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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >Teniposide

Teniposide

Teniposide Structure
  • ₹3400 - ₹30645.58
  • Product name: Teniposide
  • CAS: 29767-20-2
  • MF: C32H32O13S
  • MW: 656.65
  • EINECS:249-831-2
  • MDL Number:MFCD00866516
  • Synonyms:(5R,5aα)-5α,8,8aβ,9β-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4-O,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;4'-Demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene β-D-glucopyranoside);4’-Demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-;4'-Demethylepipodophyllotoxin thenylidene glucoside;Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-o-2-thienylidene-.beta.-D-glucopyranoside);Furo[3',4':6,7]naphtho[2,3-D]-1,3-dioxol-6(5ah)-one, 5,8,8A,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-o-(2-thienylmethylene)-.beta.-D-glucopyranosyl]oxy]-, [5R-(5.alpha.,5A.beta.,8A.alpha.,9.beta.)]-;(10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-diMethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-12-one;Teniposide(VuMon)
4 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 20MG
  • 50MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberT3109
  • Product descriptionTeniposide
  • Packaging20MG
  • Price₹3400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT3109
  • Product descriptionTeniposide
  • Packaging100MG
  • Price₹12700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0609
  • Product descriptionTeniposide ≥97% (HPLC)
  • Packaging10MG
  • Price₹7653.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0609
  • Product descriptionTeniposide ≥97% (HPLC)
  • Packaging50MG
  • Price₹30645.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T3109 Teniposide 20MG ₹3400 2022-05-26 Buy
TCI Chemicals (India) T3109 Teniposide 100MG ₹12700 2022-05-26 Buy
Sigma-Aldrich(India) SML0609 Teniposide ≥97% (HPLC) 10MG ₹7653.28 2022-06-14 Buy
Sigma-Aldrich(India) SML0609 Teniposide ≥97% (HPLC) 50MG ₹30645.58 2022-06-14 Buy

Properties

Melting point :244-247°C
Boiling point :650.86°C (rough estimate)
alpha :D20 -107° (9:1 chloroform/methanol)
Density :1.2568 (rough estimate)
refractive index :1.5530 (estimate)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
pka :10.13(at 25℃)
form :powder
color :white to beige
optical activity :[α]/D -100 to -115°, c = 1 in chloroform/methanol (9:1)
λmax :283nm(MeOH)(lit.)
Merck :14,9145
Stability :Hygroscopic
CAS DataBase Reference :29767-20-2(CAS DataBase Reference)
IARC :2A (Vol. 76) 2000

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis. Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.

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