Silver sulfadiazine
![Silver sulfadiazine Structure](CAS/GIF/22199-08-2.gif)
- CAS No.
- 22199-08-2
- Chemical Name:
- Silver sulfadiazine
- Synonyms
- SILVER SULPHADIAZINE;silvadene;SULFADIAZINE SILVER;SILVER(I) SULFADIAZINE;SD-Ag;geben;Dermazin;Nsc625324;dermazine;flamazine
- CBNumber:
- CB4744940
- Molecular Formula:
- C10H9AgN4O2S
- Molecular Weight:
- 357.14
- MOL File:
- 22199-08-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 17:31:20
Melting point | 285 °C (dec.)(lit.) |
---|---|
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
form | powder |
color | White to Off-White |
Merck | 14,8903 |
Stability | Stable. Incompatible with strong oxidizing agents. |
InChIKey | UEJSSZHHYBHCEL-UHFFFAOYSA-N |
CAS DataBase Reference | 22199-08-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | WP1950000 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 2935904000 | |||||||||
NFPA 704 |
|
Silver sulfadiazine price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 481181 | Silver(I) sulfadiazine 98% | 22199-08-2 | 5G | ₹4983.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR2654 | Silver Sulfadiazine Pharmaceutical Secondary Standard; Certified Reference Material | 22199-08-2 | 500MG | ₹20934.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 481181 | Silver(I) sulfadiazine 98% | 22199-08-2 | 25G | ₹19302.9 | 2022-06-14 | Buy |
TCI Chemicals (India) | S0595 | Silver Sulfadiazine | 22199-08-2 | 5G | ₹4500 | 2022-05-26 | Buy |
TCI Chemicals (India) | S0595 | Silver Sulfadiazine | 22199-08-2 | 25G | ₹13600 | 2022-05-26 | Buy |
Silver sulfadiazine Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.
Indications
Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial
properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell
wall. It is used primarily as an adjunct in the prevention and treatment of wound
sepsis in patients with second- and third-degree burns and for wound care of chronic
ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as
well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those
sensitive to silver nitrate but resistant to sulfadiazine, have shown good response
to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance,
and does not cause systemic acidosis. Some patients note a stinging sensation on
application, and because this compound can be absorbed, systemic sulfonamide
reactions similar to those caused by sulfonamides may occur.
Pharmaceutical Applications
Silver sulfadiazine is extremely insoluble. In addition to the
usual activity of sulfonamides it exhibits activity – almost certainly
attributable to the silver component – against Ps. aeruginosa
and some fungi.
It is variably absorbed after topical application depending
on the integrity of the skin. Toxic concentrations may
be achieved in patients with extensive burns. It is used topically,
mainly for burns, pressure sores and leg ulcers. Central
venous catheters impregnated with chlorhexidine and silver
sulfadiazine have been developed to reduce bacterial colonization.
Other suggested uses include the prevention of
infection in skin graft donor sites and cord care in newborn
infants.
Clinical Use
The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.
Silver sulfadiazine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Evans Fine Chem | +91-9821340302 +91-9821340302 | Maharashtra, India | 286 | 58 | Inquiry |
Dhara Industries | +91-9322395199 +91-9322395199 | Mumbai, India | 190 | 58 | Inquiry |
India Phosphate | +91-9993319656 +91-9993319656 | Madhya Pradesh, India | 61 | 58 | Inquiry |
JPN Pharma Pvt Ltd | +919833233531 | Maharashtra, India | 33 | 58 | Inquiry |
Macsen Labs | +91-7296866111 +91-9309241616 | Rajasthan, India | 11 | 58 | Inquiry |
Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
Anuja Healthcare Ltd | +91-6239597015 +91-9815004047 | Punjab, India | 26 | 58 | Inquiry |
Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
S Kant Healthcare Ltd | +91-2266227575 +91-2266227575 | New Delhi, India | 10 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Evans Fine Chem | 58 |
Dhara Industries | 58 |
India Phosphate | 58 |
JPN Pharma Pvt Ltd | 58 |
Macsen Labs | 58 |
Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
Anuja Healthcare Ltd | 58 |
Ralington Pharma | 58 |
Chempifine Chemicals | 58 |
S Kant Healthcare Ltd | 58 |
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