Pyridoxal 5'-phosphate monohydrate
- CAS No.
- 41468-25-1
- Chemical Name:
- Pyridoxal 5'-phosphate monohydrate
- Synonyms
- PLP;PYRIDOXAL 5-PHOSPHATE MONOHYDRATE;5-Phosphate Monohydrate;PYRIDOXAL PHOSPHATE MONOHYDRATE;Pyridoxal 5-phosphate monohydrate(PLP);(4-ForMyl-5-hydroxy-6-Methylpyridin-3-yl)Methyl dihydrogen phosphate hydrate;Plp1;ACR1;B116;AOEB116
- CBNumber:
- CB6757175
- Molecular Formula:
- C8H12NO7P
- Molecular Weight:
- 265.16
- MOL File:
- 41468-25-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/8 17:36:13
| Melting point | 140-143 °C(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Acetonitrile (Slightly), DMSO (Slightly) |
| form | Crystalline Powder |
| color | Pale yellow |
| Water Solubility | 5 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| Merck | 14,7979 |
| BRN | 234749 |
| Stability | Air Sensitive, Moisture Sensitive |
| InChI | InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2 |
| InChIKey | CEEQUQSGVRRXQI-UHFFFAOYSA-N |
| SMILES | C1(COP(=O)(O)O)=CN=C(C)C(O)=C1C=O.O |
| CAS DataBase Reference | 41468-25-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | UV1208000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
Pyridoxal 5'-phosphate monohydrate price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 82870 | Pyridoxal 5′-phosphate monohydrate ≥97.0% (NT) | 41468-25-1 | 1G | ₹3593.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 82870 | Pyridoxal 5′-phosphate monohydrate ≥97.0% (NT) | 41468-25-1 | 5G | ₹12957.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SAB2501870 | Anti-PDXP (C-terminal) antibody produced in goat affinity isolated antibody, buffered aqueous solution | 41468-25-1 | 100μG | ₹53135.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 82870 | Pyridoxal 5′-phosphate monohydrate ≥97.0% (NT) | 41468-25-1 | 25G | ₹31251.78 | 2022-06-14 | Buy |
| ALFA India | ALF-A12323-14 | Pyridoxal-5-phosphate hydrate, 98% | 41468-25-1 | 25g | ₹17675 | 2022-05-26 | Buy |
Pyridoxal 5'-phosphate monohydrate Chemical Properties,Uses,Production
Chemical Properties
Pyridoxal Phosphate Hydrate occurs as a pale yellow-white to light yellow crystalline powder.
It is slightly soluble in water, and practically insoluble in ethanol (99.5).
It dissolves in dilute hydrochloric acid and in sodium hydroxide TS.
The pH of a solution prepared by dissolving 0.1 g of Pyridoxal Phosphate Hydrate in 200 mL of water is between 3.0 and 3.5.
Pyridoxal Phosphate Hydrate is colored to light red by light.
Uses
Pyridoxal 5-phosphate (PLP) (active form of Vitamin B6) is an enzyme prosthetic group that acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into GABA; of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.
Application
Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.
Pyridoxal 5′-phosphate monohydrate has been used:
as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
as a dietary supplement to study its effects on the lethal phenotype of mutant flies.
Biosynthesis
Two distinct pathways for Pyridoxal 5′-phosphate (PLP) biosynthesis are known. 1.The 'DXP dependent' pathway is found in Escherichia coli and a few members of the γ subdivision of proteobacteria and has been extensively characterized. In this pathway deoxyxylulose 5-phosphate (DXP) is condensed with 3-hydroxy-1-aminoacetone phosphate to give PNP. PNP is oxidized to PLP by PdxH. The DXP dependent pathway is not widely distributed and is surprisingly complex requiring seven enzymes (GapB, PdxB, PdxF (SerC), PdxA, DXS, PdxJ and PdxH). This pathway was the first discovered and it has been extensively reviewed. 2. The second pathway uses Pdx1 and Pdx2 to catalyze the condensation of d-ribose 5-phosphate (R5P), glutamine and glyceraldehyde 3-phosphate to form PLP. The mechanistic and structural characterization of both pathways is at an advanced stage.
General Description
Pyridoxal 5'-phosphate (PLP, vitamin B6) is an essential cofactor in all living systems. It is one of the most versatile cofactors and participates in transamination, decarboxylation, racemization, Cα-Cβ cleavage and α-β elimination reactions. PLP plays an important role in amino acid and carbohydrate metabolism and has been implicated in singlet oxygen resistance. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. By inhibiting AGE formation and working as a coenzyme in chemical reactions, pyridoxal 5’-phosphate can support healthy nerve, eye, cardiovascular and kidney function.
Biological Activity
Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.
Pyridoxal 5'-phosphate monohydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Panvo Organics Pvt Ltd | +91 9789806833 +91 9444351711 | Tamil Nadu, India | 23 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Chemkart | 08048608430 | Mumbai, India | 37 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Otto Chemie Pvt Ltd | 58 |
| Panvo Organics Pvt Ltd | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Central Drug House(P) Ltd. | 58 |
| Triveni chemicals | 58 |
| Chemkart | 58 |
Related Qustion
- Q:What does Pyridoxal 5'-phosphate monohydrate do?
- A:Pyridoxal-5'-phosphate monohydrate is a metabolite of vitamin B6. It has the ability to modify lysine and valine residues in p....
- Nov 20，2023
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