SUBSTANCE P
- CAS No.
- 12769-48-1
- Chemical Name:
- SUBSTANCE P
- Synonyms
- RPKPQFFGLM;SUBSTANCE P;RPKPQQFFGLM-NH2;SUBSTANCE P AMIDE;SUBSTANCE P (TYR8);SUBSTANCE P BOVINE;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
- CBNumber:
- CB6114259
- Molecular Formula:
- C63H98N18O13S
- Molecular Weight:
- 1347.63
- MOL File:
- 12769-48-1.mol
- Modify Date:
- 2023/5/4 17:34:32
SUBSTANCE P Chemical Properties,Uses,Production
Mechanism of action
Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.
Clinical Use
The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.
SUBSTANCE P Preparation Products And Raw materials
Raw materials
Preparation Products
SUBSTANCE P Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48467 | 58 | Inquiry |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | China | 6213 | 58 | Inquiry |
| Baoji Didu Pharmaceutical and Chemical Co., Ltd | 029-61856358 15829046862 | China | 10011 | 58 | Inquiry |
| Chem-Impex International, Inc. | 800 869-9290 US and Canada only | United States | 6740 | 64 | Inquiry |
| GenScript Corporation | 732 885 9188 | United States | 400 | 77 | Inquiry |
| The Peptide Laboratory | 707 745 1500 | United States | 224 | 30 | Inquiry |
| BIOMOL INTERNATIONAL, LP | (800) 942-0430 | United States | 1503 | 77 | Inquiry |
| Alexis Corporation | +41 61 926 8989 | Switzerland | 3599 | 74 | Inquiry |
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