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Asiaticoside

Asiaticoside Structure
CAS No.
16830-15-2
Chemical Name:
Asiaticoside
Synonyms
Asiaticosides;asiaticosid;MADECASSOL;dermatologico;blastoestimulina;2-alpha,3-beta,23-trihydroxy-urs-12-en-28-oicacio-6-deoxy-alpha-l-mannopy;Ba-2742;CENTELASE;MADECASOL;Meal snow
CBNumber:
CB7109339
Molecular Formula:
C48H78O19
Molecular Weight:
959.12
MOL File:
16830-15-2.mol
Modify Date:
2024/11/19 15:53:33
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Asiaticoside Properties

Melting point 235-238°C
alpha D20 -14° (alc)
Boiling point 1017.5±65.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
vapor pressure 0.001Pa at 160℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly)
pka 12.50±0.70(Predicted)
form Solid
color Crystals
Water Solubility 99mg/L
InChIKey WYQVAPGDARQUBT-KRQXBQLUNA-N
LogP 0.44 at 22℃
CAS DataBase Reference 16830-15-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Safety Statements  24/25
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  YU9625000
F  1-10
HS Code  29389090

Asiaticoside price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 43191 Asiaticoside analytical standard 16830-15-2 1MG ₹4860.43 2022-06-14 Buy
Sigma-Aldrich(India) 43191 Asiaticoside analytical standard 16830-15-2 5MG ₹18294.25 2022-06-14 Buy
Product number Packaging Price Buy
43191 1MG ₹4860.43 Buy
43191 5MG ₹18294.25 Buy

Asiaticoside Chemical Properties,Uses,Production

Description

Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat a variety of ailments including dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. In various wound healing models, topical application (0.2-0.4%), injection (1 mg), or ingestion (1 mg/kg) of asiaticoside has been shown to increase hydroxyproline content, improve tensile strength, increase collagen synthesis and remodeling of the collagen matrix, promote epithelialization, stimulate glycosaminoglycan synthesis, and elevate antioxidant levels.

Chemical Properties

White powder

Uses

Asiatic Acid is a terpenoid saponin component isolated from Centella asiatica with antioxidant and anti-inflammatory activities. Asiaticoside has been shown to possess strong wound-healing properties and reduces scar formation.

Biological Activity

Asiaticoside, a triterpenoid compound from Centella asiatica, has been shown to have anti-inflammatory, anti-renal fibrosis and tissue repair promoting effects. Asiaticoside has been shown through ex vivo and in vivo studies to reduce blood urea nitrogen (BUN) and serum creatinine (Scr) levels in a renal ischemia-reperfusion injury (IRI) model [1]. Meanwhile, Asiaticoside decreased the secretion of IL-6, IL-1β, and TNF-α, but increased the secretion of IL-10 using a dose-dependent manner. Treatment of Raw264.7 cells with lipopolysaccharide (LPS) induced an inflammatory response, but the LPS-induced effect was attenuated by the administration of asiaticoside. In addition, asiaticoside significantly inhibits LPS-induced expression of inducible nitric oxide synthase (iNOS) and promotes expression of the polarisation marker protein arginase 1. It is also a potential candidate for use as a dental wound healing agent with a maximum tolerated concentration of 0.25 mg/ml, and its mechanism of action may be related to increased Col1A1 gene expression [2].

Safety Profile

Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits acrid smoke and fumes. Promoteshealing of wounds.

References

[1] XINGYING ZHAO, JINGWEN ZHOU*; Elucidation of the Biosynthesis of Asiaticoside and Its Reconstitution in Yeast[J]. ACS Sustainable Chemistry & Engineering, 2024, 12 10: 4028-4040. DOI:10.1021/acssuschemeng.3c07046.
[2] W. H. SURIYAH. In Vitro Wound Healing Effect of Asiaticoside Extracted from Centella asiatica (‘Pegaga’) on Human Gingival Fibroblast Cell Line[J]. Materials Science Forum, 2021, 72 1: 224-229. DOI:10.4028/www.scientific.net/MSF.1025.224.

Asiaticoside Preparation Products And Raw materials

Raw materials

PETROLEUM ETHER

Preparation Products

Asiaticoside Suppliers

Global( 503)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Natural Remedies Pvt Ltd +91 (80) 4020-9999 New Delhi, India 110 50 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6514 58 Inquiry
Phytocompounds 91-80-40209999 Karnataka, India 35 58 Inquiry
Herb Artizan Private Limited 08048372815Ext 272 Karnataka, India 3 58 Inquiry
Maysar Herbals 08047629700 Haryana, India 19 58 Inquiry
Alkaloids Corporation +(91)33-22485464 Kolkata, India 14 58 Inquiry
Shaanxi LonierHerb Bio Technology Co Ltd +86-86-+86-86-029-87551862 +8617702909819 China 2608 58 Inquiry
BINBO BIOLOGICAL CO.,LTD +8618629063126 China 430 58 Inquiry
Supplier Advantage
Natural Remedies Pvt Ltd 50
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
SynZeal Research Pvt Ltd 58
Phytocompounds 58
Herb Artizan Private Limited 58
Maysar Herbals 58
Alkaloids Corporation 58
Shaanxi LonierHerb Bio Technology Co Ltd 58
BINBO BIOLOGICAL CO.,LTD 58

Asiaticoside Spectrum

Asiaticoside(16830-15-2)1HNMR

16830-15-2(Asiaticoside)Related Search:

Asiaticoside Kresoxim-methyl Centella asiatica extract Methyl acetate Bensulfuron methyl
Thiophanate-methyl METSULFURON METHYL Methyl salicylate Methylparaben Rotundine
Sophoricoside Ursolic acid Asiaticoside B Methyl Centella asiatica whole plant
Methyl bromide GLYCEROL MONOISOSTEARATE Hydroxy asiaticoside Madecassol
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ranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-6)-o-beta-d-glucopyranosylester CENTELASE ASIATICOSIDE MADECASOL [6-[[3,4-Dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyl-oxan-2-yl)oxy-oxan-2-yl]oxymethyl]-3,4,5-trihydroxy-oxan-2-yl] (1S,2R,4aS,6aS,6bR,9S,10R,11R,12aS,14bR)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-.alpha.-L-mannopyranosyl-(1?4)-O-.beta.-D-glucopyranosyl-(1?6)-.beta.-D-glucopyranosyl ester, (2.alpha.,3.beta.,4.alpha.)- ASIATICOSIDE(P) Gotu Kola (Centella Asiatica) (40%Asiatisides) Urs-12-en-28-oic acid,2,3,23-trihydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranos yl-(1→6)- β-D-glucopyranosyl ester, (2α,3β,4α)- O-6-Deoxy-a-L-mannopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl (2a,3b,4a)-2,3,23-trihydroxyurs-12-en-28-oate O-6-Deoxy-a-L-mannopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl ester, (2a,3b,4a)- (4R)-2α,3β,23-Trihydroxyurs-12-en-28-oic acid [6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl] ester 2α,3β,23-Trihydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester Ba-2742 Centella Asiatica(40%Asiatisides) ASIATICOSIDE hplc ASIATICOSIDE WITH HPLC Asiaticoside,Madecassol Asiaticoside Gotu Kola Extract (1S,2R,4aS,6aS,6bR,9S,10R,11R,12aS,14bR)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate BlastostiMulina EMdecassol Marticassol Asiaticoside (30 mg) Asiaticoside, froM Centella asiatica Meal snow Asiaticoside, >=98% Asiaticoside 16830-15-2 Centella asiatica extractTriterpenoid saponins Total Triterpenes of centella asiatica extract Asiaticoside(Single) (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid [(2S,3R,4S Centella asiatica Extract Asiaticoside powder Asiaticoside, 98%, from Centella asiatica (L.) Urb. Asiaticosides 10%-80% Asiaticoside CRS BRN0078195 CCRIS8995 NSC166062 Asiaticoside,90% Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α)- Asiaticoside USP/EP/BP Centella asiatica powder Asiaticoside/Centella asiatica Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α)- 2-alpha,3-beta,23-trihydroxy-urs-12-en-28-oicacio-6-deoxy-alpha-l-mannopy asiaticosid blastoestimulina dermatologico MADECASSOL Asiaticosides asiaticcoside Asiaticoside (6CI) (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate Centella Total Glucosides, CTG Asiaticoside-RM O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl (2α,3β,4α)-2,3,23-trihydroxyurs-12-en-28-oate