Verteporfin
- CAS No.
- 129497-78-5
- Chemical Name:
- Verteporfin
- Synonyms
- BPD-MA;Visudyne;CL 318952;NSC6242;NSC 6242;NSC-6242;VERTEPIRFIN;Verteporfin;Verteprofin;Verteporfen
- CBNumber:
- CB6505794
- Molecular Formula:
- 2C41H42N4O8
- Molecular Weight:
- 1437.61
- MOL File:
- 129497-78-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
| HS Code | 2933997500 |
Verteporfin price More Price(2)
Verteporfin Chemical Properties,Uses,Production
Description
Verteporfin was introduced in Switzerland as a second-generation photosensitizer for photodynamic therapy of wet age-related macular degeneration in patients with subfoveal choroidal neovascularisation. It is constituted of a mixture of two regioisomers resulting from nonselective monohydrolysis of the methyl tetraester. Upon irradiation with a lowenergy nonheat-generating laser light of 689nm wavelength, both regioisomeric benzoporphyrins are responsible for the local generation of singlet oxygen leading to free radical damage of neovascular endothelial cells in subfoveal lesions of patients with agerelated macular degeneration. The lipophilic drug is injected i.v. as a liposomal formulation in order to favor its uptake by plasma lipoproteins and distribution to cells with a high expression of low density lipoprotein receptors such as tumor and neovascular endothelial cells. Verteporfin is also being developed for the treatment of other eye diseases, nonmelanoma skin cancer and psoriasis.
Uses
Verteporfin is a photosensitizer that is used in photodynamic therapy (PDT). Verteporfin can accumulate in tumor tissues allowing for 30 to 150 minutes optimal PDT after intravenous administration.
References
References/Citations:
(1)Saini et al. (2021), Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells; Cancer Cell Int., 21 52
(2)Vigneswaran et al. (2021), YAP/TAZ Transcription Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma; Clin. Cancer Res., 27 1553
(3)Donohue et al. (2014), Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin; PLoS One, 9 e114964
(4)Luo et al. (2021), Src-Yap1 signaling axis controls the trophectoderm and epiblast lineage differentiation in mouse embryonic stem cells; Stem Cell Res., 54 102413
(5)Bressler et al. (2000), Photodynamic therapy with verteporfin (Visudyne): impact on ophthalmology and visual sciences; Invest. Ophthamol. Vis. Sci., 41 624
Verteporfin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29859 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49732 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | China | 3254 | 58 | Inquiry |
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