ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >SD-208
SD-208
- CAS No.
- 627536-09-8
- Chemical Name:
- SD-208
- Synonyms
- SD-208;SCI 208;CS-2295;SD-208 10MG;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;TGF-β RI Kinase Inhibitor V;TGF-β RI Kinase Inhibitor V;SD-208;SD 208; SD208; SCI 208
- CBNumber:
- CB7837155
- Molecular Formula:
- C17H10ClFN6
- Molecular Weight:
- 352.75
- MOL File:
- 627536-09-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/17 16:00:36
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SD-208 Chemical Properties,Uses,Production
Uses
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
Biological Activity
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biochem/physiol Actions
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
SD-208 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 118)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32951 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39894 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32080 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30241 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22883 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10473 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6391 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
627536-09-8(SD-208)Related Search:
SD-208
2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine
SCI 208
2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
TGF-β RI Kinase Inhibitor V
SD-208;SD 208; SD208; SCI 208
SD-208 10MG
CS-2295
SD-208 (SD 208
SD 208;SD208;TGF-Β RI KINASE INHIBITOR V
ALK5 Inhibitor V
SD-208 USP/EP/BP
SD-208,inhibit,Transforming growth factor beta receptors,TGF-β Receptor,Inhibitor,SD 208
TGF-β RI Kinase Inhibitor V
627536-09-8
C17H10ClFN6
Inhibitors
Smad
TGF-beta