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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Endocrinology & Hormones >Estrogen / progestogen Receptor Antagonists >Raloxifene hydrochloride

Raloxifene hydrochloride

Raloxifene hydrochloride Structure
CAS No.
82640-04-8
Chemical Name:
Raloxifene hydrochloride
Synonyms
CS-127;ly156758;KEOXIFENE;LY 139481;AKOS 92138;RALOXIFENE HCL;LY156758 hydrochloride;LY139481 hydrochloride;Latilavir secondary VI;Evista (Raloxifene HCl)
CBNumber:
CB6302366
Molecular Formula:
C28H28ClNO4S
Molecular Weight:
510.04
MOL File:
82640-04-8.mol
Modify Date:
2024/4/28 19:50:54
Request For Quotation

Raloxifene hydrochloride Properties

Melting point 250-253°C
storage temp. 2-8°C
solubility DMSO: 28 mg/mL, soluble
form solid
color light yellow
λmax 286nm(lit.)
Merck 14,8098
BCS Class 2
InChIKey BKXVVCILCIUCLG-UHFFFAOYSA-N
SMILES C1(C(=O)C2C=CC(OCCN3CCCCC3)=CC=2)C2C=CC(O)=CC=2SC=1C1C=CC(O)=CC=1.Cl
CAS DataBase Reference 82640-04-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H351-H361d
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25
WGK Germany  3
RTECS  PC4956925
HS Code  2934990002

Raloxifene hydrochloride price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) R1402 Raloxifene hydrochloride solid 82640-04-8 500MG ₹53432.2 2022-06-14 Buy
Sigma-Aldrich(India) R1402 Raloxifene hydrochloride solid 82640-04-8 1G ₹99535.88 2022-06-14 Buy
Sigma-Aldrich(India) PHR1852 Raloxifene Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 82640-04-8 500MG ₹15144.18 2022-06-14 Buy
Product number Packaging Price Buy
R1402 500MG ₹53432.2 Buy
R1402 1G ₹99535.88 Buy
PHR1852 500MG ₹15144.18 Buy

Raloxifene hydrochloride Chemical Properties,Uses,Production

Description

Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.

Chemical Properties

Light-Yellow Solid

Uses

Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Raloxifene hydrochloride Preparation Products And Raw materials

Raw materials

(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)(6-METHOXY-2-(4-METHOXYPHENYL)BENZO[B]THIOPHEN-3-YL)METHANONE 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE

Preparation Products

Raloxifene

Raloxifene hydrochloride Suppliers

Global( 474)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
TYNDAL LABS PVT LTD +91-8008166674 +91-8008166674 AndhraPradesh, India 95 58 Inquiry
Darsh PharmaChem Pvt Ltd +91-9712983850 +91-9712983850 Gujarat, India 33 58 Inquiry
Apotex Pharmachem India Pvt Ltd +91-8022891034 +91-8022891000 Karnataka, India 109 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Aarti Drugs Ltd (part of Aarti Group of Industries) +91-2224019025 +91-9136988221 Maharashtra, India 57 58 Inquiry
Srini Pharmaceuticals Pvt Ltd +91-9866124354 +91-9618884942 Telangana, India 29 58 Inquiry
Glochem Industries Pvt Ltd +91-7893133369 Telangana, India 8 58 Inquiry
Medilux Laboratories Pvt Ltd +91-7292409991 +91-9819666688 Madhya Pradesh, India 102 58 Inquiry
Alfa Omega Pharma +91-8050045945 +91-9972665399 Maharashtra, India 126 58 Inquiry
Supplier Advantage
Dr. Reddy's Laboratories Ltd 58
TYNDAL LABS PVT LTD 58
Darsh PharmaChem Pvt Ltd 58
Apotex Pharmachem India Pvt Ltd 58
Hetero Drugs Limited 58
Aarti Drugs Ltd (part of Aarti Group of Industries) 58
Srini Pharmaceuticals Pvt Ltd 58
Glochem Industries Pvt Ltd 58
Medilux Laboratories Pvt Ltd 58
Alfa Omega Pharma 58

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Raloxifene hydrochloride Spectrum

Raloxifene hydrochloride(82640-04-8)1HNMR

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RALOXIFENE HCL Raloxifene hydrochloride,Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride Raloxifene Hydrochloride (200 mg) 2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol hydrochloride (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone hydrochloride Evista(Raloxifene Hydrochloride (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanon [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone,hydrochloride (1:1) LY156758 (Keoxifene) HCl Evista (Raloxifene HCl) Methanone,[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-,hydrochloride (1:1) (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)metha RALOXIFENE HYDROCHLORIDE KEOXIFENE KEOXIFENE HYDROCHLORIDE LY 139481 AKOS 92138 ly156758 methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidin [6-HYDROXY-2-(4-HYDROXYPHENYL)BENZO[B]THIEN-3-YL][4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-METHANONE HYDROCHLORIDE [6-Hydroxy-2-(4-Hydroxyphenyl) benzo[b]thien-3-yl] RALOXIFENEHYDROCHLORIDE(SUBJECTTOPATENTFREE) Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl) ethoxy]phenyl]methanone HCl Raloxifene Hydrochloride Tablets LY156758 hydrochloride CS-127 LY139481 hydrochloride Raloxifene hydrochloride,>98% [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride Raloxifene hydrochloride USP/EP/BP Latilavir secondary VI Raloxifene hydrochloride Evista [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone Raloxefene hydrochloride Raloxifene HCl (LY-139481) Raloxifene hydrochloride (Y0001134) Raloxifene Hydrochloride (1598201) (1aΞ,7aΞ)-1a-methyl-7a-[(2E,7RS,11RS)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione (trans-epoxyphytomenadione isomers) 82640-04-8 28640-04-8 C28H27NO4S.HCl C28H27NO4SClH C28H27NO4SHClC28H28ClNO4S API Pharmaceutical intermediate Inhibitors antifungal Aromatics Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Active Pharmaceutical Ingredients Raloxifene Intracellular receptor