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β-Carotene

β-Carotene Structure
CAS No.
7235-40-7
Chemical Name:
β-Carotene
Synonyms
β-carotene;Carotene;B-CAROTENE;Daucene;Karotin;PROVITAMIN A;β-Carotene Beadlet;C40H56;SOLATENE;Betacarotin
CBNumber:
CB4148267
Molecular Formula:
C40H56
Molecular Weight:
536.89
MOL File:
7235-40-7.mol
MSDS File:
SDS
Modify Date:
2024/7/25 20:04:51

β-Carotene Properties

Melting point 178-179 °C
Boiling point 644.94°C (rough estimate)
Density 1.000
vapor pressure 0.004Pa at 25℃
refractive index 1.5630 (estimate)
Flash point 103 °C
storage temp. -20°C
solubility hexane: 100 μg/mL, soluble
form powder
color red to purple
Water Solubility Soluble in hexane, dimethyl sulfoxide, benzene, chloroform, cyclohexane. Insoluble in water.
Sensitive Air & Light Sensitive
Merck 14,1853
BRN 1917416
Stability Stable, but sensitive to air, heat and light. Store at -20C under nitrogen. Pyrophoric - may ignite spontaneously in air at room temperature.
InChIKey OENHQHLEOONYIE-JLTXGRSLSA-N
LogP 6.5 at 40℃ and pH6.5
CAS DataBase Reference 7235-40-7(CAS DataBase Reference)
NIST Chemistry Reference «beta» Carotene(7235-40-7)
EPA Substance Registry System .beta.,.beta.-Carotene (7235-40-7)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H315-H252
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P235+P410-P280-P407-P413-P420-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xn
Risk Statements  44-36/37/38-20/21/22
Safety Statements  7-15-18-36-26-24/25
WGK Germany  1
RTECS  FI0329500
1-8-10-16
TSCA  Yes
HS Code  32030019
NFPA 704
0
0 0

β-Carotene price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1239 β-Carotene Pharmaceutical Secondary Standard; Certified Reference Material 7235-40-7 1G ₹12309.9 2022-06-14 Buy
Sigma-Aldrich(India) PHR1239 β-Carotene Pharmaceutical Secondary Standard; Certified Reference Material 7235-40-7 3X100MG ₹16372.5 2022-06-14 Buy
Sigma-Aldrich(India) C9750 β-Carotene synthetic, ≥93% (UV), powder 7235-40-7 5G ₹7392.6 2022-06-14 Buy
Sigma-Aldrich(India) C9750 β-Carotene synthetic, ≥93% (UV), powder 7235-40-7 10G ₹11910.3 2022-06-14 Buy
Sigma-Aldrich(India) C4582 β-Carotene synthetic, ≥95% (HPLC), crystalline 7235-40-7 5MG ₹5150.4 2022-06-14 Buy
Product number Packaging Price Buy
PHR1239 1G ₹12309.9 Buy
PHR1239 3X100MG ₹16372.5 Buy
C9750 5G ₹7392.6 Buy
C9750 10G ₹11910.3 Buy
C4582 5MG ₹5150.4 Buy

β-Carotene Chemical Properties,Uses,Production

Physical properties

β-Carotene is a tetraterpene with 11 conjugated double bonds that give the molecule an orange color. It is a carotenoid compound that is present in large quantities in the human diet and subsequently is found in all human tissues, including blood. High temperature encourages the isomerization of the double bonds, which lightens the color. Absorption (blue) and fluorescence emission (red) spectra at four excitation wavelengths from β-carotene in hexane solvent at 23 °C are shown below.
β-Carotene

Occurrence

Beta-carotene is available naturally in fruits and vegetables. Synthetically, it may be manufactured from fungi or algae.

Definition

ChEBI: A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.

Side effects

Side effects from β-Carotene include: Skin discoloration (yellowing that eventually goes away); Loose stools; Bruising; Joint pain.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Source

The richest sources of β-Carotene are yellow, orange, and green leafy fruits and vegetables (such as carrots, spinach, lettuce, tomatoes, sweet potatoes, broccoli, cantaloupe, and winter squash). In general, the more intense the color of the fruit or vegetable, the more beta-carotene it has.
β-Carotene

Purification Methods

It forms purple prisms when crystallised from *C6H6/MeOH and red rhombs from pet ether. Its solubility in hexane is 0.1% at 0o. It is oxygen sensitive and should be stored under N2 at -20o in the dark. It gives a deep blue colour with λmax at 590nm when mixed with SbCl3 in CHCl3. UV: (*C6H6) 429infl, max at 454 and 484nm. The principal peak at 454nm has 1cm 1% 2000. [Synthesis: Surmatis & Ofner J Org Chem 26 1171 1961; Milas et al. J Am Chem Soc 72 4844 1950.] β-Carotene is also purified by column chromatography (Al2O3 activity I-II). It is dissolved in pet ether/*C6H6 (10:1), applied to the column and eluted with pet ether/EtOH; the desired fraction is evaporated and the residue is recrystallised from *C6H6/MeOH (violet-red plates). [UV: Inhoffen et al. Justus Liebigs Ann Chem 570 54, 68 1950; Review: Fleming Selected Organic Synthesis (J Wiley, Lond) pp. 70-74 1973.] Alternatively it can be purified by chromatography on a magnesia column, thin layer of Kieselguhr or magnesia. Crystallise it from CS2/MeOH, Et2O/pet ether, acetone/pet ether or toluene/MeOH. Store it in the dark, under an inert atmosphere, at -20o. Recrystallise it also from 1:1 EtOH/CHCl3. [Bobrowski & Das J Phys Chem 89 5079 1985, Johnston & Scaiano J Am Chem Soc 1 0 8 2349 1986, Strain J Biol Chem 105 523 1934, Meth Biochem Anal 4 1 1957, Beilstein 5 II 638, 5 III 2453, 5 IV 2617.]

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