thielavin A
![thielavin A Structure](CAS/GIF/71950-66-8.gif)
- CAS No.
- 71950-66-8
- Chemical Name:
- thielavin A
- Synonyms
- thielavin A;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester;Benzoic acid, 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester
- CBNumber:
- CB61386873
- Molecular Formula:
- C29H30O10
- Molecular Weight:
- 538.54
- MOL File:
- 71950-66-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/21 10:59:17
thielavin A Chemical Properties,Uses,Production
Description
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).
Uses
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.
thielavin A Preparation Products And Raw materials
Raw materials
Preparation Products
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BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
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TargetMol Chemicals Inc. | 15002134094 | China | 28091 | 58 | Inquiry |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | China | 56077 | 58 | Inquiry |
Beijing Bolide Biotechnology Co., Ltd. | 010-51653916 | CHINA | 6172 | 58 | Inquiry |
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Xiamen Huijia Biological Technology Co., Ltd. | 0592-6020891 | CHINA | 6979 | 58 | Inquiry |
Shanghai Hao Biological Technology Co., Ltd. | 021-58116080 18019263206 | CHINA | 6921 | 58 | Inquiry |