Calcium phosphate dibasic
- CAS No.
- 7757-93-9
- Chemical Name:
- Calcium phosphate dibasic
- Synonyms
- DICALCIUM PHOSPHATE;MONOCALCIUM PHOSPHATE;DIBASIC CALCIUM PHOSPHATE;CALCIUM HYDROGEN PHOSPHATE;Anhydrous Dibasic Calcium Phosphate;CALCIUM ORTHOPHOSPHATE;Monetite;calciumdibasicphosphate;CALCIUM PHOSPHATE, DIBASIC;CALCIUM HYDROGEN ORTHOPHOSPHATE
- CBNumber:
- CB6344120
- Molecular Formula:
- CaHO4P
- Molecular Weight:
- 136.06
- MOL File:
- 7757-93-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/10/31 18:15:48
| Melting point | 370°C(decomposition) |
|---|---|
| Density | 2.306（16℃） |
| RTECS | TB8528000 |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid. |
| form | gel (aged) |
| color | White |
| PH | 7 (10g/l, H2O, 20°C) suspension |
| Water Solubility | Sparingly soluble in water, practically insoluble in cold water. |
| Merck | 13,1697 |
| Solubility Product Constant (Ksp) | pKsp: 7 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | FUFJGUQYACFECW-UHFFFAOYSA-L |
| LogP | -2.148 (est) |
| CAS DataBase Reference | 7757-93-9(CAS DataBase Reference) |
| EPA Substance Registry System | Calcium hydrogen phosphate (7757-93-9) |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25-22 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2835 25 00 | |||||||||
| Toxicity | LD50 orally in Rabbit: 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg | |||||||||
| NFPA 704 |
|
Calcium phosphate dibasic price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C8606 | Dibasic Calcium Phosphate meets USP testing specifications | 7757-93-9 | 500G | ₹8660 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7263 | Calcium phosphate dibasic 98.0-105.0% | 7757-93-9 | 100G | ₹3301.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C8606 | Dibasic Calcium Phosphate meets USP testing specifications | 7757-93-9 | 2.5KG | ₹25568.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7263 | Calcium phosphate dibasic 98.0-105.0% | 7757-93-9 | 500G | ₹7144.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7263 | Calcium phosphate dibasic 98.0-105.0% | 7757-93-9 | 2.5KG | ₹12535.35 | 2022-06-14 | Buy |
Calcium phosphate dibasic Chemical Properties,Uses,Production
Chemical Properties
Anhydrous dibasic calcium phosphate is a white, odorless, tasteless powder or crystalline solid. It occurs as triclinic crystals.
Physical properties
White triclinic crystal; density 2.92 g/cm3 (anhydrous) and 2.31 g/cm3 (dihy drate); hardness 3.5 Mohs; decomposes on heating; inosluble in water and alcohol; KSP 2.7x10-7; soluble in dilute mineral acid.
Uses
Replenisher (calcium); pharmaceutic aid (tablet base).
Production Methods
Calcium phosphates are usually prepared by reacting very pure phosphoric acid with calcium hydroxide, Ca(OH)2 obtained from limestone, in stoichiometric ratio in aqueous suspension followed by drying at a temperature that will allow the correct hydration state to be achieved. After drying, the coarse-grade material is obtained by means of a classification unit; the fine particle-size material is obtained by milling. Dibasic calcium phosphate, anhydrous, may also be prepared by spray-drying.
Pharmaceutical Applications
Anhydrous dibasic calcium phosphate is used both as an excipient
and as a source of calcium in nutritional supplements. It is used
particularly in the nutritional/health food sectors. It is also used in
pharmaceutical products because of its compaction properties, and
the good flow properties of the coarse-grade material. The
predominant deformation mechanism of anhydrous dibasic calcium
phosphate coarse-grade is brittle fracture and this reduces the
strain-rate sensitivity of the material, thus allowing easier transition
from the laboratory to production scale. However, unlike the
dihydrate, anhydrous dibasic calcium phosphate when compacted
at higher pressures can exhibit lamination and capping. This
phenomenon can be observed when the material represents a
substantial proportion of the formulation, and is exacerbated by the
use of deep concave tooling. This phenomenon also appears to be
independent of rate of compaction.
Anhydrous dibasic calcium phosphate is abrasive and a lubricant
is required for tableting, for example 1% w/w magnesium stearate
or 1% w/w sodium stearyl fumarate.
Two particle-size grades of anhydrous dibasic calcium phosphate
are used in the pharmaceutical industry. Milled material is typically
used in wet-granulated or roller-compacted formulations. The
‘unmilled’ or coarse-grade material is typically used in directcompression
formulations.
Anhydrous dibasic calcium phosphate is nonhygroscopic and
stable at room temperature. It does not hydrate to form the
dihydrate.
Anhydrous dibasic calcium phosphate is used in toothpaste and
dentifrice formulations for its abrasive properties.
Agricultural Uses
Dicalcium phosphate (CaHPO4) is made from calcium carbonate and phosphoric acid. It contains 34% citrate- soluble phosphorus pentoxide (P2O5). It is not commonly used as a fertilizer, but is used as a supplement to animal feed.
Safety Profile
Skin and eye irritant. A nuisance dust.
Safety
Dibasic calcium phosphate anhydrous is widely used in oral pharmaceutical products, food products, and toothpastes, and is generally regarded as a relatively nontoxic and nonirritant material.
storage
Dibasic calcium phosphate anhydrous is a nonhygroscopic,
relatively stable material. Under conditions of high humidity it
does not hydrate to form the dihydrate.
The bulk material should be stored in a well-closed container in a
dry place.
Purification Methods
Crystallise it from a near-saturated solution in 50% aqueous reagent grade phosphoric acid at 100o by filtering through fritted glass and cooling to room temperature. The crystals are filtered off, and this process is repeated three times using fresh acid. For the final crystallisation the solution is cooled slowly with constant stirring to give thin plate crystals that are filtered off on a fritted glass funnel, washed free of acid with anhydrous acetone and dry in a vacuum desiccator [Egan et al.J Am Chem Soc 78 1811 1956].
Incompatibilities
Dibasic calcium phosphate should not be used to formulate
tetracyline antibiotics.
The surface of milled anhydrous dibasic calcium phosphate is
alkaline and consequently it should not be used with drugs that
are sensitive to alkaline pH. However, reports suggest there are
differences in the surface alkalinity/acidity between the milled and
unmilled grades of anhydrous dibasic calcium phosphate; the
unmilled form has an acidic surface environment. This difference
has important implications for drug stability, particularly when
reformulating from, e.g. roller compaction to direct compression,
when the particle size of the anhydrous dibasic calcium phosphate
might be expected to change.
Dibasic calcium phosphate dihydrate has been reported to be
incompatible with a number of drugs and excipients, and many of
these incompatibilities are expected to occur with dibasic calcium
phosphate, anhydrous; see Calcium phosphate, dibasic dihydrate.
Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Calcium phosphate dibasic Preparation Products And Raw materials
Raw materials
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| Prachin Chemical | +91-7922821740 +91-9825015645 | Gujarat, India | 21 | 58 | Inquiry |
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