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Domperidone

Domperidone Structure
CAS No.
57808-66-9
Chemical Name:
Domperidone
Synonyms
DOMPERIDONE BASE;kw-5338;Domperidon;5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one;gj;Evoxin;Euciton;Peridon;Peridys;R-33812
CBNumber:
CB8699080
Molecular Formula:
C22H24ClN5O2
Molecular Weight:
425.91
MOL File:
57808-66-9.mol
Modify Date:
2024/4/26 17:21:34
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Domperidone Properties

Melting point 240-244°C
Density 1.2904 (rough estimate)
refractive index 1.5400 (estimate)
storage temp. Store at RT
solubility DMSO: >10 mg/mL
pka pKa 7.90 (Uncertain)
form solid
color white
Water Solubility Slightly soluble in water.
Merck 14,3418
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey FGXWKSZFVQUSTL-UHFFFAOYSA-N
CAS DataBase Reference 57808-66-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361fd
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  62-63
Safety Statements  26-36
WGK Germany  3
RTECS  DE2275900
HS Code  29333990

Domperidone price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D122 Domperidone powder, ≥98% (HPLC) 57808-66-9 25MG ₹6386.75 2022-06-14 Buy
Sigma-Aldrich(India) D122 Domperidone powder, ≥98% (HPLC) 57808-66-9 100MG ₹17428.25 2022-06-14 Buy
Sigma-Aldrich(India) D122 Domperidone powder, ≥98% (HPLC) 57808-66-9 500MG ₹69864.55 2022-06-14 Buy
TCI Chemicals (India) D4125 Domperidone 57808-66-9 200MG ₹13100 2022-05-26 Buy
TCI Chemicals (India) D4125 Domperidone 57808-66-9 1G ₹17400 2022-05-26 Buy
Product number Packaging Price Buy
D122 25MG ₹6386.75 Buy
D122 100MG ₹17428.25 Buy
D122 500MG ₹69864.55 Buy
D4125 200MG ₹13100 Buy
D4125 1G ₹17400 Buy

Domperidone Chemical Properties,Uses,Production

Chemical Properties

White or almost white powder.

Uses

A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

Definition

ChEBI: 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used s an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet reparations.

World Health Organization (WHO)

Domperidone, a peripheral dopaminergic antagonist, was introduced in 1979 for the symptomatic relief of acute nausea and vomiting. The major manufacturer became aware that the injectable formulation was being used in some countries in much higher doses than those recommended to combat nausea and vomiting in cancer patients treated with cytostatic agents. Such use - which was not in conformity with the approved indications - was associated with cardiotoxicity, which in some cases was fatal, and the manufacturer decided to withdraw the injectable dosage form from the market worldwide in January 1985. Suppositories, tablets and a suspension remain available and the manufacturer continues to supply the injection for the treatment of a named patient at the written request of a doctor on the understanding that the appropriate dosage recommendations will be followed.

Biological Activity

Peripheral dopamine D 2 -like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED 50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).

Domperidone Preparation Products And Raw materials

Raw materials

Silica gel Benzimidazole 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester N,N-Dimethylformamide Potassium iodide
2-Nitrochlorobenzene Hydroxypropyl Chloroform 4-AMINOCYCLOHEXANECARBOXYLIC ACID 4-Methyl-2-pentanone
POTASSIUM CYANIDE 5-CHLORO-1,3-BENZODIOXOLE
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Preparation Products

Domperidone Suppliers

Global( 652)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TAGOOR LABORATORIES PVT LTD +919700187008 AndhraPradesh, India 93 58 Inquiry
THE MOLECULEZ +91-7506703683 +91-7506703683 Maharashtra, India 79 58 Inquiry
SURYA LIFE SCIENCES LIMITED +91-2646226290 +91-9428511112 Gujarat, India 62 58 Inquiry
ANWITA APIS +919000311012 Hyderabad, India 198 58 Inquiry
SGMR PHARMACEUTICALS PVT LTD +91-9032001889 +91-9032001889 Telangana, India 83 58 Inquiry
Frolic Pharmachem +919711094561 Himachal Pradesh, India 94 58 Inquiry
Reenold Enterprises +91-8208173540 +91-8208173540 Maharashtra, India 28 58 Inquiry
Prachi Pharmaceuticals Pvt Ltd +919004877711 Mumbai, India 36 58 Inquiry
Macleods Pharmaceuticals Limited +91-2266762800 +91-2266762800 Maharashtra, India 116 58 Inquiry
Sainor Life Sciences Pvt Ltd +919542990009 AndhraPradesh, India 13 58 Inquiry
Supplier Advantage
TAGOOR LABORATORIES PVT LTD 58
THE MOLECULEZ 58
SURYA LIFE SCIENCES LIMITED 58
ANWITA APIS 58
SGMR PHARMACEUTICALS PVT LTD 58
Frolic Pharmachem 58
Reenold Enterprises 58
Prachi Pharmaceuticals Pvt Ltd 58
Macleods Pharmaceuticals Limited 58
Sainor Life Sciences Pvt Ltd 58

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Domperidone Spectrum

Domperidone(57808-66-9)1HNMR

57808-66-9(Domperidone)Related Search:

Phenformin Haloperidol DROPERIDOL DOMPERIDONE MALEATE Benzimidazole
DoMperidone EP IMpurity B DoMperidone-d6 Domperidone Impurity 15 1-(3-chloropropyl)-1,3-dihydro-3-(1-methylvinyl)-2H-benzimidazol-2-one 1-(3-BroMopropyl)-1,3-dihydro-2H-benziMidazol-2-one
1-PIPERIDINECARBOXYLIC ACID, 4-[(4-AMINO-5-CHLOROPHENYL)AMINO], ETHYL ESTER 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one 1-(2-PROPENYL)-2-BENZIMIDAZOLIDINONE ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
DoMperidone EP IMpurity D 2H-Benzimidazol-2-one, 1,1'-(1,3-propanediyl)bis[1,3-dihydro- ethyl 4-[(4-chloro-2-nitrophenyl)amino]piperidine-1-carboxylate
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midazol-1-yl)propyl)-4-piperidinyl)- Domperidone,Motilium 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one DoMperidone-d6 DoMperidone Sustained Release Pellets Domperidone, >=99% DataBase Reference DOMPERIDONE - 10% W/W PELLETS 2h-benzimidazol-2-one,1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzi 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidaz DOMPERIDONE 4-(5-chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine MOTILIUM DOMPERIDONE PERIPHERAL DOPAMINE A 3-(3-Choro Propyl)-2,3 Dihydro 1H Benzimidazole-2-One Euciton Evoxin Gastronorm Moperidone Nauzelin Peridon Peridys R-33812 DOMPERIDONE,BP,EP Demperidone 5-chloro-1-(1-[3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl]piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one 5-Chloro-1-[1-[3-(2，3-dihydro-2-oxo-lH-benzimidazol-1-y1)-propyl]-4-piperidyl]-1，3-dihydro-2H-benzimidazol-2-one ALPHA-[2-(DIISOPROPYLAMINO)ETHYL]-ALPHA-PHENYL-2-PYRIDINE-ACETAMIDE 5-CHLORO-1-[1-[3-(2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOL-1-YL)PROPYL]-4-PIPERIDINYL]-1,3-DIHYDRO-2H-BENZ-IMIDAZOL-2-ONE 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone 1-[3-[4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidyl]propyl]-2,3-dihydro-1H-benzimidazol-2-one 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one 3-(3-CHLOROPROPYL)-2,3-DIHYDRO-1H-BENZIMIDAZOLE-2-ONE (Domperidone) Soluble soybean polysaccharides Domperidone, 98%, dopamine blocker and an antidopaminergic reagent Domperidone Maletate Domperidone - pharma grade Soluble soybean polysaccharide More Pan Li ketone Domperidone> Domperidone CRS 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro- Domperidone USP/EP/BP Domperidone powder Domperidone- IP/BP/Ph. Eur Domperidone (R33812) Domperidone BP kw-5338 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one DOMPERIDONE BASE Domperidon Nifedipine 21829-25-4 DOMPERIDONE 13.5% , 19.2% , 20% PELLETS DOMPERIDONE IP gj 57808-66-9 57808-66-5 C22H18D6ClN5O2