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Loperamide

CAS No.: 53179-11-6

Chemical Name:: Loperamide

Synonyms: C07080;Tebloc;utanamide;LOPERAMIDE;Loperamide Monomer;Loperamide USP/EP/BP;4-(4-chlorophenyl)-n,n-dimethyl-alpha;4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide

CBNumber:: CB7402928

Molecular Formula:: C29H33ClN2O2

Molecular Weight:: 477.04

MOL File:: 53179-11-6.mol

MSDS File:: SDS

Modify Date:: 2024/3/19 15:37:50

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Loperamide Properties

Boiling point	647.2±55.0 °C(Predicted)
Density	1.187±0.06 g/cm3(Predicted)
pka	pKa 8.66(H2O) (Uncertain)
BCS Class	4
LogP	2.641 at 25℃ and pH6.95
CAS DataBase Reference	53179-11-6(CAS DataBase Reference)
NIST Chemistry Reference	Loperamide(53179-11-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501

Loperamide Chemical Properties,Uses,Production

Uses

Loperamide is presently used more often as an antidiarrheal drug than as an analgesic, and it is also included in the list of over-the-counter drugs because of its insignificant action on the CNS. It reduces intestinal smooth muscle tone and motility as a result of binding to intestinal opiate receptors. It is used for symptomatic treatment of severe and chronic diarrhea of various origins. The most popular synonym for loperamide is imodium.

Definition

ChEBI: A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

World Health Organization (WHO)

Loperamide, an inhibitor of intestinal peristalsis, was introduced in 1975 for the treatment of acute and chronic diarrhoea. In many countries its use was discouraged in young children. In late 1989, treatment of infants in Pakistan was associated with 19 cases of paralytic ileus, 6 of which have been fatal. This has subsequently led the major manufacturer to withdraw all drop formulations of the drug worldwide as well as the lower dose syrup forms from countries where there is a programme for the control of diarrhoeal diseases. The WHO Control of Diarrhoeal Diseases Programme recommends that loperamide should not be used in children below five year of age. (Reference: (LJJ) Letter to WHO from Johnson & Johnson, , , 21 June 1990)

General Description

Loperamide (Imodium) is a 4-phenylypiperidine with amethadone-like structure attached to the piperidine nitrogen. It acts as an antidiarrheal by directly binding tothe opiate receptors in the gut wall. Loperamide inhibitsacetylcholine and prostaglandin release, decreasing peristalsisand fluid secretion thus increasing the GI transit time andreducing the volume of fecal matter.Loperamide is sufficiently lipophilic to cross the blood-brain barrier, yet itdisplays no CNS-opioid effects. The reason for this is that itis actively pumped out of the brain via the P-glycoproteinpump (MDR1). Knockout mice with the P-glycoproteinpump genetically removed were given radiolabeled loperamideand sacrificed 4 hours later. The [³H]loperamideconcentrations were measured and compared with wild-typemice. A 13.5-fold increase in loperamide concentration wasfound in the brain of the knockouts. In addition, the micelacking the P-glycoprotein pump displayed pronouncedsigns of central opiate agonism. Loperamide is availableas 2-mg capsules for treatment of acute and chronic diarrhea.Recommended dosage is 4 mg initially, with 2 mgafter each loose stool for a maximum of 16 mg/d.

Loperamide Preparation Products And Raw materials

Raw materials

Epoxy 4-Hydroxypiperidine Diphenylacetonitrile Potassium iodide Acetic acid

Hydrogen isopropoxide 4-Methyl-2-pentanone Dimethylamine Sodium amide Sodium carbonate

Hydrochloric acid 4-(4-Chlorophenyl)piperidin-4-ol Thionyl chloride Hydrogen bromide Benzeneacetyl chloride, a-(2-bromoethyl)-a-phenyl-

ALPHA,ALPHA-DIPHENYL-GAMMA-BUTYROLACTONE 3,3-Diphenyltetrahydrofuran-2-ylidene(dimethyl)ammonium bromide 4-Bromo-2,2-diphenylbutyric acid

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Preparation Products

Loperamide Suppliers

Global( 69)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
KARPSCHEM LABORATORIES	+91-7249203006 +91-7249203006	Maharashtra, India	786	58	Inquiry
Chempro Pharma Pvt Ltd	+91-9967544178 +91-9967544178	Maharashtra, India	4	58	Inquiry
VIVAN Life Sciences Pvt Ltd	+91-2225870080 +91-9987465183	Maharashtra, India	49	58	Inquiry
Medilink Pharmachem	+91 (79) 3007-0133	New Delhi, India	424	50	Inquiry
Biokemix	+91 (40) 6662-6366	New Delhi, India	487	50	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry

Supplier	Advantage
KARPSCHEM LABORATORIES	58
Chempro Pharma Pvt Ltd	58
VIVAN Life Sciences Pvt Ltd	58
Medilink Pharmachem	50
Biokemix	50
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

53179-11-6(Loperamide)Related Search:

Diphenylphosphine Albuterol sulfate DOBUTAMINE Diphenyldimethoxysilane Dimethyl carbonate

ETHANE tert-Butylchlorodiphenylsilane 1,3-Diphenyl-2-thiourea Dichlorodiphenylsilane Chlorodiphenylphosphine

Dimethyl fumarate Diphenylsilane Dimethyl sulfoxide Diphenylmethane Salbutamol

N,N-Dimethylformamide Loperamide hydrochloride, Vetranal,LOPERAMIDE HYDROCHLROIDE,LOPERAMIDE HCL,LOPERAMIDE HYDROCHLORIDE Tributylamine

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4-[4-Chlorophenyl]-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide LOPERAMIDE 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-di(phenyl)butanamide 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N DIMETHYL-A,A DIPHENYL-1-PEIPERIDINE BUTANAMIDEHCL 4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-2,2-diphenyl-N,N-dimethylbutyramide 4-[4-Hydroxy-4-(4-chlorophenyl)-1-piperidinyl]-2,2-diphenyl-N,N-dimethylbutanamide C07080 Tebloc utanamide 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide 4-(4-chlorophenyl)-n,n-dimethyl-alpha 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl- Loperamide USP/EP/BP LoperamideQ: What is Loperamide Q: What is the CAS Number of Loperamide Q: What is the storage condition of Loperamide 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide Loperamide 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl- 2,2-diphenylbutanamide Loperamide Monomer 53179-11-6 C29H33ClN2O2