trapoxin A
![trapoxin A Structure](CAS/GIF/133155-89-2.gif)
- CAS No.
- 133155-89-2
- Chemical Name:
- trapoxin A
- Synonyms
- RF-1023A;trapoxin A;Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-];Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl);Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];(4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone
- CBNumber:
- CB71316516
- Molecular Formula:
- C34H42N4O6
- Molecular Weight:
- 602.72
- MOL File:
- 133155-89-2.mol
- Modify Date:
- 2023/5/18 11:31:13
trapoxin A price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | T2580 | Trapoxin A ≥98% (HPLC), from Helicoma ambiens | 133155-89-2 | 1MG | ₹21628.35 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T2580 | Trapoxin A ≥98% (HPLC), from Helicoma ambiens | 133155-89-2 | 5MG | ₹70265.08 | 2022-06-14 | Buy |
trapoxin A Chemical Properties,Uses,Production
Description
Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. It inhibits HDAC activity in a concentration-dependent and irreversible manner. Trapoxin A inhibits proliferation of NIH3T3 cells transformed by the oncogene v-sis (sis/NIH3T3; IC50 = ~200 ng/ml) and has detransformation activity, flattening sis/NIH3T3 cells when used at a concentration of 1 ng/ml. It also halts the cell cycle at the G2 phase in 3Y1 fibroblasts when used at a concentration of 10 nM and inhibits growth of TR303 cells resistant to trichostatin A at a concentration of 50 ng/ml.
Uses
Trapoxin A has been used:
- to study its effects on the inhibition of histone deacetylase 11 (HDAC11)
- to study its effects on the inhibition of HDAC3 in human cell lines
- to study its effects on the inhibition of HDAC6 in rat pyramidal neurons
Definition
ChEBI: A homodetic cyclic tetrapeptide constructed from L-phenylalanyl (x2), D-pipecolinyl and L-2-amino-8-oxo-9,10-epoxydecanoyl residues.
trapoxin A Preparation Products And Raw materials
Raw materials
Preparation Products
trapoxin A Suppliers
Global( 8)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
InvivoChem | 13549236410 | China | 6755 | 58 | Inquiry |
CHEMICAL LAND21 | 82- 2 -783 - 8063 | South Korea | 6315 | 74 | Inquiry |
Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | China | 11289 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Aladdin Scientific | 58 |
InvivoChem | 58 |
CHEMICAL LAND21 | 74 |
Riedel-de Haen AG | 87 |
Cayman Chemical Company | 81 |
Sigma-Aldrich | 80 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
133155-89-2(trapoxin A)Related Search:
Pipecolamide
Cyclen
trapoxin A
2-(2-methylpiperidin-1-yl)ethanamine
ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE
N-methylpiperidine-2-carboxamide
N-(PIPERIDINOETHYL)ETHYLENEDIAMINE
1-ethylpiperidine-2-methylamine
CHEMBRDG-BB 4015189
N-[(1-ETHYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE
chevron_left
1of4
chevron_right
trapoxin A
(4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone
Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-]
RF-1023A
Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl)
Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl]
Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl]
133155-89-2