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5-hydroxy-l-tryptophan

5-hydroxy-l-tryptophan Structure
CAS No.
314062-44-7
Chemical Name:
5-hydroxy-l-tryptophan
Synonyms
5-HYDROXY-L-TRYPTOPHAN;5-HTP;L-5-HTP;L-HTP-OH;H-TRP(5-OH)-OH;5-HYDROXY-TRP-OH;H-5-HYDROXY-TRP-OH;5-HYDROXY-L-TRP-OH;C5-HYDROXY-L-TRYPTOPHAN;L-5-HYDROXYTRYPTOPHAN HYDRATE
CBNumber:
CB6110024
Molecular Formula:
C11H12N2O3
Molecular Weight:
220.22
MOL File:
314062-44-7.mol
MSDS File:
SDS
Modify Date:
2024/3/28 13:39:29

5-hydroxy-l-tryptophan Properties

Melting point 270 °C (dec.)(lit.)
Density 0.902 g/mL at 25 °C(lit.)
refractive index n20/D 1.4850(lit.)
Flash point 175 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: 10 mg/mL
form solid
color white
InChI InChI=1/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/s3
InChIKey LDCYZAJDBXYCGN-DJEYLCQNNA-N
SMILES C12C=C(C=CC=1NC=C2C[C@H](N)C(=O)O)O |&1:10,r|
CAS DataBase Reference 314062-44-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P501-P270-P264-P301+P310+P330-P405
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  YN7110000
3-10

5-hydroxy-l-tryptophan Chemical Properties,Uses,Production

Description

5-hydroxy-l-tryptophan (5-HTP) is a chemical byproduct of the protein building block L-tryptophan. It is produced commercially from the seeds of an African plant known as Griffonia simplicifolia. In vivo, it is produced from tryptophan by tryptophan hydroxylase (TPH), and its decarboxylation yields serotonin (5-hydroxytryptamine, 5-HT), a monoamine neurotransmitter involved in the modulation of mood, cognition, reward, learning, memory, sleep, and numerous other physiological processes. 5-HTP is both a drug and a natural component of some dietary supplements, and occurrence in both synthetic tryptophan and 5-HTP of toxic impurities has caused eosinophilia myalgia syndrome cases[1].

Uses

5-hydroxy-l-tryptophan is metabolized into serotonin and is thought to alleviate depression by enhancing serotonin neurotransmission. It is also used to treat fibromyalgia, insomnia, binge-eating, attention deficit disorder, and chronic headaches.

References

[1] Maffei, Massimo E. "5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology." International Journal of Molecular Sciences 22.1(2021):181.

5-hydroxy-l-tryptophan Preparation Products And Raw materials

Raw materials

Preparation Products

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314062-44-7(5-hydroxy-l-tryptophan)Related Search:

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