Cyclohexylamine
- CAS No.
- 108-91-8
- Chemical Name:
- Cyclohexylamine
- Synonyms
- CHA;Cyclohexylamin;AMINOCYCLOHEXANE;HEXAHYDROANILINE;cyclohexaneamine;CHA-60;cha[qr];AURORA KA-7609;CYCLOHEXYLAMINE;hexahydro-anilin
- CBNumber:
- CB8139274
- Molecular Formula:
- C6H13N
- Molecular Weight:
- 99.17
- MOL File:
- 108-91-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | -17 °C |
|---|---|
| Boiling point | 134 °C(lit.) |
| Density | 0.867 g/mL at 25 °C(lit.) |
| vapor density | 3.42 (vs air) |
| vapor pressure | 10 mm Hg ( 22 °C) |
| refractive index |
n |
| Flash point | 90 °F |
| storage temp. | Store below +30°C. |
| solubility | organic solvents: miscible |
| form | Liquid |
| pka | 10.66(at 24℃) |
| color | Clear |
| PH | 11.5 (100g/l, H2O, 20℃) |
| Odor | strong fishy odor |
| explosive limit | 1.6-9.4%(V) |
| Water Solubility | MISCIBLE |
| FreezingPoint | -17.7℃ |
| Sensitive | Air Sensitive |
| Merck | 14,2729 |
| BRN | 471175 |
| Exposure limits | TLV-TWA 10 ppm (～40 mg/m3) (ACGIH). |
| Dielectric constant | 5.3（-21℃） |
| InChIKey | PAFZNILMFXTMIY-UHFFFAOYSA-N |
| LogP | 3.7 at 25℃ |
| CAS DataBase Reference | 108-91-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Cyclohexanamine(108-91-8) |
| EPA Substance Registry System | Cyclohexylamine (108-91-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H301+H311-H302+H312-H314-H361fd | |||||||||
| Precautionary statements | P202-P210-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 10-21/22-34-62-24-22 | |||||||||
| Safety Statements | 36/37/39-45-1/2-26 | |||||||||
| OEB | A | |||||||||
| OEL | TWA: 10 ppm (40 mg/m3) | |||||||||
| RIDADR | UN 2357 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | GX0700000 | |||||||||
| F | 10-34 | |||||||||
| Autoignition Temperature | 559 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2921 30 10 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 orally in rats: 0.71 ml/kg (Smyth) | |||||||||
| NFPA 704 |
|
Cyclohexylamine price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.02885 | Cyclohexylamine for synthesis | 108-91-8 | 100ML | ₹5440 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02885 | Cyclohexylamine for synthesis | 108-91-8 | 1L | ₹5550 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02885 | Cyclohexylamine for synthesis | 108-91-8 | 2.5L | ₹5650.01 | 2022-06-14 | Buy |
| Sigma-Aldrich | 240648 | Cyclohexylamine ReagentPlus?, ≥99.9% | 108-91-8 | 5ML | ₹2890.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 240648 | Cyclohexylamine ReagentPlus?, ≥99.9% | 108-91-8 | 5ML | ₹2890.28 | 2022-06-14 | Buy |
Cyclohexylamine Chemical Properties,Uses,Production
Production Methods
Cyclohexylamine is produced by the reaction of ammonia and cyclohexanol at elevated temperature and pressure in the presence of a silica-alumina catalyst (SRI 1985). It is also prepared by a similar process of catalytic hydrogenation of aniline at elevated temperature and pressure. Fractionation of the product of this reaction yields CHA, aniline, and a high-boiling residue containing n-phenylcyclohexylamine and dicyclohexylamine (Carswell and Morrill 1937). In 1982, U.S. production was 4.54 metric tons and 739.3 metric tons were imported into the U.S. (SRI 1985).
General Description
Cyclohexylamine appears as a clear colorless to yellow liquid with an odor of ammonia. Flash point 90 °F. Irritates the eyes and respiratory system. Skin contact may cause burns. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.
Air & Water Reactions
Highly flammable. Sensitive to air and light. Soluble in water.
Reactivity Profile
Cyclohexylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
Cyclohexylamine is a severe irritant to theeyes, skin, and respiratory passage. Skincontact can produce burns and sensitization;contact of the pure liquid or its concentratedsolutions with the eyes may cause loss ofvision.
The acute oral and dermal toxicity ofcyclohexylamine was moderate in test sub jects. The toxic effects include nausea, vom iting, and degenerative changes in the brain,liver, and kidney. Inhalation of its vaporsat high concentrations may cause a narcoticeffect.
LD50 value, oral (rats): 156 mg/kg
LD50 value, skin (rabbits): 277 mg/klg
Cyclohexylamine may be mutagenic, thetest for which has so far given inconclusiveresults. Administration of this compoundin animals produced a reproductive effect,including embryotoxicity and a reductionin male fertility. Intraperitoneal injectionof the amine in rats caused a dose dependent increase in chromosomal breaks.Roberts and coworkers (1989) studied themetabolism and testicular toxicity of cyclohexylamine (a metabolite of cyclamate)in rats and mice. Chronic dietary administration of 400 mg/kg/day for 13 weeksshowed decrease in organ weigh, histological changes, and testicular atrophy in boththe Wistar and dark agouti DA rats, but to awidely varying extent, while mice exhibitedno evidence of testicular damage.
There is no evidence of carcinogenicityin animals or humans caused by cyclohexy lamine.
Fire Hazard
When heated to decomposition, Cyclohexylamine emits highly toxic fumes. Vapor may travel a considerable distance to source of ignition and flash back. Toxic oxides of nitrogen are produced during combustion. Nitric acid; reacts vigorously with oxiding materials. Stable, avoid physical damage, storage with oxidizing material.
Industrial uses
The primary use of cyclohexylamine is as a corrosion inhibitor in boiler water treatment and in oil field applications (HSDB 1989). It is also a chemical intermediate for rubber processing chemicals, dyes (acid blue 62, former use), cyclamate artificial sweeteners and herbicides and a processing agent for nylon fiber production (SRI 1985). Windholz et al (1983) reports its use in the manufacture of insecticides, plasticizers, emulsifying agents, dry-cleaning soaps, and acid gas absorbents.
Safety Profile
A poison by ingestion, skin contact, and intraperitoneal routes. Experimental teratogenic and reproductive effects. A severe human skin irritant. Can cause dermatitis and convulsions. Human mutation data reported. Questionable carcinogen. Flammable liquid. Dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.
Synthesis
Prepared by catalytic hydrogenation of aniline at elevated temp and pressures. Fractionation of crude reaction product yields cyclohexylamine, unchanged aniline, and high-boiling residue containing n-phenylcyclohexylamine (cyclohexylaniline) and dicyclohexylamine.
Potential Exposure
CHA is used in making dyes, chemi- cals, dry cleaning chemicals; insecticides, plasticizers, rub- ber chemicals; and as a chemical intermediate in the production of cyclamate sweeteners. Used in water treat- ment and as a boiler feedwater additive. It is also used in rubber production to retard degradation.
Carcinogenicity
According to the International Agency for Research of Cancer (IARC) working group, there is no evidence that cyclohexylamine is teratogenic or carcinogenic.
storage
Cyclohexylamine can be stored and shipped in iron tanks. Nonferrous metals, particularly copper-containing materials, are attacked and are therefore unsuitable. The amine discolors on contact with air and therefore must be kept under nitrogen.
Shipping
UN2357 Cyclohexylamine, Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.
Purification Methods
Dry the amine with CaCl2 or LiAlH4, then distil it from BaO, KOH or Na, under N2. Also purify it by conversion to the hydrochloride (which is crystallised several times from water), then liberation of the amine with alkali and fractional distillation under N2. The hydrochloride has m 205-207o (dioxane/EtOH). [Lycan et al. Org Synth Coll Vol II 319 1943, Beilstein 12 III 10, 12 IV 8.]
Incompatibilities
May form explosive mixture with air. Cyclohexylamine is a strong base: it reacts violently with acid. Contact with strong oxidizers may cause fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alco- hols, glycols, phenols, cresols, caprolactum solution; lead. Corrosive to copper alloys, zinc, or galvanized steel.
Waste Disposal
Incineration; incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions.
Cyclohexylamine Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ULTIMA CHEMICALS | +91 7208029458 | Mumbai, India | 95 | 58 | Inquiry |
| Sagar Speciality Chemicals Private Limited | +91-9619603699 +91-9619603699 | Maharashtra, India | 48 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| LANXESS India Pvt. Ltd. | +91-8356878763 +91-8356878763 | Maharashtra, India | 190 | 58 | Inquiry |
| Acuro Organics Limited | +91-8882777000 +91-8882777000 | New Delhi, India | 44 | 58 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Dr Prem's Molecules Pvt. Ltd. | +91 9825310038 | New Delhi, India | 547 | 50 | Inquiry |
| A. B. Enterprises | +91-8048077585 | Mumbai, India | 1396 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ULTIMA CHEMICALS | 58 |
| Sagar Speciality Chemicals Private Limited | 58 |
| JSK Chemicals | 58 |
| KARPSCHEM LABORATORIES | 58 |
| LANXESS India Pvt. Ltd. | 58 |
| Acuro Organics Limited | 58 |
| Scientific OEM | 38 |
| ALPHA CHEMIKA | 43 |
| Dr Prem's Molecules Pvt. Ltd. | 50 |
| A. B. Enterprises | 58 |
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