4-Methyl-2-pentanone
- CAS No.
- 108-10-1
- Chemical Name:
- 4-Methyl-2-pentanone
- Synonyms
- MIBK;METHYL ISOBUTYL KETONE;4-METHYLPENTAN-2-ONE;MIK;MIKB;Hexon;ISOBUTYL METHYL KETONE;HEXONE;4-Methyl-2-pen;ISOPROPYLACETONE
- CBNumber:
- CB8691781
- Molecular Formula:
- C6H12O
- Molecular Weight:
- 100.16
- MOL File:
- 108-10-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/27 8:43:35
| Melting point | -80 °C (lit.) |
|---|---|
| Boiling point | 117-118 °C |
| Density | 0.801 g/mL at 25 °C (lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 15 mm Hg ( 20 °C) |
| refractive index |
n |
| FEMA | 2731 | 4-METHYL-2-PENTANONE |
| Flash point | 56 °F |
| storage temp. | Store at +5°C to +30°C. |
| solubility | water: soluble20g/L, soluble in alcohol, miscible with oils. Soluble in Propylene glycol and Glycerin. |
| form | Liquid |
| color | APHA: ≤15 |
| Specific Gravity | 0.80 |
| Odor | Pleasant; mild, characteristic; sharp; non-residual; ketonic. |
| Odor Threshold | 0.17ppm |
| explosive limit | 1.2-8%, 93°F |
| Odor Type | green |
| Water Solubility | 17 g/L (20 ºC) |
| λmax |
λ: 335 nm Amax: 1.00 λ: 340 nm Amax: 0.50 λ: 360 nm Amax: 0.15 λ: 380 nm Amax: 0.02 λ: 400 nm Amax: 0.01 |
| Merck | 14,5207 |
| JECFA Number | 301 |
| BRN | 605399 |
| Henry's Law Constant | 2.56 at 25 °C (batch stripping method-GC, Kim et al., 2000) |
| Exposure limits | TLV-TWA 205 mg/m3 (50 ppm); STEL 300 mg/m3 (75 ppm) (ACGIH); IDLH 3000 ppm (NIOSH). |
| Dielectric constant | 13.0（Ambient） |
| Stability | Volatile |
| LogP | 1.3-1.9 at 20℃ |
| CAS DataBase Reference | 108-10-1(CAS DataBase Reference) |
| IARC | 2B (Vol. 101) 2013 |
| NIST Chemistry Reference | Methyl isobutyl ketone(108-10-1) |
| EPA Substance Registry System | Methyl isobutyl ketone (108-10-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H332-H335 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xn,T | |||||||||
| Risk Statements | 11-20-36/37-66-39/23/24/25-23/24/25 | |||||||||
| Safety Statements | 9-16-29-45-36/37-7 | |||||||||
| RIDADR | UN 1245 3/PG 2 | |||||||||
| OEB | A | |||||||||
| OEL | TWA: 50 ppm (205 mg/m3), STEL: 75 ppm (300 mg/m3) | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | SA9275000 | |||||||||
| Autoignition Temperature | 840 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2914 13 00 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 orally in rats: 2.08 g/kg (Smyth) | |||||||||
| IDLA | 500 ppm | |||||||||
| NFPA 704 |
|
4-Methyl-2-pentanone price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W273104 | 4-Methyl-2-pentanone ≥99%, FCC | 108-10-1 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W273104 | 4-Methyl-2-pentanone ≥99%, FCC | 108-10-1 | 1KG | ₹6852.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20820 | Isobutyl methyl ketone EMPLURA? | 108-10-1 | 8208200521 | ₹620.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20820 | Isobutyl methyl ketone EMPLURA? | 108-10-1 | 8208202521 | ₹2770 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W273104 | 4-Methyl-2-pentanone ≥99%, FCC | 108-10-1 | 8KG | ₹16464.83 | 2022-06-14 | Buy |
4-Methyl-2-pentanone Chemical Properties,Uses,Production
Description
4-Methyl-2-pentanone has a pleasant odor. May be prepared by hydrogenation of mesityl oxide over Ni at 160 - 190°C; also by oxidation of methyl isobutyl carbinol.
Chemical Properties
4-Methyl-2-pentanone has a fruity, ethereal, spicy (on dilution) odor.
Chemical Properties
4-Methyl-2-pentanone, also known as Methyl isobutyl ketone (MIBK), is a colorless liquid with a pleasant, sweet, fruity odor. The odor threshold can be as low as 0.10 ppm. It is 2% soluble in water by weight and with several other organic solvents. The lower explosive limit is 1.2% and the upper explosive limit is 8.0% at 200 °F. Methyl isobutyl ketone may be incompatible with strong oxidizers and potassium tert-butoxide.
Physical properties
Clear, colorless, watery liquid with a mild, pleasant odor. Odor threshold concentration is 47 ppbv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 400 μg/m3 (100 ppbv) and 1.1 mg/m3 (270 ppbv), respectively (Hellman and Small, 1974).
Occurrence
Reported found in orange and lemon juice, grape; vinegar, baked potato, papaya, ginger, wheat bread, cheeses, milk, cooked egg, roast chicken, cooked beef, lamb fat, pork liver, hop oil, beer, cognac, coffee, tea, plumcot, plum brandy, mushroom, trassi, sesame seed, buckwheat, wort, elder flower, Bourbon vanilla, clary and red sage, crab, clam and Chinese quince.
Uses
Methyl isobutyl ketone (hexone, isobutyl methyl ketone, 4-methyl-2-pentanone) is an organic solvent similar in structure and use to methyl butyl ketone. In addition to its use as a solvent for paints, lacquers, and varnishes, methyl isobutyl ketone is used in extraction processes and as a denaturant for rubbing alcohol. Methyl isobutyl ketone is also used as a synthetic flavoring in some varieties of rum, candy, and cheese. Unlike methyl butyl ketone, methyl isobutyl ketone has not been found to occur naturally.
Production Methods
Methyl isobutyl ketone can be manufactured by two processes . The first is a mixed ketone process where MiBK, diisobutyl ketone, and acetone are coproduced in a single reaction using isopropanol as a starting material. The second method is used to produce the majority of MiBK and involves a three-step reaction sequence in which diacetone alcohol and mesityl oxide are formed as intermediates.
Preparation
By hydrogenation of mesityl oxide over Ni at 160 to 190°C; also by oxidation of methyl isobutyl carbinol.
General Description
A clear colorless liquid with a pleasant odor. Flash point 73°F. Less dense than water. Vapors heavier than air.
Air & Water Reactions
Highly flammable. 4-Methyl-2-pentanone is sensitive to air (may form explosive peroxides). Slightly soluble in water.
Reactivity Profile
4-Methyl-2-pentanone is incompatible with caustic soda and other strong alkalis, hydrochloric acid, sulfuric acid and other strong inorganic acids, amines and oxidizing agents such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. 4-Methyl-2-pentanone reacts violently with potassium tert-butoxide. 4-Methyl-2-pentanone reacts vigorously with reducing materials. .
Hazard
Flammable, dangerous fire risk, explosivelimits in air 1.4–7.5%. Avoid ingestion and inhala-tion. Upper respiratory tract irritant, dizziness, andheadache. Possible carcinogen.
Health Hazard
Vapor causes irritation of eyes and nose; high concentrations cause anesthesia and depression. Liquid dries out skin and may cause dermatitis; irritates eyes but does not injure them.
Chemical Reactivity
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Potential Exposure
MIBK is used as a solvent; a denaturant; and as an extractant; in the manufacture of methyl amyl alcohol; as a solvent in paints, varnishes, and lacquers; as an alcohol denaturant; as a solvent in uranium extraction from fission products.
Carcinogenicity
The National Toxicology Program
conducted cancer bioassays by exposing groups of
50 male and 50 female F344 rats and B6C3F1 mice to
MiBK vapor at 0, 450, 900, or 1800 ppm 6h/day, 5 days/
week for 2 years. Survival and body weight gain
were decreased in male rats at 1800 ppm. Body weight
gain was also decreased in male rats at 900 and in female
mice at 1800ppm. A higher incidence of mineralization of
the renal papilla was observed in male rats at all MiBK
exposure levels. Chronic progressive nephropathy (CPN) and
the incidences of adenoma and adenoma or carcinoma
(combined) were increased for the male 1800 ppm exposure
group. The severity of CPN and renal tubular hyperplasia was
increased in all male rat exposure groups. An uncertain
increase in mononuclear cell leukemia, adrenal medulla
hyperplasia, and a positive trend for increases in benign or
malignant pheochromocytomas (combined) were reported
for the 1800 ppm male group. The NTP considered that there
was some evidence of carcinogenic activity in male rats
based on increased incidences of renal tubule neoplasms.
None of the rodent bioassay results were considered clear
evidence of carcinogenicity by NTP.
Shipping
UN1245 Methyl isobutyl ketone, Hazard Class: 3; Labels: 3-Flammable liquid.
Purification Methods
Reflux the ketone with a little KMnO4, wash it with aqueous NaHCO3, dry with CaSO4 and distil it. Acidic impurities are removed by passage through a small column of activated alumina. [Beilstein 1 IV 3305.]
Incompatibilities
Able to form unstable and explosive peroxides on contact with air. Reacts violently with strong oxidizers, potassium tert-butoxide; strong acids; aliphatic amines; reducing agents
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.
4-Methyl-2-pentanone Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SHIVAM INDUSTRIES | +91-9820823043 +91-9820823043 | Mumbai, India | 30 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Newage Industrial Oils Pvt Ltd NIOPL | +91-846005276 +91-8866035309 | Gujarat, India | 11 | 58 | Inquiry |
| Baron Organics | +91-9825029778 +91-9825029778 | Gujarat, India | 13 | 58 | Inquiry |
| Ridhdhi Sidhdhi Chemicals | +91 9909006960 +91 9909006962 | Gujarat, India | 13 | 58 | Inquiry |
| Cognizant Chemical Pvt Ltd | +91-9819500500 +91-9819500500 | Maharashtra, India | 14 | 58 | Inquiry |
| Benzer Multitech India Pvt Ltd | +91-9769550991 +91-9730539955 | Maharashtra, India | 45 | 58 | Inquiry |
| Prasol Chemicals Pvt Ltd | 91-22-27782555 | Maharashtra, India | 27 | 58 | Inquiry |
| G C Int'L | 91-22-40850400 | Maharashtra, India | 125 | 58 | Inquiry |
| Hrishabh Life Sciences | 91-22-62215755 | Maharashtra, India | 159 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SHIVAM INDUSTRIES | 58 |
| JSK Chemicals | 58 |
| Newage Industrial Oils Pvt Ltd NIOPL | 58 |
| Baron Organics | 58 |
| Ridhdhi Sidhdhi Chemicals | 58 |
| Cognizant Chemical Pvt Ltd | 58 |
| Benzer Multitech India Pvt Ltd | 58 |
| Prasol Chemicals Pvt Ltd | 58 |
| G C Int'L | 58 |
| Hrishabh Life Sciences | 58 |
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