
Thalidomide-NH-PEG4-C2-COOH
Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
Poma-PEG4-COOH
Pomalidomide 4'-PEG4-acid
2138440-81-8
peg