Sulfadimethoxine
- CAS No.
- 122-11-2
- Chemical Name:
- Sulfadimethoxine
- Synonyms
- SULPHADIMETHOXINE;Sulfadimethoxine base;sulfadimethoxin;symbio;sulfadimetoxin;abcid;albon;fuxal;sudine;Dosmin
- CBNumber:
- CB7333026
- Molecular Formula:
- C12H14N4O4S
- Molecular Weight:
- 310.33
- MOL File:
- 122-11-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/17 18:45:41
| Melting point | 200 °C |
|---|---|
| Boiling point | 265.5°C (rough estimate) |
| Density | 1.4006 (rough estimate) |
| refractive index | 1.6270 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | NH4OH 1 M: 50 mg/mL, clear, faintly yellow |
| form | Solid |
| pka | pKa 5.94(H2O t = 25.0±0.5 I = 0.2) (Uncertain) |
| color | White to Off-White |
| Water Solubility | 46.3mg/L(37 ºC) |
| Merck | 14,8905 |
| BRN | 306856 |
| InChI | InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16) |
| InChIKey | ZZORFUFYDOWNEF-UHFFFAOYSA-N |
| SMILES | C1(S(NC2C=C(OC)N=C(OC)N=2)(=O)=O)=CC=C(N)C=C1 |
| CAS DataBase Reference | 122-11-2(CAS DataBase Reference) |
| EPA Substance Registry System | Sulfadimethoxine (122-11-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-43 | |||||||||
| Safety Statements | 26-36/37-24/25-23 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | WO9030000 | |||||||||
| F | 8 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 orally in mice: >10 g/kg (Seki) | |||||||||
| NFPA 704 |
|
Sulfadimethoxine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S7007 | Sulfadimethoxine 98.0 - 102.0% | 122-11-2 | 10G | ₹8822.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S7007 | Sulfadimethoxine 98.0 - 102.0% | 122-11-2 | 25G | ₹16962.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S7007 | Sulfadimethoxine 98.0 - 102.0% | 122-11-2 | 100G | ₹33276.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1448 | Sulfadimethoxine Pharmaceutical Secondary Standard; Certified Reference Material | 122-11-2 | 500MG | ₹9201.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46794 | Sulfadimethoxine VETRANAL?, analytical standard | 122-11-2 | 250MG | ₹5315.08 | 2022-06-14 | Buy |
Sulfadimethoxine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Definition
ChEBI: A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
Pharmaceutical Applications
2,4-Dimethoxy-6-sulfanilamido-1,3-diazine. A rapidly absorbed compound with a long half-life (38–40 h) and a high degree of protein binding (98%). Renal clearance is very slow, and daily dosage maintains adequate plasma levels.
Mechanism of action
The mechanism of action of sulfadimethoxine centres on its ability to inhibit bacterial folic acid synthesis. Folic acid, or folate, is essential for synthesising nucleotides, which are the building blocks of DNA. Sulfadimethoxine acts as a competitive inhibitor of the enzyme dihydropteroate synthase (DHPS). DHPS is crucial for converting para-aminobenzoic acid (PABA) into dihydropteroate, a precursor in folate synthesis. By inhibiting DHPS, sulfadimethoxine prevents the conversion of PABA to dihydropteroate, thereby halting the production of folic acid. Without folic acid, bacteria cannot synthesize the nucleotides necessary for DNA replication, resulting in bacteriostasis – the inhibition of bacterial growth and multiplication. This action is particularly effective against rapidly dividing bacterial cells, making sulfadimethoxine a potent antibacterial agent.
Side effects
Common but usually not serious side effects include: Reduced appetite, vomiting, loose stools (diarrhea).
Side effects that may be serious orindicate a serious problem:
Dry eye syndrome (keratoconjunctivitis sicca; KCS). Before your dog takes this drug, your veterinarian will wantto measure your dog’s tear production. Signs of dry eye include redness or discharge from the eyes or increased blinking. Difficulty urinating or straining to urinate; blood in urine.
Skin conditions: Sores, skin that appears to be burned, severe itching, loss of fur.
Increased thirst and urination.
Swelling of face.
Lack of energy or appetite, tiredness, fever.
Difficulty walking. Yellowing of the gums or whites of the eyes (jaundice).
Safety Profile
Moderately toxic by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Sulfadimethoxine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Valens Molecules | +91-040-23417926 +91-4023417926 | Hyderabad, India | 10 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6202 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5868 | 58 | Inquiry |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | China | 255 | 58 | Inquiry |
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