Phenyllithium
![Phenyllithium Structure](CAS/GIF/591-51-5.gif)
- CAS No.
- 591-51-5
- Chemical Name:
- Phenyllithium
- Synonyms
- PHLI;Phenyllithium, typically 1.9 M in dibutylether;LITHIUMPHENYL;PHENYLLITHIUM;phenyl-lithiu;Lithiobenzene;phenyll-Lithium;PHENYLLITHIUM DIBUTYL;phenyllithium solution;20%solutioninDibutylether
- CBNumber:
- CB4853905
- Molecular Formula:
- C6H5Li
- Molecular Weight:
- 84.05
- MOL File:
- 591-51-5.mol
- Modify Date:
- 2024/7/25 20:04:51
Melting point | 160-163 °C(Solv: benzene (71-43-2)) |
---|---|
Boiling point | 140-143 °C |
Density | 0.835 g/mL at 25 °C |
Flash point | 20 °C |
storage temp. | Store at +2°C to +8°C. |
solubility | Miscible with ether and hydrocarbons. |
form | Dark Brown Solution |
Water Solubility | Severe reaction |
Sensitive | Air & Moisture Sensitive |
BRN | 506502 |
Stability | Moisture Sensitive |
InChIKey | NHKJPPKXDNZFBJ-UHFFFAOYSA-N |
CAS DataBase Reference | 591-51-5(CAS DataBase Reference) |
EPA Substance Registry System | Lithium, phenyl- (591-51-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS02,GHS05,GHS07 |
---|---|
Signal word | Danger |
Hazard statements | H226-H314-H335-H412 |
Precautionary statements | P210-P273-P280-P303+P361+P353-P305+P351+P338+P310 |
Hazard Codes | F,C,N,Xi |
Risk Statements | 11-14-17-34-52/53-67-66-65-50/53-22-19-35-36/37/38 |
Safety Statements | 26-36/37/39-45-61-62-60-43-16-6-8 |
RIDADR | UN 3392 4.2/PG 1 |
WGK Germany | 2 |
F | 1-10 |
TSCA | Yes |
HazardClass | 4.3 |
PackingGroup | II |
HS Code | 29319090 |
Phenyllithium Chemical Properties,Uses,Production
Chemical Properties
Phenyllithium is a colorless crystalline solid or dark brown to black solution, It is soluble in polar solvents such as ethers and tertiary amines but insoluble in hydrocarbons. Concentrated solutions in volatile solvents are pyrophoric but can be safely handled under inert atmosphere.
Uses
Phenyllithium Solution (1.9M in Dibutyl Ether) is used as catalyst in the synthesis of pharmaceuticals. Used in the preparation of sulfonamides as well as in the preparation of orally bioavailable inhibitors of lipoprotein-associated phospholipase A2.
Preparation
Phenyllithium is usually prepared in the laboratory from bromobenzene and lithium metal in diethyl ether. Since phenyllithium cleaves ether, the solution must be used within a day or refrigerated. Industrially, it is produced from chlorobenzene and lithium metal dispersion in a benzene-ether mixture. A potentially useful and inexpensive process is one in which benzene is metalated by n-butyllithium in the presence of di-tertiary amines.
Phenyllithium Preparation Products And Raw materials
Raw materials
Preparation Products
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Organo Metallics | +91-9391016448 +91-9705345345 | Telangana, India | 32 | 58 | Inquiry |
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Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5831 | 58 | Inquiry |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29896 | 58 | Inquiry |
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