6-Maleimidocaproic acid
- CAS No.
- 55750-53-3
- Chemical Name:
- 6-Maleimidocaproic acid
- Synonyms
- 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid;EMCA;6-MALEIMIDOHEXANOIC ACID;6-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)hexanoic acid;MalHex;Maleimide-(CH2)5-COOH;6-MaleimidocaproicAci;Mal-(CH2)5-COOH (EMCA);6-MALEIMIDOCAPROIC ACID;6-MaleiMidocapronic acid
- CBNumber:
- CB6300928
- Molecular Formula:
- C10H13NO4
- Molecular Weight:
- 211.21
- MOL File:
- 55750-53-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/19 14:01:02
| Melting point | 86-91 °C |
|---|---|
| Boiling point | 407.3±28.0 °C(Predicted) |
| Density | 1.285±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | Powder |
| pka | 4.74±0.10(Predicted) |
| color | White to pale yellow |
| Water Solubility | Soluble in water, methanol, ethanol, dimethyl sulfoxide. Insoluble in ether. |
| Sensitive | Moisture Sensitive |
| BRN | 1532405 |
| InChIKey | WOJKKJKETHYEAC-UHFFFAOYSA-N |
| CAS DataBase Reference | 55750-53-3(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo- (55750-53-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-41-37/38 | |||||||||
| Safety Statements | 26-36-39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29251900 | |||||||||
| NFPA 704 |
|
6-Maleimidocaproic acid price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 755842 | 6-Maleimidohexanoic acid 90% (GC) | 55750-53-3 | 25G | ₹11983.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 63176 | 6-Maleimidohexanoic acid ≥98.0% (HPLC) | 55750-53-3 | 1G | ₹32312.63 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M2338 | 6-Maleimidohexanoic Acid min. 98.0 % | 55750-53-3 | 1G | ₹2800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M2338 | 6-Maleimidohexanoic Acid min. 98.0 % | 55750-53-3 | 5G | ₹13000 | 2022-05-26 | Buy |
6-Maleimidocaproic acid Chemical Properties,Uses,Production
Chemical Properties
White to yellow solid, powder, crystals or crystaline powder.
Definition
ChEBI: 6-Maleimidocaproic acid is a medium-chain fatty acid. It contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Application
6-Maleimidocaproic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent. It can be widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins. Spacer Arm: 9.4 Angstroms. Probe for thiol groups (SH-groups) in membrane proteins.
Synthesis
Maleic anhydride (29.4 g, 0.3 mol) and 6-aminocaproic acid (39.35 g, 0.3 mol) were refluxed in
glacial acetic acid (900 mL) for 16 h. Acetic anhydride (30.6 g, 0.3 mol) was added dropwise over
a period of 2 hand reflux was continued for 1 h. The acetic acid was removed under vacuum at 70
°C to yield yellow syrup which solidified. The material was chromatographed over silica using
dichloromethane-methanol-acetic acid (100:5:1) affording a crystalline solid (6-Maleimidocaproic acid).
6-Maleimidocaproic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | CHINA | 272 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
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