ChemicalBook > Product Catalog >API >Antineoplastic agents >Antimetabolites, Antineoplastic >Raltitrexed
Raltitrexed
- CAS No.
- 112887-68-0
- Chemical Name:
- Raltitrexed
- Synonyms
- Tomudex;TDX;D1694;CS-664;ZD-1694;Retitrose;ZEN-D-1694;ICI-D-1694;Raltirexed;Raltitrexe
- CBNumber:
- CB1222070
- Molecular Formula:
- C21H22N4O6S
- Molecular Weight:
- 458.49
- MOL File:
- 112887-68-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/12 21:57:18
| Melting point | 176-1800C |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: ≥10mg/mL |
| form | solid |
| pka | 3.50±0.10(Predicted) |
| color | off-white to light yellow |
| InChIKey | IVTVGDXNLFLDRM-HNNXBMFYSA-N |
| CAS DataBase Reference | 112887-68-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Symbol(GHS) | GHS06,GHS08 |
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| Signal word | Danger | |||||||||
| Signal word | Danger | |||||||||
| Hazard statements | H300-H360 | |||||||||
| Hazard statements | H300-H360 | |||||||||
| Precautionary statements | P201-P301+P310+P330 | |||||||||
| Precautionary statements | P201-P301+P310+P330 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/38-25-61 | |||||||||
| Safety Statements | 26-37/39-45-53 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 2934.99.4700 | |||||||||
| NFPA 704 |
|
Raltitrexed price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R9156 | Raltitrexed ≥98% (HPLC), solid | 112887-68-0 | 10MG | ₹14473.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R9156 | Raltitrexed ≥98% (HPLC), solid | 112887-68-0 | 50MG | ₹58357.58 | 2022-06-14 | Buy |
| TCI Chemicals (India) | R0208 | Raltitrexed | 112887-68-0 | 50MG | ₹6500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | R0208 | Raltitrexed | 112887-68-0 | 250MG | ₹17200 | 2022-05-26 | Buy |
Raltitrexed Chemical Properties,Uses,Production
Description
Tomudex was launched in Ireland, France, Luxembourg and the UK for advanced colorectal cancer and it was prepared in a convergent manner (6 steps) from diethyl L-glutamate and 6-bromomethyi-2-methyl-quinazolin4(3H)-one. Tomudex is a highly selective inhibitor of thymidylate synthase (TS), the key enzyme in the biochemical conversion of dUMP to dTMP. It enters the cell via the reduced folatefmethotrexate cell membrane carrier and is converted to the polyglutamate species by folylpolyglutamate synthase within 4h where it then binds to the folate substrate site of TS. Clinically, it had a 29% response rate in patients with advanced colorectal cancer. It is water soluble, can be administered as a single dose every three weeks and had no hepto- or nephrotoxicity.
Chemical Properties
Yellow Crystalline Powder
Uses
Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic
Raltitrexed Preparation Products And Raw materials
Global( 353)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
112887-68-0(Raltitrexed)Related Search:
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RALTITREXED
(s)-2-[(1-{5-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid
ICI-D-1694
N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid
ZD-1694
L-Glutamic acid, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-
(S)-2-(5-(METHYL((2-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)METHYL)AMINO)THIOPHENE-2-CARBOXAMIDO)PENTANEDIOIC ACID
4-nitro-2-thiohenic acid
(2S)-2-[5-[N-Methyl-N-[[(3,4-dihydro-2-methyl-4-oxoquinazolin)-6-yl]methyl]amino]-2-thienylcarbonylamino]glutaric acid
(S)-2-[5-[N-Methyl-N-[[(3,4-dihydro-2-methyl-4-oxoquinazolin)-6-yl]methyl]amino]-2-thienylcarbonylamino]glutaric acid
ZEN-D-1694
Raltitrexed(ToMudex)
Raltirexed
(S)-2-(5-(Methyl((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-methyl)amino)thiophene-2-carboxam
N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]- L-glutamic acid
L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)- monohydrate
Raltitrexed monohydrate
Raltitrexed, >=99%
CS-664
(2s)-2-[[5-[methyl-[(2-methyl-4-oxo-1h-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic Acid
D1694
Raltitrexed (ZD1694
Raltitrexed USP/EP/BP
(S)-2-(5-(Methyl((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic acid
Tomudex
(S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid
Raltitrexe
Retitrose
TDX
112887-68-0
12887-68-0
112887-68-7
C21H22N4O6S
C21H22N4O6SxH2O
Active Pharmaceutical Ingredients
Raltitrexed
Intermediates & Fine Chemicals
Pharmaceuticals
Inhibitors
112887-68-0