5-Bromo-7-azaindole
- CAS No.
- 183208-35-7
- Chemical Name:
- 5-Bromo-7-azaindole
- Synonyms
- 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;3-Bromo-7H-pyrrolo[2,3-b]pyridine;SW-57;SWF-57;SKL277;EOS-60661;5-BROMO AZAINDOLE;5-bromo-7-azindole;5-BROMO-7-AZAINDOLE;5-Bromo-7-azaindole,96%
- CBNumber:
- CB6756981
- Molecular Formula:
- C7H5BrN2
- Molecular Weight:
- 197.03
- MOL File:
- 183208-35-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/27 17:30:52
| Melting point | 176-180 °C |
|---|---|
| Boiling point | 357.4±42.0 °C(Predicted) |
| Density | 1.79±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 6.25±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to yellow |
| InChI | InChI=1S/C7H5BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10) |
| InChIKey | LPTVWZSQAIDCEB-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=CC(Br)=CN=2 |
| LogP | 1.8 at 25℃ and pH7 |
| CAS DataBase Reference | 183208-35-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
5-Bromo-7-azaindole price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 692549 | 5-Bromo-7-azaindole 97% | 183208-35-7 | 1G | ₹5661.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 692549 | 5-Bromo-7-azaindole 97% | 183208-35-7 | 5G | ₹17666.4 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B3588 | 5-Bromo-1H-pyrrolo[2,3-b]pyridine min. 98.0 % | 183208-35-7 | 1G | ₹2800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B3588 | 5-Bromo-1H-pyrrolo[2,3-b]pyridine min. 98.0 % | 183208-35-7 | 5G | ₹10500 | 2022-05-26 | Buy |
5-Bromo-7-azaindole Chemical Properties,Uses,Production
Chemical Properties
White to light brown powder or crystal
Synthesis
In the 250 ml flask is sequentially added in 50 ml ethanol and 5-bromo-1-hydrogen pyrrolo [2,3 - the b] pyridine -2 - ketone (4.2g, 20 mmol), Sn powder (4.7 g, 40 mmol) and 5 mol/L hydrochloric acid (14 ml), 40 ℃ stirring for 2 hours, the reaction is completed, to remove the ethanol, add 50 ml of water residue is completely dissolved, saturated NaHCO3 solution and to pH=8, and filtering the resulting solid, after drying, dissolved in 50 ml chloroform, adding CuBr2(13.4 g, 60mmol), 60 Cstirring for 2 hours, the reaction is completed, the end of the reaction, rotary evaporated to remove chloroform, adding 50 ml saturated NaHCO3 solution, ethyl acetate (3 × 100 ml), the combined organic phase with water (50 ml) for washing and then the saturated salt water (50 ml) washing, anhydrous Na2SO4 drying, filtering, the filtrate is concentrated to obtain 5-bromo-1H-pyrrolo [2,3 - the b] pyridine the crude product, the crude product is chloroform: hexane=2:1 (volume ratio) mixed solution recrystallize to get 3.1 g of pale yellow 5-Bromo-7-azaindole pure product, yield 77.6%, melting point:176.8-177.3 ℃.
Solubility in organics
The solubility of 5-Bromo-7-azaindole in pure solvents increases with increasing temperature. Among them 5-Bromo-7-azaindole showed the best solubility in methyl acetate and the worst solubility in hexane. The maximum change in solubility of 5-Bromo-7-azaindole in DCM was observed at T = 298.15-313.15 K. The solubility of 5-Bromo-7-azaindole in DCM was found to be the most variable.
5-Bromo-7-azaindole Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +8613916485955 | Rajasthan, India | 145 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| chemmolelaboratories private limited | +undefined9491767516 | Telangana, India | 48 | 58 | Inquiry |
| Omshri Labs Pvt Ltd | +91-7977270534 +91-9833689647 | Maharashtra, India | 46 | 58 | Inquiry |
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| Manik Laboratories | +91-8121482049 +91-8121482049 | New Delhi, India | 49 | 58 | Inquiry |
| ssk bioscience pvt. ltd | +91-8106421818 +91-8106421818 | Hyderabad, India | 40 | 58 | Inquiry |
| SAMSON ORGANICS | +91-8341971897 +91-8341971897 | Hyderabad, India | 15 | 58 | Inquiry |
| chakrachem Lifesciences | +91 9902744663 | Hyderabad, India | 451 | 58 | Inquiry |
| TEADUS PHARMA PRIVATE LIMITED | +91-9740077663 +91-9740077663 | Telangana, India | 242 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Terma Medicare India Pvt.,Ltd | 58 |
| GLR Innovations | 58 |
| chemmolelaboratories private limited | 58 |
| Omshri Labs Pvt Ltd | 58 |
| ANJI BIOSCIENCES | 58 |
| Manik Laboratories | 58 |
| ssk bioscience pvt. ltd | 58 |
| SAMSON ORGANICS | 58 |
| chakrachem Lifesciences | 58 |
| TEADUS PHARMA PRIVATE LIMITED | 58 |
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