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meclocycline

meclocycline Structure
CAS No.
2013-58-3
Chemical Name:
meclocycline
Synonyms
GS-2989;NSC-78502;Aids043973;Aids-043973;MECLOCYLINE;meclocycline;Meclocycline base;Meclocycline(usan);Chlormethylenecycline;meclocycline USP/EP/BP
CBNumber:
CB7875092
Molecular Formula:
C22H21ClN2O8
Molecular Weight:
476.86
MOL File:
2013-58-3.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:12

meclocycline Properties

Melting point >167°C (dec.)
Boiling point 837.0±65.0 °C(Predicted)
Density 1.72±0.1 g/cm3(Predicted)
storage temp. Amber Vial, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 4.50±1.00(Predicted)
form Solid
color Yellow to Dark Yellow
Stability Light Sensitive

SAFETY

Risk and Safety Statements

Toxicity LD50 in mice (mg/kg): >5000 orally, 425 i.p. (Bernardi)

meclocycline Chemical Properties,Uses,Production

Uses

Meclocycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of chlortetracycline to yield an exocyclic 6-methylene. Meclocyline is a close structural analogue of methacycline. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Meclocycline has been extensively cited in the literature with over 400 references.

brand name

Meclan (Johnson & Johnson).

meclocycline Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 28)Suppliers
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SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
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Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4398 58 Inquiry
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 15229059051 China 9971 58 Inquiry
meclocycline Meclocycline base MECLOCYLINE Chlormethylenecycline (4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,5β,10,12,12aβ-pentahydroxy-6-methylene-7-chloro-1,11-dioxo-2-naphthacenecarboxamide (4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide GS-2989 NSC-78502 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,5,10,12,12A-pentahydroxy-6-methylene-1,11-dioxo-, [4S-(4.alpha.,4A.alpha.,5.alpha.,5A.alpha.,12A.alpha.)]- (9ci) Aids043973 Aids-043973 Meclocycline(usan) 7-Chloro-6-Methylene-oxytetracycline, GS 2989, NCS 78502 GGQJXCQBBONZFX-IWVLMIASSA-N 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, (4S,4aR,5S,5aR,12aS)- meclocycline USP/EP/BP Meclocycline (1.0mg/ml in DMSO) Mirabegron Impurity 86 Monomer 2013-58-3