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A 205804

A 205804 Structure
CAS No.
251992-66-2
Chemical Name:
A 205804
Synonyms
CS-635;A 205804;A-205804;A 205804;A 205804 USP/EP/BP;A205804;A 205804;A-205804;IKK-16 (IKK Inhibitor VII);4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide;Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-;4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...
CBNumber:
CB7838925
Molecular Formula:
C15H12N2OS2
Molecular Weight:
300.4
MOL File:
251992-66-2.mol
Modify Date:
2023/6/30 15:45:59

A 205804 Properties

Melting point 198-199℃
Boiling point 581.3±45.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility ≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka 15.12±0.30(Predicted)
form powder to crystal
color White to Orange to Green

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934.99.9001
NFPA 704
0
2 0

A 205804 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) T3498 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide 251992-66-2 25MG ₹9800 2022-05-26 Buy
TCI Chemicals (India) T3498 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide 251992-66-2 100MG ₹17500 2022-05-26 Buy
Product number Packaging Price Buy
T3498 25MG ₹9800 Buy
T3498 100MG ₹17500 Buy

A 205804 Chemical Properties,Uses,Production

Description

A-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-α (IC50s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC50 > 1,000 nM).

Uses

4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide is a reagent used in the preparation of selective inhibitors of cell adhesion molecule expression in human endothelial cells.

Biological Activity

Selective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

A 205804 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 86)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 23499 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418684 +8618949823763 China 25363 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry

A 205804 Spectrum

A 205804 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide CS-635 A205804;A 205804;A-205804 A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide 4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]- 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide A-205804 IKK-16 (IKK Inhibitor VII) A-205804;A 205804 A 205804 USP/EP/BP 4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam... Inhibitor,molecules,Adhesion,ICAM-1,A205804,E-selectin,A-205804,Integrin,A 205804,inhibit 251992-66-2 Inhibitors