Cyclen
- CAS No.
- 294-90-6
- Chemical Name:
- Cyclen
- Synonyms
- 1,4,7,10-TETRAAZACYCLODODECANE;1,4,7,10-Tetrazacyclododecane;Gm-D;CYCLEN;NSC 629374;Cyclen,97%;Cyclen(M-100);Cyclen, >=99%;Kryptofix 11 aza;Cyclen≥ 99% (GC)
- CBNumber:
- CB5158782
- Molecular Formula:
- C8H20N4
- Molecular Weight:
- 172.27
- MOL File:
- 294-90-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/13 17:19:14
| Melting point | 110-113 °C (lit.) |
|---|---|
| Boiling point | 292.61°C (rough estimate) |
| Density | 1.0415 (rough estimate) |
| vapor pressure | 0.004Pa at 20℃ |
| refractive index | 1.5872 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 10.53±0.20(Predicted) |
| form | Crystalline Powder |
| color | Almost white to slightly yellow |
| Water Solubility | almost transparency |
| BRN | 606114 |
| Stability | hygroscopic |
| InChIKey | QBPPRVHXOZRESW-UHFFFAOYSA-N |
| LogP | -0.63 at 20℃ |
| CAS DataBase Reference | 294-90-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H314-H410 | |||||||||
| Precautionary statements | P260-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XA5253000 | |||||||||
| F | 3-9-34 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Cyclen price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 339652 | Cyclen 97% | 294-90-6 | 250MG | ₹13087.43 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T1874 | 1,4,7,10-Tetraazacyclododecane min. 97.0 % | 294-90-6 | 1G | ₹16000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T1874 | 1,4,7,10-Tetraazacyclododecane min. 97.0 % | 294-90-6 | 5G | ₹23400 | 2022-05-26 | Buy |
| ottokemi | C 0495 | Cyclen, 99% | 294-90-6 | 1gm | ₹13203 | 2022-05-26 | Buy |
| ottokemi | C 0495 | Cyclen, 99% | 294-90-6 | 5gm | ₹19502 | 2022-05-26 | Buy |
Cyclen Chemical Properties,Uses,Production
Chemical Properties
almost white to slightly yellow crystalline powder, soluble in methanol, ethanol, dmso and other organic solvents, derived from stephania cepharantha.
Uses
Cyclen is an azamocrocycle, which can be used in the development of fluorescent nanosensors for the detection of metal ions.
Application
Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well ass other imaging) agents.
General Description
Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.
Synthesis
Some syntheses exploit the Thorpe-Ingold effect to facilitate ring-formation. Illustrative is the reaction of the deprotonated tosylamides with ditosylates:
TsN(CH2CH2NTsNa)2 + TsN(CH2CH2OTs)2 → (TsNCH2CH2)4
The resulting macrocycle can be deprotected with strong acid. Base gives the tetramine.
High dilution conditions result in a low reaction rate penalty and this disadvantage is removed in an alternative procedure starting from triethylenetetraamine and dithiooxamide to a bisamidine – also a bis(imidazoline) – followed by reduction and ring expansion with DIBAL. 
In one study cyclen is covalently bonded through a propylene molecular spacer to adenine and chelated with zinc diperchlorate. This complex is able to selectively bind uracil and uridine in a 1:2 ratio both through the adenine part and cyclen part of the molecule as evidenced by mass spectrometry.
wiki/Cyclen
Cyclen Preparation Products And Raw materials
Raw materials
1of4
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1262 | 58 | Inquiry |
| Manik Laboratories | +91-8121482049 +91-8121482049 | New Delhi, India | 49 | 58 | Inquiry |
| Molkem Chemicals | +91-917228022464 +91-7228022464 | Ahmedabad, India | 138 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1817 | 58 | Inquiry |
| STELLENCE PHARMSCIENCE PVT TLD | +91-9820778787 +91-9820778787 | Bangalore, India | 25 | 58 | Inquiry |
| TEADUS PHARMA PRIVATE LIMITED | +91-9740077663 +91-9740077663 | Telangana, India | 242 | 58 | Inquiry |
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| Noble Molecular Research | +91 9717706044 | Uttar Pradesh, India | 85 | 58 | Inquiry |
| Dr. Silviu Pharmachem Pvt., Ltd. | +91-8390608382 +91-8390608382 | Mumbai, India | 248 | 58 | Inquiry |
| RVR Labs Pvt Ltd | +91-9912882943 +91-9912882943 | Hyderabad, India | 53 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| Manik Laboratories | 58 |
| Molkem Chemicals | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| STELLENCE PHARMSCIENCE PVT TLD | 58 |
| TEADUS PHARMA PRIVATE LIMITED | 58 |
| CNS CHEMICALS | 58 |
| Noble Molecular Research | 58 |
| Dr. Silviu Pharmachem Pvt., Ltd. | 58 |
| RVR Labs Pvt Ltd | 58 |