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ChemicalBook > Product Catalogue >API >Specialty drugs >Ophthalmic drugs >Verteporfin

Verteporfin

Verteporfin Structure
  • ₹12297.2 - ₹50076.45
  • Product name: Verteporfin
  • CAS: 129497-78-5
  • MF: 2C41H42N4O8
  • MW: 1437.61
  • EINECS:
  • MDL Number:MFCD11982858
  • Synonyms:Verteporfin(DB00460);Verteprofin;Verteporfin;Verteporphin;24H,26H-Benzo[b]porphine-9,13-dipropanoic acid, 18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-, monomethyl ester, (4R,4aS)-rel-;VERTEPIRFIN;9-methyl (I)13-methyl (II)trans-(±)- 18-ethenyl- 4,4a-dihydro-3,4 -bis(methoxycarbonyl)- 4a,8,14,19-tetramethyl- 23H,25H-benzo[b]porphine- 9,13- dipropanoate;(4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-Benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0534
  • Product descriptionVerteporfin ≥94% (HPLC)
  • Packaging5MG
  • Price₹12297.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0534
  • Product descriptionVerteporfin ≥94% (HPLC)
  • Packaging25MG
  • Price₹50076.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0534 Verteporfin ≥94% (HPLC) 5MG ₹12297.2 2022-06-14 Buy
Sigma-Aldrich(India) SML0534 Verteporfin ≥94% (HPLC) 25MG ₹50076.45 2022-06-14 Buy

Properties

storage temp. :-20°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
form :powder
color :Black
Stability :Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :YHNBVDZVUQFVLS-RDSGBMLISA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Verteporfin is a photosensitizer used during photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. It accumulates in these abnormal blood vessels and, when activated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces a highly reactive short-lived singlet oxygen and other reactive oxygen radicals, generating local damage to the endothelium and vessel occlusion. Verteporfin can also inhibit autophagosome formation by directly targeting and modifying p62, a scaffold and adaptor protein that binds both polyubiquitinated proteins destined for degradation and LC3 on autophagosomal membranes.

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