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Ivabradine hydrochloride

CAS No.: 148849-67-6

Chemical Name:: Ivabradine hydrochloride

Synonyms: Ivabradine HCl;Procoralan;Ivabradine hydrochlorid;CS-774;S-16257;Corlentor;S 16257-2;2H-3-Benzazepin-2-on;Ivabridine hydracloride;Ivabradine hydrochloride

CBNumber:: CB81006694

Molecular Formula:: C27H37ClN2O5

Molecular Weight:: 505.05

MOL File:: 148849-67-6.mol

MSDS File:: SDS

Modify Date:: 2024/3/18 17:23:41

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Ivabradine hydrochloride Properties

Melting point	193-196?C
alpha	58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp.	2-8°C
solubility	H2O: ≥5mg/mL (warmed)
form	powder
color	white to beige
optical activity	[α]/D +5 to +9°, c = 1 in DMSO
Merck	14,5247
InChIKey	HLUKNZUABFFNQS-ZMBIFBSDSA-N
SMILES	C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl \|&1:1,r\|
CAS DataBase Reference	148849-67-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273
Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
HS Code	2933.79.1500

Ivabradine hydrochloride price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0281	Ivabradine hydrochloride ≥98% (HPLC)	148849-67-6	10MG	₹9645.08	2022-06-14	Buy
Sigma-Aldrich(India)	SML0281	Ivabradine hydrochloride ≥98% (HPLC)	148849-67-6	50MG	₹37530.28	2022-06-14	Buy
TCI Chemicals (India)	I0847	Ivabradine Hydrochloride	148849-67-6	200MG	₹9700	2022-05-26	Buy
TCI Chemicals (India)	I0847	Ivabradine Hydrochloride	148849-67-6	1G	₹25500	2022-05-26	Buy

Product number	Packaging	Price	Buy
SML0281	10MG	₹9645.08	Buy
SML0281	50MG	₹37530.28	Buy
I0847	200MG	₹9700	Buy
I0847	1G	₹25500	Buy

Ivabradine hydrochloride Chemical Properties,Uses,Production

Description

In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .

Chemical Properties

White to Off-White Solid

Uses

Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).

Definition

ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.

Ivabradine hydrochloride Preparation Products And Raw materials

Raw materials

3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one hydrochloride 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Preparation Products

Ivabradine hydrochloride Suppliers

Global( 452)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TAGOOR LABORATORIES PVT LTD	+919700187008	AndhraPradesh, India	93	58	Inquiry
SKVen Technologies Pvt.Ltd.	+91-7032295152 +91-7032295152	Hyderabad, India	81	58	Inquiry
GLP Pharma Standards	+91 9866074638	Hyderabad, India	1644	58	Inquiry
Lewens Labs	+917043057100	Gujarat, India	30	58	Inquiry
KARPSCHEM LABORATORIES	+91-7249203006 +91-7249203006	Maharashtra, India	786	58	Inquiry
Metrochem API Private Limited	+91-4069069999 +91-4069069999	Telangana, India	78	58	Inquiry
Darsh PharmaChem Pvt Ltd	+91-9712983850 +91-9712983850	Gujarat, India	33	58	Inquiry
Alembic Pharmaceuticals Limited	+91-2652280880 +91-2652280550	Gujarat, India	115	58	Inquiry
Global Calcium Pvt Ltd	+91-8050750904 +91-8040554500	Karnataka, India	132	58	Inquiry
Zydus Lifesciences Ltd.	+91-0265-2315243 +91-6358895661	Gujarat, India	89	58	Inquiry

Supplier	Advantage
TAGOOR LABORATORIES PVT LTD	58
SKVen Technologies Pvt.Ltd.	58
GLP Pharma Standards	58
Lewens Labs	58
KARPSCHEM LABORATORIES	58
Metrochem API Private Limited	58
Darsh PharmaChem Pvt Ltd	58
Alembic Pharmaceuticals Limited	58
Global Calcium Pvt Ltd	58
Zydus Lifesciences Ltd.	58

Ivabradine hydrochloride Spectrum

Ivabradine hydrochloride(148849-67-6)¹HNMR

148849-67-6(Ivabradine hydrochloride)Related Search:

METSULFURON METHYL Thiophanate-methyl Topotecan hydrochloride Dimethyldimethoxysilane 1,1-Dimethoxyethane

Methyl acetate Dimethoxymethane Cefradine Kresoxim-methyl Methyl salicylate

3-Chloropropyltrimethoxysilane Tribenuron methyl 3-Chloropropyltriethoxysilane 3-Aminopropyltriethoxysilane Ivabradine

1-AdaMantanethylaMine Polyethylene Glycol 4,4,5A-TRIMETHYLPERHYDRO-1-BENZOXIREN-2-ONE

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Ivabradine hydrochloride 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride Ivabradine hydrochloride, >=99% IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride Corlentor S-16257 (7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride 2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride 2H-3-Benzazepin-2-one, 3-(3-(((3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride, (S)- Ivabridine hydracloride 2H-3-Benzazepin-2-one,3-[3-[[[(7S)-3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-,hydrochloride (1:1) 3-[3-[[(3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-, Monohydrochloride 2H-3-Benzazepin-2-on Ivabradine HCl (Procoralan) (S)-3-(3-(((3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl)(Methyl)aMino)propyl)-7,8-diMethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride S 16257-2 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one,hydrochloride (1:1) Ivabradine hydrochloride, 98%, a If inhibitor lvabradine hydrochloride CS-774 IvabradineHydrochloride> Ivabradine hydrochloride USP/EP/BP Ivabradine Hydrochloride Impurities (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride Ivabradine HydrochlorideQ: What is Ivabradine Hydrochloride Q: What is the CAS Number of Ivabradine Hydrochloride Q: What is the storage condition of Ivabradine Hydrochloride Q: What are the applications of Ivabradine Hydrochloride Ivabradine HCl Procoralan Ivabradine hydrochlorid 2-Propen-1-one,1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-,(6E)- (S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride 148849-67-6 Ivabradine Hydrochloride (S)-3-(3-(((4,5-dimethoxy-1,2 dihydrocyclobutabenzen1yl)methyl)(methyl)amino)propyl)-7,8- dimethoxy-4,5-dihydro-1Hbenzo[d]azepin-2(3H)-one hydrochloride 148849-67-6 148849-54-6 48849-67-6 1448849-67-6 C27H37ClN2O5 C27H36N2O5HCl Chiral Reagents Heterocycles API Cardiovascular APIs Intermediates & Fine Chemicals Pharmaceuticals Inhibitors