Milrinone
- CAS No.
- 78415-72-2
- Chemical Name:
- Milrinone
- Synonyms
- Primacor;Milirinone;Milrinone USP;YM-018;Minong;Milrila;Corotrop;win47203;Mirinone;Corotrope
- CBNumber:
- CB8695411
- Molecular Formula:
- C12H9N3O
- Molecular Weight:
- 211.22
- MOL File:
- 78415-72-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/14 16:39:47
| Melting point | >3000C |
|---|---|
| Boiling point | 350.9°C (rough estimate) |
| Density | 1.1922 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10 mg/mL |
| form | powder |
| pka | 7.21±0.10(Predicted) |
| color | off-white |
| Water Solubility | Soluble in DMSO. Insoluble in water. |
| Merck | 14,6197 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | FYEJSUDMDUIMKJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 78415-72-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | T,T+ | |||||||||
| Risk Statements | 23/24/25-26/27/28 | |||||||||
| Safety Statements | 36/37/39-45-22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DW1762000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
Milrinone price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M4659 | Milrinone ≥97% (TLC), powder | 78415-72-2 | 10MG | ₹24410.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2515 | Milrinone Pharmaceutical Secondary Standard; Certified Reference Material | 78415-72-2 | 1G | ₹28361.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M4659 | Milrinone ≥97% (TLC), powder | 78415-72-2 | 50MG | ₹96180.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 475840 | Milrinone - CAS 78415-72-2 - Calbiochem A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC?? = 300 nM). | 78415-72-2 | 10MG | ₹27450.01 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M1663 | Milrinone | 78415-72-2 | 100MG | ₹4900 | 2022-05-26 | Buy |
Milrinone Chemical Properties,Uses,Production
Description
Milrinone, an inhibitor of phosphodiesterase selective for fraction III PDE, exerts a positive inotropic effect on the heart as well as a peripheral vasodilatory effect. Milrinone given intravenously produces significant improvements on cardiac output, pulmonary capillary wedge pressure and vascular resistance without significant effects on the heart rate.
Chemical Properties
Crystalline Solid
Uses
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
General Description
Milrinone, 1,6-dihydro-2-methyl-6-oxo-3,4＇-bipyridine-5-carbonitrile (Primacor), is another dipyridinephosphodiesterase F-III inhibitor that possesses pharmacologicalproperties similar to those of amrinone. The inhibitionof the degradation of cAMP results in an increase in the cardiacmuscle’s force of contraction.
Biological Activity
Potent cAMP phosphodiesterase inhibitor (IC 50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo . Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Milrinone Preparation Products And Raw materials
Raw materials
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| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Sai Life Sciences Ltd | +91-4066777555 +91-8008555365 | Hyderabad, India | 24 | 58 | Inquiry |
| Omshri Labs Pvt Ltd | +91-7977270534 +91-9833689647 | Maharashtra, India | 46 | 58 | Inquiry |
| Sai Life Sciences Ltd. (formerly Sai Advantium Pharma Limited) | 91-40-66777555 | Hyderabad, India | 9 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Shivam Pharma Chemicals | 91-22-26403900 | Maharashtra, India | 656 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
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