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Bromfenac Sodium

Bromfenac Sodium Structure
CAS No.
120638-55-3
Chemical Name:
Bromfenac Sodium
Synonyms
Duract;Unii-8ecv571Y37;Bromfenac sodiu;Bromfenac sodium;Bromfenac ophthalmic;acetate hydrate(2:2:3);Bromfenac sodium hydrate;BroMfenac sodiuM 1.5H2O;Sodium bromfenate hydrate;Bromfenac ophthalmic solution
CBNumber:
CB82130312
Molecular Formula:
C15H11BrNNaO3
Molecular Weight:
356.15
MOL File:
120638-55-3.mol
Modify Date:
2024/7/2 8:55:18

Bromfenac Sodium Properties

Melting point 268-270°C (dec.)
storage temp. Refrigerator
solubility DMSO: ≥ 100 mg/mL (260.98 mM); Water: ≥ 100 mg/mL (260.98 mM)
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Signal word  Danger
Hazard statements  H372-H300
Precautionary statements  P260-P264-P270-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501

Bromfenac Sodium Chemical Properties,Uses,Production

Description

Duract was launched in the US as a potent, orally-active, long lasting peripheral analgesic with antiinflammatory properties. It is structurally similar to ketoprofen and diclofenac and can be prepared in three steps from 2-amino-4’-bromophenone using Gassman’s oxindole synthesis. Duract’s biological effects are a result of its ability to reduce prostaglandin production through inhibition of cyclooxygenase. As a 4-bromo derivative of Amfenac, this modification increased the duration of analgesic activity and antiinflammatory potency. It was also free of any CNS, cardiovascular or autonomic effects. In comparison, 5 mg of Duract was equipotent to 650 mg of ASA and 25 mg was slightly more potent than 400 mg of Ibuprofen.

Chemical Properties

Yellow Solid

Uses

Bromfenac is a non-steroidal anti-inflammatory agent.

Definition

ChEBI: The sesquihydrate of the sodium salt of bromfenac. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction.

Bromfenac Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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bromfenac sodium salt sesquihydrate Benzeneacetic acid,2-amino-3-(4-bromobenzoyl)-,sodium salt,hydrate(2:2:3) Bromfenac sodiu Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate Benzeneacetic acid, 2-amino-3-(4-bromobenzoyl)-, monosodium salt, hydrate (2:3) Bromfenac ophthalmic Bromfenac ophthalmic solution Duract Sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate Unii-8ecv571Y37 Bromfenac monosodium salt sesquihydrate Bromfenac Sodium Sesquihydrate Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate hydrate Bromfenac sodium hydrate 2-AMino-3-(4-broMobenzoyl)benzeneacetic Acid SodiuM Salt Hydrate BroMfenac sodiuM 1.5H2O Sodium 2-(2-amino-3-(4-bromobenzoyl)-phenyl)acetate trihydrate acetate hydrate(2:2:3) Sodium 2-(2-amino-3-(4-bromobenzoyl) Sodium 2-(2-amino-3-(4-bromobenzoyl)phenyl)acetate hydrate(2:2:3) Bromfenac Sodium Sesquihydrate USP/EP/BP Sodium bromfenate hydrate Bromfenac sodium Bromfenac sodium|||Bromfenac monosodium salt sesquihydrate 120638-55-3 C15H12BrNNaO315H2O 2C15H11BrNNaO33H2O C15H17BrNNaO6 C30H28Br2N2Na2O9 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals API