trapoxin A

CAS No.: 133155-89-2

Chemical Name:: trapoxin A

Synonyms: RF-1023A;trapoxin A;Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-];Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl);Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];(4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone

CBNumber:: CB71316516

Molecular Formula:: C34H42N4O6

Molecular Weight:: 602.72

MOL File:: 133155-89-2.mol

Modify Date:: 2023/5/18 11:31:13

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trapoxin A Properties

storage temp.	-20°C
solubility	DMSO: soluble0.9-1.10 mg/ml, clear, colorless to faintly yellow (may be further diluted 20 fold in H2O)
form	solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3

trapoxin A price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T2580	Trapoxin A ≥98% (HPLC), from Helicoma ambiens	133155-89-2	1MG	₹21628.35	2022-06-14	Buy
Sigma-Aldrich(India)	T2580	Trapoxin A ≥98% (HPLC), from Helicoma ambiens	133155-89-2	5MG	₹70265.08	2022-06-14	Buy

Product number	Packaging	Price	Buy
T2580	1MG	₹21628.35	Buy
T2580	5MG	₹70265.08	Buy

trapoxin A Chemical Properties,Uses,Production

Description

Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. It inhibits HDAC activity in a concentration-dependent and irreversible manner. Trapoxin A inhibits proliferation of NIH3T3 cells transformed by the oncogene v-sis (sis/NIH3T3; IC₅₀ = ~200 ng/ml) and has detransformation activity, flattening sis/NIH3T3 cells when used at a concentration of 1 ng/ml. It also halts the cell cycle at the G₂ phase in 3Y1 fibroblasts when used at a concentration of 10 nM and inhibits growth of TR303 cells resistant to trichostatin A at a concentration of 50 ng/ml.

Uses

Trapoxin A has been used:

to study its effects on the inhibition of histone deacetylase 11 (HDAC11)
to study its effects on the inhibition of HDAC3 in human cell lines
to study its effects on the inhibition of HDAC6 in rat pyramidal neurons

Definition

ChEBI: A homodetic cyclic tetrapeptide constructed from L-phenylalanyl (x2), D-pipecolinyl and L-2-amino-8-oxo-9,10-epoxydecanoyl residues.

trapoxin A Preparation Products And Raw materials

Raw materials

Preparation Products

trapoxin A Suppliers

Global( 8)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
InvivoChem	13549236410	China	6755	58	Inquiry
CHEMICAL LAND21	82- 2 -783 - 8063	South Korea	6315	74	Inquiry
Riedel-de Haen AG	800 558-9160	United States	6825	87	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Sigma-Aldrich	021-61415566 800-8193336	China	51471	80	Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	China	11289	58	Inquiry

Supplier	Advantage
Aladdin Scientific	58
InvivoChem	58
CHEMICAL LAND21	74
Riedel-de Haen AG	87
Cayman Chemical Company	81
Sigma-Aldrich	80
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58

133155-89-2(trapoxin A)Related Search:

Pipecolamide Cyclen trapoxin A 2-(2-methylpiperidin-1-yl)ethanamine ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE

N-methylpiperidine-2-carboxamide N-(PIPERIDINOETHYL)ETHYLENEDIAMINE 1-ethylpiperidine-2-methylamine CHEMBRDG-BB 4015189 N-[(1-ETHYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE

ETHYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE N-[(1-PROPYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE BUTYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE BUTYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE (1-ETHYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE

(1-BUTYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE N-[(1-BUTYL-2-PIPERIDINYL)METHYL]ETHANAMINE ETHYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE

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trapoxin A (4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-] RF-1023A Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl) Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl] Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl] 133155-89-2