thielavin A
- CAS No.
- 71950-66-8
- Chemical Name:
- thielavin A
- Synonyms
- thielavin A;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester;Benzoic acid, 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester
- CBNumber:
- CB61386873
- Molecular Formula:
- C29H30O10
- Molecular Weight:
- 538.54
- MOL File:
- 71950-66-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/10/28 23:16:16
thielavin A Chemical Properties,Uses,Production
Description
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).
Uses
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.
thielavin A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32222 | 58 | Inquiry |
| Aladdin Scientific | United States | 52924 | 58 | Inquiry | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9803 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24719 | 58 | Inquiry |
| Absin Bioscience Inc. | 021-38015121-8802 | CHINA | 6208 | 58 | Inquiry |
| Santa Cruz Biotechnology Inc | 60936350 | China | 222068 | 58 | Inquiry |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | China | 9522 | 58 | Inquiry |
| Neobioscience Co., Ltd. | 4006-800-892 | CHINA | 6207 | 58 | Inquiry |
| Shanghai Weiyite Biotechnology Co., Ltd | 15317051735 | China | 9736 | 58 | Inquiry |