1,2,3,4-Tetrahydroquinoline
- CAS No.
- 635-46-1
- Chemical Name:
- 1,2,3,4-Tetrahydroquinoline
- Synonyms
- Tetrahydroquinoline;200g;Kusol;200G/1KG/5KG;AURORA KA-684;1-AZATETRALIN;AKOS BBS-00003596;1,2,3,4-Tetrahydroqu;1,2,3,4-Hydroquinoline;Py-Tetrahydroquinoline
- CBNumber:
- CB7286982
- Molecular Formula:
- C9H11N
- Molecular Weight:
- 133.19
- MOL File:
- 635-46-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/28 13:43:08
| Melting point | 9-14 °C (lit.) |
|---|---|
| Boiling point | 113-117 °C/10 mmHg (lit.) 249 °C (lit.) |
| Density | 1.061 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 213 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| pka | 5.09±0.20(Predicted) |
| color | Clear pale yellow to yellow |
| Odor | at 1.00 % in dipropylene glycol. honey civet animal phenolic |
| PH | 10-11 (111g/l, H2O, 20℃)(as an emulsion) |
| Odor Type | animal |
| Water Solubility | <1 g/L (20 ºC) |
| FreezingPoint | 11.0 to 20.0 ℃ |
| BRN | 116149 |
| LogP | 2.290 |
| CAS DataBase Reference | 635-46-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Quinoline, 1,2,3,4-tetrahydro-(635-46-1) |
| EPA Substance Registry System | 1,2,3,4-Tetrahydroquinoline (635-46-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H412 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P310-P405-P501 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-45 | |||||||||
| Safety Statements | 26-36/37-36-45-53 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29334990 | |||||||||
| NFPA 704 |
|
1,2,3,4-Tetrahydroquinoline price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T15504 | 1,2,3,4-Tetrahydroquinoline 98% | 635-46-1 | 5G | ₹2457.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T15504 | 1,2,3,4-Tetrahydroquinoline 98% | 635-46-1 | 100G | ₹3832.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T15504 | 1,2,3,4-Tetrahydroquinoline 98% | 635-46-1 | 500G | ₹13206.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 87350 | 1,2,3,4-Tetrahydroquinoline purum, ≥96.0% (GC) | 635-46-1 | 100ML | ₹4081.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 87350 | 1,2,3,4-Tetrahydroquinoline purum, ≥96.0% (GC) | 635-46-1 | 500ML | ₹13834.35 | 2022-06-14 | Buy |
1,2,3,4-Tetrahydroquinoline Chemical Properties,Uses,Production
Chemical Properties
Clear pale yellow to yellow liquid. It is easily oxidized in air and may acquire a pale amber colour if exposed to air and daylight. Solidifies in the cold.
Uses
1,2,3,4-Tetrahydroquinoline is a reagent used in the synthesis of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamides displaying fungicidal activity.
Definition
ChEBI: A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.
Synthesis
1,2,3,4-Tetrahydroquinoline is synthesised using quinoline N-oxide as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: In a 1.5 mL reaction vial, B(C6F5)3 (0.025 mmol, 5.0 mol %) was dissolved in chloroform (0.60 mL), towhich diethylsilane (1.75 mmol, 3.5 equiv) was added. After shaking briefly, quinolines (1a-p, 0.50 mmol, 1.0equiv) was subsequently added to the above catalyst solution under argon atmosphere. The reaction mixturewas stirred at 25-65 oC for 6-24 h for the reaction of 1a-h, and at 25-100 oC for 2-24 h for the reaction of 1i-p,then allowed to cool down to room temperature and concentrated under reduced pressure to give the crudeproduct. This reaction mixture was then treated with 0.25 N HCl ethereal solution (7 mL) and stirred at roomtemperature for 1 h to give the solid residue, which was subsequently washed with ether. The solid residue wasthen dissolved or suspended in MeOH (1.0 mL) and neutralized with Na2CO3·H2O (0.5 g) at 0 oC. After stirringfor 2 h, MeOH was removed under reduced pressure, and the neutralized reaction residue was dissolved inCH2Cl2 and washed with brine (5 mL) and water (5 mL). The crude product was then obtained from the organicphase of CH2Cl2 solution and finally purified by column chromatography on silica gel to give 2a-h(EtOAc/Hexane = 1/9) and 2i-p (EtOAc/Hexane = 3/7).
1,2,3,4-Tetrahydroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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