Pomalidomide-PEG2-N3
- CAS No.
- 2267306-14-7
- Chemical Name:
- Pomalidomide-PEG2-N3
- Synonyms
- N3-PEG2-CH2CO-Poma;Pomalidomide-PEG2-N3;Pomalidomide-NH-CO-PEG2-N3;Acetamide, 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-(2-Azidoethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber:
- CB78118456
- Molecular Formula:
- C19H20N6O7
- Molecular Weight:
- 444.4
- MOL File:
- 2267306-14-7.mol
- Modify Date:
- 2024/7/2 8:55:17
Pomalidomide-PEG2-N3 Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Pomalidomide-PEG2-N3 Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-PEG2-N3 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | China | 2996 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | China | 12308 | 58 | Inquiry |
Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | China | 15527 | 58 | Inquiry |
Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | China | 49323 | 58 | Inquiry |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | China | 18488 | 58 | Inquiry |
Shaanxi borno biotechnology co., LTD | +86-13759708231 | China | 2351 | 58 | Inquiry |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | China | 9988 | 58 | Inquiry |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | China | 1386 | 58 | Inquiry |
Xi‘an Deeptech Biotechnology Co.,LTD | +86-15114901355 +86-15114901355 | China | 189 | 58 | Inquiry |
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