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trapoxin A

trapoxin A Structure
  • ₹21628.35 - ₹70265.08
  • Product name: trapoxin A
  • CAS: 133155-89-2
  • MF: C34H42N4O6
  • MW: 602.72
  • EINECS:
  • MDL Number:MFCD00900598
  • Synonyms:trapoxin A;(4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone;Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-];RF-1023A;Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl);Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl]
Price2 Properties Safety Information Description
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberT2580
  • Product descriptionTrapoxin A ≥98% (HPLC), from Helicoma ambiens
  • Packaging1MG
  • Price₹21628.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT2580
  • Product descriptionTrapoxin A ≥98% (HPLC), from Helicoma ambiens
  • Packaging5MG
  • Price₹70265.08
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T2580 Trapoxin A ≥98% (HPLC), from Helicoma ambiens 1MG ₹21628.35 2022-06-14 Buy
Sigma-Aldrich(India) T2580 Trapoxin A ≥98% (HPLC), from Helicoma ambiens 5MG ₹70265.08 2022-06-14 Buy

Properties

storage temp. :-20°C
solubility :DMSO: soluble0.9-1.10 mg/ml, clear, colorless to faintly yellow (may be further diluted 20 fold in H2O)
form :solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Trapoxin A is a cyclotetrapeptide and an HDAC (histone deacetylase) inhibitor. Trapoxin increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin irreversibly inhibits HDAC activity in crude cell lysates and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.

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Suppliers and manufacturers

Aladdin Scientific CHEMICAL LAND21 Sigma-Aldrich Riedel-de Haen AG Cayman Chemical Company InvivoChem ChemeGen(Shanghai) Biotechnology Co.,Ltd.