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Maprotiline

CAS No.: 10262-69-8

Chemical Name:: Maprotiline

Synonyms: 276-Ba;Ludiomil;MAPROTILINE;Maprotyline;maprotylina;Maprotiline USP/EP/BP;Maprotiline (base and/or unspecified salts);n-methyl-10-ethanoanthracene-9(10h)-propylamine;n-methyl-9,10-ethanoanthracene-9(10h)-propanamine;N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine

CBNumber:: CB6149440

Molecular Formula:: C20H23N

Molecular Weight:: 277.4

MOL File:: 10262-69-8.mol

MSDS File:: SDS

Modify Date:: 2023/6/2 14:42:00

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Maprotiline Properties

Melting point	92-94°
Boiling point	410.26°C (rough estimate)
Density	0.9801 (rough estimate)
refractive index	1.4900 (estimate)
pka	pKa 10.5±0.2(H2O t=25.0) (Uncertain)
Water Solubility	833.4ug/L(22.5 ºC)
CAS DataBase Reference	10262-69-8(CAS DataBase Reference)
NIST Chemistry Reference	Maprotiline(10262-69-8)

SAFETY

Risk and Safety Statements

RIDADR	3249
HazardClass	6.1(b)
PackingGroup	III
Toxicity	LD50 oral in rat: 760mg/kg

Maprotiline Chemical Properties,Uses,Production

Uses

Maprotiline disrupts neuronal reuptake of monoamines in the CNS and possesses moderate tranquilizing and cholinergic activity. It improves mood significantly and relieves feelings of fear. Maprotiline is used in various forms of depression accompanied by a feeling of fear and irritability.

Mechanism of action

Maprotiline is slowly but completely absorbed from the GI tract, and like the other TCAs, it is metabolized by the polymorphic CYP2D6 and CYP2C19 isoforms in the liver, primarily to pharmacologically active N-desmethylmaprotiline and to maprotiline-N-oxide.Maprotiline is distributed into breast milk at concentrations similar to those found at steady state in maternal blood. The elimination half-life of maprotiline averages 43 hours (60–90 hours for its N-desmethyl metabolite).Maprotiline shares the toxic potentials of the TCAs, and the usual precautions of TCA administration should be observed.

Clinical Use

Maprotiline is a secondary amine dibenzobicyclooctadiene (a tetracyclic antidepressant) that differs structurally from the TCAs by having an ethylene bridge in its central ring, resulting in a rigid bicyclomolecular skeleton .
Maprotiline exhibits the highest affinity and selectivity for the NE transporter. Its antidepressant mechanism of action is similar to that of desipramine, with an onset of action of up to 2 to 3 weeks.

Side effects

Although most of the TCAs have been reported to induce seizures, it is generally recognized that maprotiline may be associated with a higher incidence of dose-dependent seizures compared with the other secondary TCAs. Maprotiline has been reported to produce sedation in depressed patients and to reduce aggressive behavior in animals. Maprotiline also shares the anticholinergic and cardiovascular effects of the secondary TCAs and may cause electrocardiographic changes, tachycardia, and postural hypotension.

Maprotiline Preparation Products And Raw materials

Raw materials

Anthracene Methylamine 3-ANTHRACEN-9-YL-PROPIONIC ACID ETHYLENE Lithium Aluminum Hydride

Thionyl chloride N-Methyl-9,10-ethanoanthracene-9(10H)-propionamide 9,10-Ethanoanthracene-9(10H)-propionic acid Anthrone

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Preparation Products

Maprotiline Suppliers

Global( 45)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	China	9003	58	Inquiry
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	China	35451	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	49999	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24017	58	Inquiry
Shanghai Beiwanta Biotechnology Co., Ltd.	021-67187366 19901745723	China	9247	58	Inquiry
Shanghai Maclean Biochemical Technology Co., LTD	021-50706066 15221275939	China	29803	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Shaanxi Didu New Materials Co. Ltd	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
TargetMol Chemicals Inc.	58
Shanghai Beiwanta Biotechnology Co., Ltd.	58
Shanghai Maclean Biochemical Technology Co., LTD	58

10262-69-8(Maprotiline)Related Search:

METSULFURON METHYL Tribenuron methyl Thiophanate-methyl Pirimiphos-methyl Kresoxim-methyl

Methyl acetate Methyl salicylate CLOTHIAPINE Setiptiline Methyl

Parathion-methyl MAPROTILINE HYDROCHLORIDE Methyl bromide Levoprotiline (-)-2-[METHYLAMINO]-1-PHENYLPROPANE

Levoprtiline MAPROTILINE-D3 MAPROTILINE IMPURITY D

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MAPROTILINE n-methyl-9,10-ethanoanthracene-9(10h)-propanamine Maprotiline (base and/or unspecified salts) 9,10-Ethano-9,10-dihydro-9-(3-methylaminopropyl)anthracene Maprotyline N-Methyl-9,10-ethanoanthracene-9(10H)-propan-1-amine 276-Ba 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)propylmethylamine 9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl- 9,10-Ethanoanthracene-9(10H)-propylamine, N-methyl- Ludiomil maprotylina n-methyl-10-ethanoanthracene-9(10h)-propylamine N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine Maprotiline USP/EP/BP MaprotilineQ: What is Maprotiline Q: What is the CAS Number of Maprotiline Q: What is the storage condition of Maprotiline Q: What are the applications of Maprotiline 10262-69-8