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Silver sulfadiazine

Silver sulfadiazine Structure
CAS No.
22199-08-2
Chemical Name:
Silver sulfadiazine
Synonyms
SILVER SULPHADIAZINE;silvadene;SULFADIAZINE SILVER;SILVER(I) SULFADIAZINE;SD-Ag;geben;Dermazin;Nsc625324;dermazine;flamazine
CBNumber:
CB4744940
Molecular Formula:
C10H9AgN4O2S
Molecular Weight:
357.14
MOL File:
22199-08-2.mol
MSDS File:
SDS
Modify Date:
2024/7/24 17:31:20

Silver sulfadiazine Properties

Melting point 285 °C (dec.)(lit.)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly)
form powder
color White to Off-White
Merck 14,8903
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey UEJSSZHHYBHCEL-UHFFFAOYSA-N
CAS DataBase Reference 22199-08-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  WP1950000
HazardClass  IRRITANT
HS Code  2935904000
NFPA 704
0
2 0

Silver sulfadiazine price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 481181 Silver(I) sulfadiazine 98% 22199-08-2 5G ₹4983.9 2022-06-14 Buy
Sigma-Aldrich(India) PHR2654 Silver Sulfadiazine Pharmaceutical Secondary Standard; Certified Reference Material 22199-08-2 500MG ₹20934.6 2022-06-14 Buy
Sigma-Aldrich(India) 481181 Silver(I) sulfadiazine 98% 22199-08-2 25G ₹19302.9 2022-06-14 Buy
TCI Chemicals (India) S0595 Silver Sulfadiazine 22199-08-2 5G ₹4500 2022-05-26 Buy
TCI Chemicals (India) S0595 Silver Sulfadiazine 22199-08-2 25G ₹13600 2022-05-26 Buy
Product number Packaging Price Buy
481181 5G ₹4983.9 Buy
PHR2654 500MG ₹20934.6 Buy
481181 25G ₹19302.9 Buy
S0595 5G ₹4500 Buy
S0595 25G ₹13600 Buy

Silver sulfadiazine Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.

Indications

Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell wall. It is used primarily as an adjunct in the prevention and treatment of wound sepsis in patients with second- and third-degree burns and for wound care of chronic ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those sensitive to silver nitrate but resistant to sulfadiazine, have shown good response to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance, and does not cause systemic acidosis. Some patients note a stinging sensation on application, and because this compound can be absorbed, systemic sulfonamide reactions similar to those caused by sulfonamides may occur.

Pharmaceutical Applications

Silver sulfadiazine is extremely insoluble. In addition to the usual activity of sulfonamides it exhibits activity – almost certainly attributable to the silver component – against Ps. aeruginosa and some fungi.
It is variably absorbed after topical application depending on the integrity of the skin. Toxic concentrations may be achieved in patients with extensive burns. It is used topically, mainly for burns, pressure sores and leg ulcers. Central venous catheters impregnated with chlorhexidine and silver sulfadiazine have been developed to reduce bacterial colonization. Other suggested uses include the prevention of infection in skin graft donor sites and cord care in newborn infants.

Clinical Use

The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.

Silver sulfadiazine Preparation Products And Raw materials

Raw materials

Preparation Products

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silver (4-aminophenyl)sulfonyl-pyrimidin-2-yl-azanide SILVER SULFADIAZINE SULPHADIAZINE-AG 4-amino-n-(2-pyrimidinyl)benzenesulfonamidesilversalt 4-amino-n-2-pyrimidinylbenzenesulfonamide monosilver salt (4-amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver [4-Amino-N-(2-pyrimidinyl-kN1)benzenesulfonamidato-kO]silver 4-Amino-N-2-pyrimidinylbenzenesulfonamide Silver Complex Dermazin Flammazine Silver, 4-amino-N-(2-pyrimidinyl-.kappa.N1)benzenesulfonamidato-.kappa.O- SILVERSULFADIAZINE,MICRONIZED SILVERSULFADIAZINE,MICRONIZED,USP sulfadiazine silver,SD-Ag Sulfadiazine,Siliver salt 4-Amino-N-2-pyrimidinylbenzenesulfonamide monosilver(1+) salt Sulfadiazine sailver salt Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex Nsc625324 Silver,(4-amino-N-2-pyrimidinylbenzenesulfonamidato-nn,o1)- Sulfadiazine silversilvadene Silver Sulfdiazine SD-Ag Silver Sulfadiazine (200 mg) 3-(4-aMinophenyl)-3-oxo-1H,4H-2$l^{3},3$l^{6},4,5,9000000$l^{5},1-pyriMido[2,1-d]1$l^{3}-oxa-2$l^{6}-thia-3,5$l^{5}-diaza-6-argentacyclohexan-1-yliuM-4-id-9-yl SILVER(I) SULFADIAZINE 98% Silver suifadiazine Silver,[4-aMino-N-(2-pyriMidinyl-kN1)benzenesulfonaMidato-kO]- 4-amino-n-2-pyrimidinyl-benzenesulfonamidmonosilver(1+)salt dermazine flamazine geben n(sup1)-2-pyrimidinyl-sulfanilamidmonosilver(1+)salt sulfadiazinesilversalt (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide Sulfadiazine silver Sulfadiazine Silver Salt SD-Ag silver(1+) sulfadiazinate silver 4-amino-N-(2-pyrimidinyl)benzenesulfonamide silver sulfadiazine powder Silver(1+) [(4-aminophenyl)sulfonyl](2-pyrimidinyl)azanide SilverSulfadiazine> Sulfadiazine Silver RS Silver sulfadiazine USP/EP/BP Silver(I) ((4-Aminophenyl)sulfonyl)(pyrimidin-2-yl)amide Silver Sulfadiazine ExiPlus, Multi-Compendial, 98% Silver Sulfadiazine (1612608) SILVER(I) SULFADIAZINE SILVER SULPHADIAZINE SULFADIAZINE SILVER silvadene SILVER SULPHADIAIZINE Silver Sulfadiazine, ≥ 98.0% SuIfadiazine Silver Silvadene|||Dermazin|||Flamazine 22199-08-2 722199-08-2 1715998-31-4 C10H9AgN4O2S