Ranitidine
![Ranitidine Structure](CAS/GIF/66357-35-5.gif)
- CAS No.
- 66357-35-5
- Chemical Name:
- Ranitidine
- Synonyms
- RANITIDINE BASE;Trigger;Ranitidin;RND;U1cex;Zantae;Taural;Zantic;Sampep;Sostril
- CBNumber:
- CB5480252
- Molecular Formula:
- C13H22N4O3S
- Molecular Weight:
- 314.4
- MOL File:
- 66357-35-5.mol
- Modify Date:
- 2024/4/26 17:21:34
Melting point | 69-70°C |
---|---|
Boiling point | 437.1±45.0 °C(Predicted) |
Density | 1.184±0.06 g/cm3(Predicted) |
storage temp. | Desiccate at +4°C |
solubility | H2O: 1.8 mg/mL |
form | solid |
pka | pKa 2.19±0.04 (Uncertain) |
color | tan |
Water Solubility | 24.7 mg/mL |
Stability | Hygroscopic |
CAS DataBase Reference | 66357-35-5(CAS DataBase Reference) |
NIST Chemistry Reference | Ranitidine(66357-35-5) |
EPA Substance Registry System | 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro- (66357-35-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 |
Safety Statements | 22-24/25 |
WGK Germany | 2 |
RTECS | KM6557000 |
Toxicity | LD50 oral in rat: > 5gm/kg |
Ranitidine Chemical Properties,Uses,Production
Description
Ranitidine, a H2-receptor agonist, caused contact dermatitis within the pharmaceutical industry.
Uses
Ranitidine (cas# 66357-35-5) was used as a standard for testing the therapeutic effect of brown propolis extract against aspirin and ethanol- induced gastric ulcers.
Indications
Ranitidine (Zantac) is another H2 receptor antagonist that does not have the same antiandrogen side effects as cimetidine. Note that both cimetidine and ranitidine inhibit the cytochrome P-450 microsomal enzyme system.
General Description
Ranitidine, N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thiol] ethyl]-N'-methyl-2-nitro-l,1-ethenediamine (Zantac), is a white solid, which inits hydrochloride salt form is highly soluble in water. It is anaminoalkyl furan derivative with pKa values of 2.7 (sidechain) and 8.2 (dimethylamino). Ranitidine is more potentthan cimetidine, but less potent than famotidine. Likeother H2-antagonists, it does not appear to bind to otherreceptors.
Bioavailability of an oral dose of ranitidine is about 50%and is not significantly affected by the presence of food.Some antacids may reduce ranitidine absorption and shouldnot be taken within 1 hour of administration of this drug. Theplasma half-life of the drug is 2 to 3 hours, and it is excretedalong with its metabolites in the urine. Three metabolites, ranitidineN-oxide, ranitidine S-oxide, and desmethyl ranitidine,have been identified. Ranitidine is only a weak inhibitor ofthe hepatic cytochrome isozymes, and recommended doses ofthe drug do not appear to inhibit the metabolism of otherdrugs. However, there have been isolated reports of drug interactions(warfarin, triazolam) that suggest that ranitidinemay affect the bioavailability of certain drugs by someunidentified mechanism, perhaps by pH-dependent effect onabsorption or a change in volume of distribution.
In addition to being available in various dosage forms asthe hydrochloride salt, ranitidine is also available as a bismuthcitrate salt for use with the macrolide antibiotic clarithromycinin treating patients with an active duodenalulcer associated with H. pylori infection. Eradication of H.pylori reduces the risk of duodenal ulcer recurrence.
Biological Activity
Potent, selective and competitive histamine H 2 receptor antagonist (pA 2 = 6.95-7.2). In vivo, inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food. Also inhibits aspirin-induced gastric lesions.
Contact allergens
Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.
Ranitidine Preparation Products And Raw materials
Raw materials
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Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
ChemBioReas Life Sciences | +91-7989264158 +91-7989264158 | Hyderabad, India | 82 | 58 | Inquiry |
Vivimed Labs Ltd | +914066086608 | Telangana, India | 61 | 58 | Inquiry |
SMS Pharmaceuticals Ltd | +91-8179850881 +91-9100092121 | Telangana, India | 22 | 58 | Inquiry |
Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Supplier | Advantage |
---|---|
ChemBioReas Life Sciences | 58 |
Vivimed Labs Ltd | 58 |
SMS Pharmaceuticals Ltd | 58 |
Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
Alfa Omega Pharma | 58 |
Frolic Pharmachem | 58 |
Molsyns Research | 58 |
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
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