Madecassic acid
- CAS No.
- 18449-41-7
- Chemical Name:
- Madecassic acid
- Synonyms
- Madecasoside;MADECASSIC ACID;MADECASSIC ACID(P);Hydroxyasiatic acid;Hydroxy asiaticoside;6-Hydroxyasiatic acid;Madecassic Acid (97%);Brahmic acid 18449-41-7;6BETA-HYDROXYASIATIC ACID;Hydroxycentella glycoside
- CBNumber:
- CB7280283
- Molecular Formula:
- C30H48O6
- Molecular Weight:
- 504.71
- MOL File:
- 18449-41-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/24 17:21:45
| Melting point | 270°C (dec.) |
|---|---|
| Boiling point | 641.7±55.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Sparingly), Methanol (Slightly, Heated) |
| pka | 4.63±0.70(Predicted) |
| form | Solid |
| color | White to Pale Red |
| InChIKey | PRAUVHZJPXOEIF-MRQYELSVNA-N |
| LogP | 4.321 (est) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H410 |
| Precautionary statements | P501-P273-P270-P264-P391-P301+P310+P330-P405 |
| Hazard Codes | Xi |
| Safety Statements | 24/25 |
| HS Code | 29389090 |
Madecassic acid Chemical Properties,Uses,Production
Description
Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; ), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; ). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.
Chemical Properties
White powder
Definition
ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).
Madecassic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 318)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12456 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | China | 301 | 58 | Inquiry |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | China | 346 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8822 | 58 | Inquiry |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | China | 2995 | 58 | Inquiry |
18449-41-7(Madecassic acid)Related Search:
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(2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid
MADECASSIC ACID
Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2.alpha.,3.beta.,4.alpha.,6.beta.)-
(1S,2R,4aS,6aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy -9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,1 1,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Hydroxy asiaticoside
MADECASSIC ACID(P)
6BETA-HYDROXYASIATIC ACID
2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid
6-Hydroxyasiatic acid
Madecasoside
Madecassic acid, froM Centella asiatica
(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-Trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
(1S,2R,4aS,6aS,6bR,8R,9R,10R,11R,12aR)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,4α,6β)-
Madecassic Acid (97%)
Brahmic acid 18449-41-7
Urs-12-en-28-oic acid,2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)-
Madecassic acid, 98%, from Centella asiatica (L.) Urb.
Hydroxycentella glycoside
Madecassic acid/Madecassoide
Hydroxyasiatic acid
18449-41-7
C30H48O6
Inhibitors
Cofactor
chemical reagent
pharmaceutical intermediate
phytochemical
reference standards from Chinese medicinal herbs (TCM).
standardized herbal extract
Miscellaneous Natural Products
The group of Asiaticoside