Pristinamycin IA

Pristinamycin IA Structure
CAS No.
3131-03-1
Chemical Name:
Pristinamycin IA
Synonyms
PA 114B;NSC 92554;mikamycin B;MikaMycin IA;Ostreogrycin B;VirginiaMycin B;Streptogramin B;Pristinamycin IA;Pristinamycin ⅠA;PristinaMycin P 1
CBNumber:
CB62079233
Molecular Formula:
C45H54N8O10
Molecular Weight:
866.96
MOL File:
3131-03-1.mol
Modify Date:
2024/7/7 20:48:41

Pristinamycin IA Properties

Melting point 198°
alpha D22 -57.5° (c = 0.25 in ethanol)
Boiling point 780.3°C (rough estimate)
Density 1.1881 (rough estimate)
refractive index 1.6910 (estimate)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain)
color Pale Yellow

SAFETY

Risk and Safety Statements

RIDADR  3172
HazardClass  6.1(b)
PackingGroup  III

Pristinamycin IA Chemical Properties,Uses,Production

Uses

One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810).

Definition

ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis s including methicillin-resistant Staphylococcus aureus.

Contact allergens

Pristinamycin is a systemic antibiotic of the synergistins/ streptogramins class, composed of two subunits: pristinamycin IA and pristinamycin IIA. It induces several types of drug reactions such as maculo-papular exanthema, systemic dermatitis, or acute generalized exanthematous pustulosis. Some patients have been previously skin-sensitized by virginiamycin. Crossreactivity is expected to virginiamycin and to the associated dalfopristin and quinupristin.

Pristinamycin IA Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 44)Suppliers
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Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry

Pristinamycin IA Spectrum

N-[(3-Hydroxy-2-pyridinyl)carbonyl]-L-threonyl-(2R)-2-aMinobutanoyl-L-prolyl-4-(diMethylaMino)-N-Methyl-L-phenylalanyl-(2S)-4-oxo-2-piperidinecarbonyl-(2S)-2-phenylglycine (6-13)-lactone NSC 92554 PA 114B PristinaMycin P 1 Ostreogrycin B, PristinaMycin IA, StreptograMin B, Syncothrecin B1, Synergistin B, VernaMycin Balpha, VirginiaMycin 1A, NSC 125176, 14725-1, PA 114B, RP 12535 VirginiaMycin B mikamycin B N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo(L-Thr*-D-Abu-L-Pro-N-methyl-4-(dimethylamino)-L-Phe-4-oxo-L-2-piperidinecarbonyl-L-phenyl Gly-) Ostreogrycin B Pristinamycin IA Streptogramin B PristinaMycin IA DISCONTINUED 4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]virginiaMycin S1 Antibiotic PA 114B Antibiotic PA 114B1 MikaMycin IA Pristinamycin IA, >95% Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]- Antibiotic,ribosome,Bacterial,macrolactone,vinblastine,inhibit,Pristinamycin IA,Inhibitor,P-glycoprotein Pristinamycin ⅠA 3131-03-1 C45H54N8O10 Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals