Dimethyl methoxymethylenemalonate
- CAS No.
- 22398-14-7
- Chemical Name:
- Dimethyl methoxymethylenemalonate
- Synonyms
- DiMethyl 2-(MethoxyMethylene)Malonate;MMMM;Dimethyl 2-(methoxymethylene);Dimethylmethoxymethylenmalonat;DIMETHYL METHOXYMETHYLENEMALONATE;DimethylMethoxymethylenemalonate>Dimethyl methoxymethylenemalonate, 98+%;thyl 2-(methoxymethylidene)propanedioate;imethyl2-(methoxymethylidene)propanedioate;METHOXYMETHYLENEMALONIC ACID DIMETHYL ESTER
- CBNumber:
- CB7686827
- Molecular Formula:
- C7H10O5
- Molecular Weight:
- 174.15
- MOL File:
- 22398-14-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/23 10:11:41
| Melting point | 40-44 °C |
|---|---|
| Boiling point | 98 °C (0.5 mmHg) |
| Density | 1.2311 (rough estimate) |
| refractive index | 1.4390 (estimate) |
| Flash point | 158 °C |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystalline Solid |
| color | White |
| InChI | InChI=1S/C7H10O5/c1-10-4-5(6(8)11-2)7(9)12-3/h4H,1-3H3 |
| InChIKey | RHFZTBSULNJWEI-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)/C(=C\OC)/C(OC)=O |
| CAS DataBase Reference | 22398-14-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P284-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 43-36/38-22 | |||||||||
| Safety Statements | 37/39-26-24 | |||||||||
| HS Code | 29171990 | |||||||||
| NFPA 704 |
|
Dimethyl methoxymethylenemalonate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ALFA India | ALF-B23803-30 | Dimethyl methoxymethylenemalonate, 98+% | 22398-14-7 | 250g | ₹33489 | 2022-05-26 | Buy |
| ALFA India | ALF-B23803-18 | Dimethyl methoxymethylenemalonate, 98+% | 22398-14-7 | 50g | ₹13444 | 2022-05-26 | Buy |
| ALFA India | ALF-B23803-09 | Dimethyl methoxymethylenemalonate, 98+% | 22398-14-7 | 10g | ₹4069 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M1207 | Dimethyl Methoxymethylenemalonate min. 98.0 % | 22398-14-7 | 500G | ₹13700 | 2022-05-26 | Buy |
Dimethyl methoxymethylenemalonate Chemical Properties,Uses,Production
Chemical Properties
white crystalline solid
Uses
Dimethyl 2-(Methoxymethylene)malonate is a useful synthetic intermediate. It is used in preparation of (phenoxyethoxy)quinolones with antimalarial activities. It is also a reagent used in the synthesis of bicyclic pyridones prepn. as oral selective CB2 agonists with anti-pruritic activity.
Synthesis
264.2 g (2.0 mol) of dimethyl malonate, 637 g (6 mol) of trimethyl orthoformate and 20.4 g (0.2 mol) of acetic anhydride containing 2 g of H2 SO4 -activated bentonite were initially introduced into a reaction flask provided with a stirrer, thermometer, dropping funnel, column and reflux condensor, and the mixture was heated to boiling. 40.8 g (0.4 mol) of acetic anhydride was continuously metered for6 hours. The low boiling component formed was distilled off at a head temperature of 62° to 67° C. The bottom temperature increased slowly from 109° to 133° C. After 8 hours; the excess orthoester was distilled off at reduced pressure. 40.8 g (0.4 mol) of acetic anhydride was added to the remaining reaction mixture, and the mixture was heated at 140° C. for 2 hours. The catalyst was filtered off, and the crude product was distilled in vacuo. 330.4 g of dimethyl methoxymethylenemalonate (98% pure), having a melting point of 44° to 46° C., were obtained at 0.5 mbar and a head temperature of 110° C.
Dimethyl methoxymethylenemalonate Preparation Products And Raw materials
Raw materials
Preparation Products
Dimethyl methoxymethylenemalonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| DSHare Pharmaceutical Science Technology Co.Ltd. | +8613962878782 | China | 42 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | China | 1080 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29820 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | China | 8836 | 58 | Inquiry |
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