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POMALIDOMIDE-PEG1-CO2H

POMALIDOMIDE-PEG1-CO2H Structure
CAS No.
2139348-60-8
Chemical Name:
POMALIDOMIDE-PEG1-CO2H
Synonyms
3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid;Poma-PEG1-COOH;POMALIDOMIDE-PEG1-CO2H;Pomalidomide-PEG1-COOH;Pomalidomide-PEG1-C2-COOH;Pomalidomide 4'-PEG1-acid;Thalidomide-4-NH-PEG1-COOH;Thalidomide-NH-PEG1-C2-COOH;Pomalidomide-PEG1-CO2H >=95%;Thalidomide-4-NH-PEG1-C2-COOH
CBNumber:
CB14743861
Molecular Formula:
C18H19N3O7
Molecular Weight:
389.36
MOL File:
2139348-60-8.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:01
Request For Quotation

POMALIDOMIDE-PEG1-CO2H Properties

Boiling point 726.2±60.0 °C(Predicted)
Density 1.508±0.06 g/cm3(Predicted)
storage temp. 2-8°C
form powder or crystals
pka 4.29±0.10(Predicted)
color Yellow to brown

POMALIDOMIDE-PEG1-CO2H price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 901527 Pomalidomide-PEG1-CO2H ≥95% 2139348-60-8 50MG ₹67670 2022-06-14 Buy
Product number Packaging Price Buy
901527 50MG ₹67670 Buy

POMALIDOMIDE-PEG1-CO2H Chemical Properties,Uses,Production

Uses

Protein degrader builiding block Pomalidomide-PEG1-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-PEG1-CO2H Preparation Products And Raw materials

Raw materials

Preparation Products

POMALIDOMIDE-PEG1-CO2H Suppliers

Global( 42)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
MANPICK LABORATORIES PVT LTD +91-9949460828 +91-9949460828 Hyderabad, India 71 58 Inquiry
CR Corporation Limited +8613062833949 China 8647 58 Inquiry
Zhengzhou Lingzhiyue Technology Co., Ltd +86-0371-55074660 +86-13783527580 China 3152 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Nanjing Bicbiotechnology Co., Ltd +86-2552131256 +86-18251840740 China 6000 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Xian confluore Biological Technology Co., Ltd. +86-15680926068 +86-15680926068 China 2996 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Suzhou ARTK Medchem Co., Ltd. +86-512-68323658 +86-18168183658 China 39010 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 China 25415 58 Inquiry
Supplier Advantage
MANPICK LABORATORIES PVT LTD 58
CR Corporation Limited 58
Zhengzhou Lingzhiyue Technology Co., Ltd 58
LEAPCHEM CO., LTD. 58
Nanjing Bicbiotechnology Co., Ltd 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Xian confluore Biological Technology Co., Ltd. 58
Aladdin Scientific 58
Suzhou ARTK Medchem Co., Ltd. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58

POMALIDOMIDE-PEG1-CO2H Spectrum

POMALIDOMIDE-PEG1-CO2H(2139348-60-8)1HNMR

2139348-60-8(POMALIDOMIDE-PEG1-CO2H)Related Search:

Pomalidomide-PEG4-CO2H Pomalidomide-PEG3-CO2H POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG1-azide Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG5-CO2H E3 ligase Ligand-Linker Conjugates 50
Pomalidomide-PEG3-Amine HCl salt E3 Ligase Ligand-Linker Conjugates 1 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione E3 Ligase Ligand-Linker Conjugates 22 Pomalidomide-PEG2-butyl iodide
Pomalidomide-PEG4-azide Pomalidomide-PEG2-N3 POMALIDOMIDE-PEG1-ALKYNE
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Pomalidomide-PEG1-C2-COOH Pomalidomide-PEG1-COOH Pomalidomide-PEG1-CO2H >=95% POMALIDOMIDE-PEG1-CO2H 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid Thalidomide-4-NH-PEG1-COOH Thalidomide-NH-PEG1-C2-COOH Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]- 3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader Thalidomide-4-NH-PEG1-C2-COOH Poma-PEG1-COOH Pomalidomide 4'-PEG1-acid 3-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]propanoic Acid 3-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)propanoic acid 2139348-60-8 peg