Ranitidine | 66357-35-5

Ranitidine Properties

Melting point	69-70°C
Boiling point	437.1±45.0 °C(Predicted)
Density	1.184±0.06 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	H₂O: 1.8 mg/mL
form	solid
pka	pKa 2.19±0.04 (Uncertain)
color	tan
Water Solubility	24.7 mg/mL
Stability	Hygroscopic
CAS DataBase Reference	66357-35-5(CAS DataBase Reference)
NIST Chemistry Reference	Ranitidine(66357-35-5)
EPA Substance Registry System	1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro- (66357-35-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
Safety Statements	22-24/25
WGK Germany	2
RTECS	KM6557000
Toxicity	LD50 oral in rat: > 5gm/kg

Ranitidine Chemical Properties,Uses,Production

Description

Ranitidine, a H2-receptor agonist, caused contact dermatitis within the pharmaceutical industry.

Uses

Ranitidine (cas# 66357-35-5) was used as a standard for testing the therapeutic effect of brown propolis extract against aspirin and ethanol- induced gastric ulcers.

Indications

Ranitidine (Zantac) is another H2 receptor antagonist that does not have the same antiandrogen side effects as cimetidine. Note that both cimetidine and ranitidine inhibit the cytochrome P-450 microsomal enzyme system.

General Description

Ranitidine, N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thiol] ethyl]-N'-methyl-2-nitro-l,1-ethenediamine (Zantac), is a white solid, which inits hydrochloride salt form is highly soluble in water. It is anaminoalkyl furan derivative with pKa values of 2.7 (sidechain) and 8.2 (dimethylamino). Ranitidine is more potentthan cimetidine, but less potent than famotidine. Likeother H2-antagonists, it does not appear to bind to otherreceptors.
Bioavailability of an oral dose of ranitidine is about 50%and is not significantly affected by the presence of food.Some antacids may reduce ranitidine absorption and shouldnot be taken within 1 hour of administration of this drug. Theplasma half-life of the drug is 2 to 3 hours, and it is excretedalong with its metabolites in the urine. Three metabolites, ranitidineN-oxide, ranitidine S-oxide, and desmethyl ranitidine,have been identified. Ranitidine is only a weak inhibitor ofthe hepatic cytochrome isozymes, and recommended doses ofthe drug do not appear to inhibit the metabolism of otherdrugs. However, there have been isolated reports of drug interactions(warfarin, triazolam) that suggest that ranitidinemay affect the bioavailability of certain drugs by someunidentified mechanism, perhaps by pH-dependent effect onabsorption or a change in volume of distribution.
In addition to being available in various dosage forms asthe hydrochloride salt, ranitidine is also available as a bismuthcitrate salt for use with the macrolide antibiotic clarithromycinin treating patients with an active duodenalulcer associated with H. pylori infection. Eradication of H.pylori reduces the risk of duodenal ulcer recurrence.

Biological Activity

Potent, selective and competitive histamine H 2 receptor antagonist (pA 2 = 6.95-7.2). In vivo, inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food. Also inhibits aspirin-induced gastric lesions.

Contact allergens

Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.

Ranitidine Preparation Products And Raw materials

Raw materials

Nitroethylene Dimethyl sulfide L-Cysteine Furfuryl alcohol 4-Methyl-2-pentanone

2,2'-Thiobisethylamine N,N-dimethyl-2-furfurylamine 2-(NITROMETHYLENE)THIAZOLIDINE N-Methyl-1-(methylthio)-2-nitroethylen-1-amine 5-[(DIMETHYLAMINO)METHYL]-2-FURANMETHANOL

1,1-dichloro-2-nitroethene 5-[[(2-Aminoethyl)thio]methyl]-N,N-dimethyl-2-furfurylamine 1,4-Dioxane Cysteamine hydrochloride

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Preparation Products

Ranitidine Suppliers

Global( 242)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ChemBioReas Life Sciences	+91-7989264158 +91-7989264158	Hyderabad, India	82	58	Inquiry
Vivimed Labs Ltd	+914066086608	Telangana, India	61	58	Inquiry
SMS Pharmaceuticals Ltd	+91-8179850881 +91-9100092121	Telangana, India	22	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Alfa Omega Pharma	+91-8050045945 +91-9972665399	Maharashtra, India	126	58	Inquiry
Frolic Pharmachem	+919711094561	Himachal Pradesh, India	94	58	Inquiry
Molsyns Research	+91-9586858886 +91-9586858886	Gujarat, India	418	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry

Supplier	Advantage
ChemBioReas Life Sciences	58
Vivimed Labs Ltd	58
SMS Pharmaceuticals Ltd	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Alfa Omega Pharma	58
Frolic Pharmachem	58
Molsyns Research	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58

66357-35-5(Ranitidine)Related Search:

Ranitidine Hydrochloride N-METHYL-2-NITROACETAMIDE 2,2'-Methylene Bis[Ranitidine] Ranitidine hydrochloride Propyl gallate

N-Methyl-1-(methylthio)-2-nitroethylen-1-amine Ranitidinebismuthcitrate Ranitidine N,N'-BIS[2-[5-(DIMETHYLAMINOMETHYL)FURFURYLTHIO]ETHYL]-2-NITRO-1,1-ETHENDIAMINE N-(1,3-benzodioxol-5-ylmethyl)-N'-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-2-nitrovinylidenediamine

RANITIDINE-N-OXIDE RANITIDINE IMPURITY C RANITIDINE IMPURITY AN,N'-BIS[2-[[[5-[(DIMETHYLAMINO)METHYL]FURAN-2-YL]METHYL]THIO]ETHYL]-2-NITROETHENE-1,1-DIAMINE EPR(CRM STANDARD) RANITIDINE RELATED COMPOUND A 5-[[(2-AMINOETHYL)THIO]METHYL]-N,N-DIMETHYL-2-FURANMETHANAMINE HEMIFUMARATE USP(CRM STANDARD) RANITIDINE HYDROCHLORIDE ASSAY STANDARD BP(CRM STANDARD)

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1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro- 1,1-ethenediamine,n-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)eth RANITIDINE TIMTEC-BB SBB006527 N’-Methyl-N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-2-nitro-1-ethenediarnine Sostril Taural Terposen U1cex U1tidine Zantae Zantic RANITIDINE USP Ranitidine (Rantadine) HCl RANITIDINE FORM I RANITIDINE FORM II N'-[2-[[5-(Dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-N-methyl-2-nitro-ethene-1,1-diamine hydrochloride 1,1-ethenediamine,n-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethy l)-n’-methyl-2-nitro- n-(2-(((-5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n’-methyl-2-ni N-[2-[[5-[(Dimethylamino)methyl]furfuryl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine N-[2-[[5-[(Dimethylamino)methyl]furfuryl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethylenediamine tro-1,1-ethenediamine yl)-n-methyl-2-nitro- 1-(Methylamino)-1-[[2-[[5-(dimethylaminomethyl)-2-furyl]methylthio]ethyl]amino]-2-nitroethene N-[1-(Methylamino)-2-nitroethenyl]-2-[5-(dimethylaminomethyl)furan-2-ylmethylthio]ethanamine N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethanediaminehydrochloride Ranitidine hydrochloride COS (E)-N-(2-(((5-((diMethylaMino)Methyl)furan-2-yl)Methyl)thio)ethyl)-N-Methyl-2-nitroethene-1,1-diaMine (E)-N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine HSDB 3925 Ranitidine hydrochlo RanitidineQ: What is Ranitidine Q: What is the CAS Number of Ranitidine Q: What is the storage condition of Ranitidine Q: What are the applications of Ranitidine Ranitidine hydrochloride HCL form II USP Ranitidin Trigger RANITIDINE BASE {2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}[(E)-1-(methylamino)-2-nitroethenyl]amine RANITIDINE HYDROCHLORIDE IH Raticina RND Sampep Ranitidine Reference Standard 66357-35-5 C13H16D6N4O3S C13H22N4O3S Cell Signaling Enzymes Application Index Biochemicals and Reagents BioChemical Substrates Xenobiotics and Drug Metabolism Enzymes, Inhibitors, and Substrates API Active Pharmaceutical Ingredients 66357-35-5