Anecortave Acetate
- CAS No.
- 7753-60-8
- Chemical Name:
- Anecortave Acetate
- Synonyms
- H6;Anecortave;Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate;Al 3789;Retaane;NSC 15475;NSC 24345;Anacorta acetate;Anechota acetate;anecortave acetate
- CBNumber:
- CB5501441
- Molecular Formula:
- C23H30O5
- Molecular Weight:
- 386.48
- MOL File:
- 7753-60-8.mol
- Modify Date:
- 2024/5/16 17:35:26
| Melting point | 230-234°C |
|---|---|
| alpha | D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3). |
| Boiling point | 551.8±50.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.47±0.60(Predicted) |
| color | Off-White to Beige |
Anecortave Acetate Chemical Properties,Uses,Production
Description
Anecortave acetate, an angiogenesis inhibitor, was launched in Australia by Alcon for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of untreatable blindness among people aged 65 to 74 years in the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable. Anecortave, an angiostatic steroid, down-regulates the expression MMP-2 and -9 to exert its antiangiogenic effects.
Chemical Properties
Off-White Solid
Uses
As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.
Enzyme inhibitor
This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model.
Anecortave Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Allmpus Laboratories Pvt Ltd | +91-9518738415 +91-9167862134 | Maharashtra, India | 657 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | China | 5873 | 58 | Inquiry |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | China | 973 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18632 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |